Navigation Links
A new way to share models of biological systems

Today sees the launch of BioModels, the world's first database of annotated biological models. BioModels is the result of a collaboration led by the European Bioinformatics Institute (UK) and the SBML Team, an international group that develops open-source standards to describe biological systems. Other contributors include the Keck Graduate Institute (USA), the Systems Biology Institute (Japan) and Stellenbosch University (South Africa).

Even the simplest living organisms perform a mind-boggling array of different processes, which are interconnected in complex ways to ensure that the organism responds appropriately to its environment. One of the best ways of ensuring that we really understand how these processes fit together is to build computer models of them. If a computer model behaves differently than the real organism, we know that we've neglected an important component of the system. Quantitative models can also reveal previously unappreciated properties of complex systems, paving the way towards new drug treatments. This approach, known as 'computational systems biology,' is becoming increasingly popular now that scientists are accumulating detailed parts lists for many organisms, thanks to genome sequencing projects and other efforts to comprehensively document the components of living entities.

"Until now, computer modellers had no defined way of exchanging descriptions of biological systems, and there was no accepted place to deposit and share new models when they were developed," explains the EBI's Nicolas Le Novère. "The BioModels database aims to address these issues."

The first step was to develop a standard way of describing such models. The Systems Biology Markup Language (SBML), an open-source computer language developed by the SBML Team, is now widely accepted and is supported by over 75 different software systems worldwide. This allows computational systems biologists to write models using the tool of their choice, and then to share them so that others can build on their work.

Michael Hucka of the California Institute of Technology continues: "The next logical step was to build a community resource that would allow anyone to submit, download and reuse the models. That's the purpose of the BioModels database. BioModels provides access to published, peer-reviewed, quantitative models of biochemical and cell-biological systems."

Some of these systems are very simple, containing just a few processes or reactions; others contain hundreds. The models are checked to verify that they correspond to the reference publication. Human curators annotate and cross-link components of the models to other relevant data resources. This allows users to identify precisely the components of models, and helps them to retrieve appropriate models, which they can then visualize and build upon using any SBML-compatible software.

"Ultimately," says Le Novère, "we hope that publishers will encourage any author who plans to publish a new model to submit it to the BioModels database; this will ensure that all the models in the public domain are freely available for everyone to make the most of them."

The BioModels database is freely available at www.ebi.ac.uk/biomodels.


'"/>

Source:European Molecular Biology Laboratory


Related biology news :

1. Man and mouse share genome structures
2. Plants, animals share molecular growth mechanisms
3. Ancient olfaction protein is shared by many bugs, offering new pest control target
4. A new study examines how shared pathogens affect host populations
5. The lopsided brain: Attention bias is shared by humans and birds
6. Insects and mammals share common fat-building pathway, study suggests
7. Evolution mystery: Spider venom and bacteria share same toxin
8. More evidence mammals, fruit flies share make-up on function of biological clocks
9. Malaria, potato famine pathogen share surprising trait
10. Ocean seep mollusks may share evolutionary history with other deep-sea creatures
11. Bird flu -- Call for antiviral drugs to be shared
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/4/2016)... Feb. 4, 2016 The field of ... of the most popular hubs of the biotechnology ... other huge studies of human microbiota, have garnered ... years, the microbiome space has literally exploded in ... This report focuses on biomedical aspects of ...
(Date:2/3/2016)... 3, 2016 Vigilant Solutions announces today that ... Missouri solved two recent hit-and-run ... data from Vigilant Solutions. Brian Wenberg ... the victim was walking out of a convenience store and witnessed an elderly ... his vehicle, striking his vehicle and leaving the scene.  ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of the bioinformatic market by reviewing the recent ... enabled tools that drive the field forward. Includes ... to: Identify the challenges and opportunities that ... providers and software solution developers, as well as ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , ... February 10, 2016 ... ... today announced that it has joined the Human Vaccines Project, a public-private ... diseases and cancer. , The Human Vaccines Project brings together leading ...
(Date:2/10/2016)... 2016  Allergan plc (NYSE: AGN ) a ... Saunders , Allergan,s CEO and President, will be featured ... at the RBC Capital Markets Healthcare Conference on Tuesday, ... New York Palace Hotel in New York, ... and can be accessed on Allergan,s Investor Relations web ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... states, announced today the promotion of two long-standing principal investigators (PI) to the ... Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research PI ...
(Date:2/10/2016)... ... February 10, 2016 , ... LATHAM, NEW YORK... Marktech Optoelectronics ... Photonics West conference in San Francisco’s Moscone Center from February 16-18, 2016, and ... , These latest InGaAs PIN diode standard packages feature a TO-46 metal can ...
Breaking Biology Technology: