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A new window into structural plasticity in the adult visual cortex

Neuroscientists have known for decades that the adult brain can reorganize neural pathways in response to new experiences, for example, by changing the firing pattern and responses of neurons. But it has remained an open question whether structural changes accompany this functional plasticity. In a new study published in the open-access journal PLoS Biology, Wei-Chung Allen Lee and colleagues report the continuous monitoring of neurons in the mouse adult visual cortex over the course of a few months, revealing that the adult brain can indeed rewire its circuits under normal conditions.

The authors focused on the surface layers of the neocortex. To allow direct observation of the area, they implanted a glass window over the two areas of the visual cortex in four- to six-week-old mice. These mice express fluorescent protein in neocortical neurons, allowing Lee et al. to track the location and morphology of these neurons using two-photon microscopy. Time-lapse images of six pyramidal neurons and eight nonpyramidal neurons in 13 mice were taken over the course of four to ten weeks. The length of dendritic branch tips was measured over time to evaluate physical changes in the neurons.

Many studies have focused on pyramidal neurons--excitatory neurons that promote neuron firing--but few have focused on the possible structural dynamics of a range of different neuron types. Surprisingly, the only neurons they saw growing were the so-called interneurons, which contain the neurotransmitter GABA and inhibit the activity of cortical neurons. The pyramidal neurons showed no structural changes in individual branch tips, but the inhibitory neurons showed dynamic changes, with one branch tip undergoing dramatic remodeling. "Within as little as two weeks," the authors note, "this branch tip more than doubled its length and exited the imaging volume." One nonpyramidal neuron even showed a few new branch tip additions.

The authors conclude that the cortic
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Source:Public Library of Science


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