Navigation Links
A puzzle piece found in unraveling the wiring of the brain

The complexity of the brain and, more specifically, how nerve cells form billions of contacts when there are fewer than 30,000 human genes is still a scientific mystery.

A team headed by Drs. Robin Hiesinger and Hugo J. Bellen at Baylor College of Medicine in Houston have unraveled a piece of that puzzle by finding a gene that plays a key role in brain wiring. A report on their work appears today in the journal Neuron.

"We were surprised to find an exocyst mutant having such specific defects," said Bellen, professor of molecular and human genetics at BCM. "The cell biological basis of brain wiring is largely unknown. We are happy to have a new handle on an old problem."

Using sophisticated genetics applied to the brain of the fruit fly, Drs. Sunil Mehta and Hiesinger found a gene named sec15 that is required for nerve cells to make appropriate choices of targets on which to act.

The Sec15 protein is part of a protein complex (the exocyst) which is known to be required for secretion (or exocytosis) of vesicular compartments in yeast. Vesicular compartments are small organelles that transport proteins from one site to another in the cell.

Neurons in the fly brain that lack sec15 not only display aberrant wiring patterns, but also show misplacement of proteins required for correct nerve cell contact choices.

Most of these cell contact proteins were previously known to display highly dynamic expression patterns in both time and space, but how they are put at the right time and at the right place remains to be shown. This study answers part of that question.

Others who participated in this work include Dr. Mike Crair of BCM, Drs. R. Grace Zhai, Karen L. Schulze, Patrik Verstreken, Yu Cao and Yi Zhou from the Howard Hughes Medical Institute at BCM and Drs. Slobodan Beronja and Ulrich Tepass from the University of Toronto.


'"/>

Source:Baylor College of Medicine


Page: 1

Related biology news :

1. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
2. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
3. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
4. Unraveling a stomach cancer puzzle
5. Sinkers provide missing piece in deep-sea puzzle
6. Unweaving amyloid fibers to solve prion puzzles
7. Scientists crack 40-year-old DNA puzzle and point to hot soup at the origin of life
8. Computer-chemistry yields new insight into a puzzle of cell division
9. Bees solve complex colour puzzles
10. UW scientists unravel critical genetic puzzle for flu virus replication
11. Major link in brain-obesity puzzle found
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... Ind. , Feb. 7, 2017 Zimmer ... leader in musculoskeletal healthcare, will present at the LEERINK ... New York Palace Hotel on Wednesday, February 15, 2017 ... live webcast of the presentation can be accessed at ... replay following the conference via Zimmer Biomet,s Investor Relations ...
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
(Date:2/3/2017)... A new independent identity strategy consultancy firm ... . Designed to fill a critical niche in technical ... partners Mark Crego and Janice Kephart ... identity expertise that span federal governments, the 9/11 Commission, ... combined expertise has a common theme born from a ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017  PrimeVax Immuno-Oncology, Inc. announced ... presenting at the Annual Biocom Global Life Science Partnering ... at 11:15 AM, at the Torrey Pines Lodge, in ... the organizers at Biocom who have chosen our company, ... of biotechnology companies, investors, and clinical researchers," said Mr. ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... provider of women’s health, primary care, and specialty education, announced today it ... Education (ACCME). ACCME’s Accreditation with Commendation is a six-year accreditation and is ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... and scientists from around the world, is pleased to announce the 2nd annual ... 23, 2017. This premier, online-only conference focused on the development and advancements in ...
(Date:2/22/2017)... 22, 2017 Dublin ... "Global Biological Crop Protection (Bio-Pesticide) Market-By Type, By Application, By End ... to their offering. ... Global Biological Crop Protection Market is forecasted to grow at ... growth in biopesticide or biological crop protection market is driven by ...
Breaking Biology Technology: