Navigation Links
A new window into structural plasticity in the adult visual cortex

Neuroscientists have known for decades that the adult brain can reorganize neural pathways in response to new experiences, for example, by changing the firing pattern and responses of neurons. But it has remained an open question whether structural changes accompany this functional plasticity. In a new study published in the open-access journal PLoS Biology, Wei-Chung Allen Lee and colleagues report the continuous monitoring of neurons in the mouse adult visual cortex over the course of a few months, revealing that the adult brain can indeed rewire its circuits under normal conditions.

The authors focused on the surface layers of the neocortex. To allow direct observation of the area, they implanted a glass window over the two areas of the visual cortex in four- to six-week-old mice. These mice express fluorescent protein in neocortical neurons, allowing Lee et al. to track the location and morphology of these neurons using two-photon microscopy. Time-lapse images of six pyramidal neurons and eight nonpyramidal neurons in 13 mice were taken over the course of four to ten weeks. The length of dendritic branch tips was measured over time to evaluate physical changes in the neurons.

Many studies have focused on pyramidal neurons--excitatory neurons that promote neuron firing--but few have focused on the possible structural dynamics of a range of different neuron types. Surprisingly, the only neurons they saw growing were the so-called interneurons, which contain the neurotransmitter GABA and inhibit the activity of cortical neurons. The pyramidal neurons showed no structural changes in individual branch tips, but the inhibitory neurons showed dynamic changes, with one branch tip undergoing dramatic remodeling. "Within as little as two weeks," the authors note, "this branch tip more than doubled its length and exited the imaging volume." One nonpyramidal neuron even showed a few new branch tip additions.

The authors conclude that the cortic
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Fruit fly studies open new window on cancer research
2. Membrane research opens window to benefits for plants, humans
3. Cord blood cells may widen treatment window for stroke
4. Creating a window on oceans in motion
5. Study offers window into human behavior, brain disease
6. Opening windows may be the best way of preventing transmission of airborne infection
7. Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
8. Meditation associated with structural changes in brain
9. New technology used to construct the first map of structural variation in the human genome
10. Researchers image molecular motor structural changes
11. Scripps research study reveals structural dynamics of single prion molecules
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new window into structural plasticity the adult visual cortex

(Date:8/28/2014)... action is needed to ensure safeguards are in place ... PLOS ONE , researchers from Monash University, Stellenbosch ... combining results from different studies - to look at ... to determine whether they actually protect biodiversity. , ... an area from human exploitation made common sense, however, ...
(Date:8/27/2014)... Most of North America,s megafauna mastodons, short-faced bears, ... horses disappeared close to 13,000 years ago at ... this massive extinction has long been debated by scientists ... , A group of scientists, including UC Santa Barbara,s ... Science, posited that a comet collision with Earth played ...
(Date:8/27/2014)... a group of fish began exploring land and evolved into ... how these ancient fish used their fishy bodies and fins ... play remain scientific mysteries. , Researchers at McGill University ... living fish, called Polypterus , to help show what ... of the water. Polypterus is an African fish ...
Breaking Biology News(10 mins):Protected areas proven to protect biodiversity 2Nanodiamonds are forever 2Nanodiamonds are forever 3Walking fish reveal how our ancestors evolved onto land 2
... of amphibians drastically decreases in forest areas that are ... researcher, however, has found that some animals may not ... may be moving away (possibly to return later) or ... both the timber industry and the survival of amphibians. ...
... changes to a gene that do not alter ... bipolar disorder. This is the first epigenome-wide investigation ... be a significant step on the journey to ... senior scientist in the Krembil Family Epigenetic Laboratory ...
... March 10 BIO-key International,Inc. (OTC Bulletin Board: BKYI) today ... results on Monday, March 17, 2008,after the market close. In ... will be broadcast live over the Internet,on Tuesday, March 18, ... BIO-key International, Inc. Fourth Quarter and Full Year 2007 ...
Cached Biology News:Amphibians respond behaviorally to impact of clear cutting 2Epigenetic changes discovered in major psychosis 2BIO-key(R) Announces Fourth Quarter and Full Year 2007 Earnings Release and Conference Call Schedule 2
(Date:8/27/2014)... DENVER , Aug. 27, 2014   MSC ... and patient safety, today announced the appointment of ... With 28 years of experience preparing companies ... in 2013 as Executive Vice President of Corporate Development ... healthcare performance improvement business , as well as corporate ...
(Date:8/27/2014)... , Aug. 27, 2014 ... the "Global Lactic Acid  (Biodegradable Polymer, Food ... Trends & Forecasts to 2019" report to ... simplest hydroxyl-carboxylic acid with an asymmetrical carbon atom. ... the biodegradable polymer, food and beverage, personal care ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, the ... today announced the hiring of veteran equity analyst Charles ... analyst. Mr. Butler will focus on the biotech/biopharma sector. ... a wealth of experience and a broad network of ... Senior Managing Director and Head of Equities at Guggenheim ...
(Date:8/27/2014)... , Aug. 27, 2014 Research and ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014 is ... of the global isotope ratio mass spectrometer industry. ... industry including definitions, classifications, applications and industry chain structure. ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... France, April 23 , - ... Essilor International, the world leader in ophthalmic optics, today,announced ... 31, 2009, representing a reported 10.3% increase on the first ... the period. , Despite contracting demand ...
... RICHMOND, Calif., April 22 Sangamo BioSciences, Inc. (Nasdaq: ... will release its first quarter 2009 financial results on ... press release will be followed by a conference call ... the public via telephone and webcast. During the conference ...
... to Discuss Results to Be Held at 9:00 A.M. - ... VPHM ) first quarter financial results for 2009 are ... the open of the U.S. financial markets.The company will host ... Eastern Time on the same day. During the conference ...
Cached Biology Technology:Essilor : 2009 First Quarter Report 2Essilor : 2009 First Quarter Report 3Essilor : 2009 First Quarter Report 4Sangamo BioSciences Announces First Quarter 2009 Conference Call and Webcast 2Sangamo BioSciences Announces First Quarter 2009 Conference Call and Webcast 3ViroPharma to Release 2009 First Quarter Financial Results on April 29, 2009 2
... Product Goat polyclonal to Cholesterol ... Reactivity / Specificity Cross-reacts with ... Background Information Cholesterol oxidases exist ... oxidases and are implicated in bacterial pathogenesis. ...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Goat polyclonal to XAGE1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGFGFRRQGEDNT, corresponding to C terminal amino acids 149-160 of Human XAGE1 Entrez Gene ID: 9...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Biology Products: