Navigation Links
A real time look at interactions between RNA and proteins

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe–in real-time–the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions. Researchers at the University of Pennsylvania School of Medicine who developed the new technology see this advance as one of the next logical steps in genomics research. Senior author James Eberwine, PhD, Professor of Pharmacology at Penn, and colleagues published their research this week in the Proceedings of the National Academy of Sciences.

"Now we have a workable system to understand all aspects of RNA metabolism in a cell," say Eberwine. "For the first time, we can study how manipulation of cellular physiology, such as administering a drug, changes RNA-binding protein and RNA interactions. This technology allows us to see that in real time in real cells."

RNA is the genetic material that programs cells to make proteins from DNA's blueprint and specifies which proteins should be made. There are many types of RNA in the cells of mammals, such as transfer RNA, ribosomal RNA, and messenger RNA–each with a specific purpose in making and manipulating proteins.

The workhorses of the cell, RNA-binding proteins regulate every aspect of RNA function. Indeed, RNA is transported from one site to another inside the cell by RNA-binding proteins; RNA is translated into protein with the help of RNA-binding proteins, and RNA-binding proteins degrade used RNA. "They're really the master regulators of expression in the cell," says Eberwine.

Using whole neurons from rodents, the researchers were able to identify RNA interactions in live cells. In collaboration with Ûlo Langel from Stockholm University, the Penn investigators devised a many-talented molecule that does not get broken down by enzymes once inside a live cell. One end of the molecule, called a peptide nucleic acid (PNA), ha
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2

Related biology news :

1. Virus-host interactions at sea effect global photosynthesis
2. Computational verification of protein-protein interactions by orthologous co-expression
3. Complex gene interactions account for autism risk
4. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
5. Biologists develop genome-wide map of miRNA-mRNA interactions
6. APS lecturer shows rare video of teacher-student immune cell interactions in live animal
7. Small molecule interactions were central to the origin of life
8. Variation in womens X chromosomes may explain differences among individuals, between sexes
9. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
10. Study reveals dramatic difference between breast cancers in US and Africa
11. Molecular fossils uncover link between viruses and the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: real time look interactions between RNA and proteins

(Date:9/30/2014)... new research, involving mice and published in the October ... Biology , suggests that just because you can ... a team of Italian scientists have found that using ... the immune system. This damage may result in autoimmune ... inflammatory bowel disease and rheumatoid arthritis in adulthood. , ...
(Date:9/30/2014)... trouble getting pregnanteven with IVF? Here,s some hope: A ... The FASEB Journal , explains how ... known as PAWP, which induced embryo development in human ... embryo development by the sperm cell during fertilization. , ... a major paradigm shift in our understanding of human ...
(Date:9/30/2014)... perilous threats in today,s ocean. From overfishing and ... coral ecosystems are disappearing at unprecedented rates around ... corals surrounding the island of Moorea in French ... environment: coral guard-crabs. New research from the National ... Seabird McKeon and the museum,s predoctoral fellow Jenna ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... selected 20 project proposals across Africa to receive support ... cycle and to improve water-monitoring resources. TIGER II ... precursor TIGER I, which sought to help African countries ... gap using Earth-observation (EO) technology. ,Under TIGER ...
... University research team has demonstrated that all sweeteners are not ... to high-fructose corn syrup gained significantly more weight than those ... intake was the same. In addition to ... high-fructose corn syrup also led to abnormal increases in body ...
... cells responsible for immune surveillance in the brain, and ... damage and infection. An international team under the leadership ... that these cells may actually make a significant contribution ... About 1.2 million people are thought to suffer from ...
Cached Biology News:ESA's TIGER II to support 20 water projects in Africa 2ESA's TIGER II to support 20 water projects in Africa 3Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain 2Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain 3Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain 4Dangerous custodians 2
(Date:9/30/2014)... the last decade, the laboratory filtration market is experiencing ... acceptance of new filtration technologies in end users market. ... catalyzing the growth of laboratory filtration market. , The ... a strong CAGR during the forecast period of 2014-2019 ... 2019. The market is mainly driven by the increasing ...
(Date:9/30/2014)... Sept. 30, 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: ... it has received a Canadian Patent for Inhibition ... This patent includes claims using thymosin beta 4, ... peptides for these purposes.  The patent will expire ... Inc. ( www.regenerx.com ) RegeneRx ...
(Date:9/30/2014)... 30, 2014 Genedata, a ... drug discovery and related life science research, ... chosen Genedata Selector as its host-pathogen data ... FUNGITECT is a European consortium dedicated to ... via individualized anti-fungal drug therapies. Genedata Selector ...
(Date:9/30/2014)... 30, 2014 BioHealth Innovation, Inc. ... biohealth innovations and increasing access to early-stage funding in ... venture capitalist, Tania Fernandez , Ph.D., has joined ... will be a member of the management team for ... to $50 million in seed and early-stage equity investments ...
Breaking Biology Technology:Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2
... For Women in Science program is welcoming the 15 International Fellows ... , On Wednesday, March 28, from 4 pm to ... the Pasteur Institute in Paris. Following these presentations, a cocktail ... be met individually , , On ...
... physics of massive particles has intrigued physicists for more than ... exhibit wave-like behaviour in conflict with our everyday ideas ... of scientists now succeeded in shooting a movie which shows ... molecules which is so large (up to 0.1 mm) that ...
... March 22, 2012 /PRNewswire-iReach/ -- FirstMark, the ... announce that the company will be exhibiting at the ... College of Cardiology (ACC) in Chicago, March 24-27, Booth ... PREvent is the first and only multiple biomarker blood ...
Cached Biology Technology:The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 2The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 3The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 4Single molecules in a quantum movie 2FirstMark Exhibiting at the American College of Cardiology 61st Annual Scientific Sessions & Expo 2
Request Info...
with GlutaMAXIL-glutamine...
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
Biology Products: