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A real time look at interactions between RNA and proteins

s a cell-penetrating peptide called transportan 10 to first get the PNA through the cell membrane. Once in the cell, the PNA binds to a specific target messenger RNA (mRNA). There is also a compound on the molecule that can be activated by light and will cross-link the PNA to whatever protein is nearby. The researchers isolated an array of proteins from the complex of the PNA, the targeted mRNAs, and associated RNA-binding proteins. The cells are then broken apart and the proteins that interact with the mRNA are identified with a mass spectrometer.

With their system, the researchers are trying to identify RNA-binding proteins that bind RNAs of interest–such as those involved in the targeting, degradation, and translation of RNAs into proteins. Once identified, the Eberwine team uses another technology they developed to find the other RNA cargos that bind to that RNA-binding protein. These are other RNAs that likely co-regulate RNAs associated with disease.

The research was supported by grants from the National Institutes of Health, the Swedish Science Foundation, and the European Community. Study coauthors are Jennifer Zielinski, Tiina Peritz, Jeanine Jochems, Theresa Kannanayakal, and Kevin Miyashiro, from Penn, and Kalle Kilk, Emilia Eiriksdóttir, and Ûlo Langel from Stockholm University, Sweden. This release can be found at http://www.uphs.upenn.edu/news/


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Source:University of Pennsylvania School of Medicine


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