Navigation Links
A new tool against brain disease

ssion, the higher the patient's viral load and the lower the count of helper T cells, said Walker.

When they compared PD-1 activation in blood samples from four patients before and after antiviral therapy, they found that PD-1 expression dropped when treatment began. "It became very clear from this analysis that the virus was actually driving these high levels of PD-1 expression, and that you could actually change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction.

Walker said one of the team's key findings emerged from their test tube studies showing that blocking the PD-1 pathway could restore the function of exhausted killer T cells. "We wanted to determine whether these T cells had been irreparably damaged or misprogrammed," he said. "And we found that they are capable of functioning; they've just been turned off."

Similarly, the researchers also found that blocking PD-1 restored helper T cell function. "This was the most striking finding, because the majority of patients we have studied had no detectable levels of these HIV-specific cells; but as soon as we blocked the PD-1 pathway, they had a ton of them," said Walker.

The researchers' discoveries could lead to immediate clinical application, although Walker cautioned against over-optimism. "Obviously, the big question is whether you could manipulate this pathway in HIV-infected people to turn these T cells back on and better control the virus," he said. "And drugs to block this pathway have already been developed for cancer, so that question should be able to be addressed in the very near future.

"However, one has to proceed with real caution, because if you turn back on an immune regulatory switch that the body has decided to turn off, you could trigger serious immunological problems such as
'"/>

Source:leesiegel@ucomm.utah.edu


Page: 1 2 3 4

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Female sex hormones play a vital role in defense against sexually transmitted diseases
4. In the sea slugs defense against lobsters, confusion is key
5. Antibodies from plants protect against anthrax
6. Molecular models advance the fight against malaria
7. Sickle cell and protection against malaria
8. Live vaccines more effective against horse herpes virus
9. Turning viruses into allies against cancer
10. Friendly bacteria in humans may protect against HIV
11. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new tool against brain disease

(Date:8/20/2014)... Using population-based screening outcomes of approximately 3 million ... four researchers at the University of Massachusetts Medical School, ... (SCID) can be successfully implemented across public health newborn ... in the Aug. 20 issue of the Journal ... showed the rate of SCID in newborns is higher ...
(Date:8/20/2014)... of Health has awarded the Oklahoma Medical Research Foundation ... on anthrax and the bacteria,s effects on humans. ... and his colleagues have studied the human immune response ... for Human Immunology. The original funding came soon after ... heels of the terrorist attacks of Sept. 11, 2001. ...
(Date:8/20/2014)... athletes who have suffered concussions ready to return to ... that high school athletes who head back on the ... significant regression in their abilities to simultaneously walk and ... in changes in their balance and/or altered walking speed, ... the 12 had returned to activity in less than ...
Breaking Biology News(10 mins):Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3$14.5 million grant awarded to continue anthrax studies 2Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... Previously unknown molecules and regulatory pathways in human ... effort of the Medizinische Poliklinik, Munich, the University ... Research Center, sanofi-aventis, and Genomatix Software GmbH. , ... the National Academy of Sciences of the United ...
... of the biggest problems in fighting breast cancer is ... , Researchers at the University of Michigan hope to ... for the presence of metabolites associated with breast cancer. ... award, which funds promising, high-risk, high reward research proposals ...
... from two universities in Italy and Virginia Tech in ... protein that is responsible for the production xanthurenic acid ... plays a key role in the sexual reproduction of ... Interfering with the formation of XA could be an ...
Cached Biology News:Researchers win money to develop breath test to detect breast cancer 2Oxidation defense in mosquitoes benefits malaria parasite 2
(Date:8/21/2014)... (PRWEB) August 21, 2014 The College ... first private college in the Mid-Hudson Region to be ... now begin accepting applications from qualified “high-technology” businesses that ... are very pleased to have been selected for the ... Cuomo’s transformative initiative to stimulate economic development in New ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary ... by the Jeffrey Epstein VI Foundation , have shown ... identified for elimination. These aggressive cells are the driver mutations ... topological map of what to look for when examining tumors, ... tumor cells can be extracted from biopsy, it,s very difficult ...
(Date:8/21/2014)... -- China Cord Blood Corporation (NYSE: CO ) ... results for the first quarter of fiscal year 2015 ... the US.  The Company will host ... August 29, 2014 to discuss its financial performance and ... followed by a question and answer session.  Interested parties ...
(Date:8/21/2014)... Chester, NJ (PRWEB) August 21, 2014 ... of personal selling optimization technology and services for ... publication of “Grading Pharma’s Use of New Commercial ... of Measurement & Analytics. , The article examines ... marketing yield that are being tested in the ...
Breaking Biology Technology:The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2
... cells are not pampered pushovers. O,Reilly et al. report ... molding their environment to control their division and differentiation., ... cradle them in a structure called the niche. The ... their behavior, determining whether they reproduce and specialize. The ...
... from Chinese Health Authorities to Launch Final ... Clinical Trial for ... Inc.,today announced the appointment of Dr. Geert Cauwenbergh as Chief ... Cauwenbergh has been assisting RHEI Pharmaceuticals since August 1, 2008,in ...
... 25 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ), ... and marketing biopharmaceutical products,primarily in China, announces that ... Morgan Stanley Global Healthcare Unplugged Conference in New,York ... A copy of the latest investor presentation ...
Cached Biology Technology:RHEI Pharmaceuticals Appoints Dr. Geert Cauwenbergh as Chief Executive Officer 2RHEI Pharmaceuticals Appoints Dr. Geert Cauwenbergh as Chief Executive Officer 3RHEI Pharmaceuticals Appoints Dr. Geert Cauwenbergh as Chief Executive Officer 4
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
This antibody detects ubiquitinated proteins on SDS-PAGE immunoblots. It does not detect free ubiquitin....
... and BR4i refrigerated multifunction centrifuges are equally capable ... a low sound level with a large range ... AUTO-LOCK rotor exchange system without tools ensures that ... seconds. Instant rotor exchange (5 sec.) ...
... Jouan B4i ventilated and BR4i refrigerated multifunction centrifuges ... speed operation at a low sound level with ... for biocontainment. Their AUTO-LOCK rotor exchange system without ... for use within seconds. Instant rotor ...
Biology Products: