( ell division. If these tangles which a...)A protein complex that untangles DNA

ell division. If these tangles, which are a natural consequence of the DNA copying process, are left unresolved the chromosomes cannot be separated and sent to the two nascent daughter cells. Like in the repair process, the Smc5/6 complex appears to resolve these intertwines by direct interaction with the DNA molecules, but this process is differently regulated as compared to the function in repair.

"Evidence points to that the Smc5/6 complex work in two different pathways, one needed for repair and the other for untangling. We now aim to study how this works on a molecular level. This will bring us one step closer to the general goal ?a summary of the many mechanisms that collaborate to maintain our genetic stability", says Camilla Sjögren.

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Source:Karolinska Institutet


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