Navigation Links
A new tool against brain disease

American and South African scientists working at the epicenter of the AIDS epidemic in South Africa have discovered how the human immunodeficiency virus (HIV) "exhausts" killer T cells that would otherwise attack the virus. The researchers found that HIV can simply "turn off" fully functional T cells by flipping a molecular switch on the cells. In test tube studies, however, the scientists showed that they could reinvigorate the killer T cells by blocking that inhibitory switch, which is called programmed death-1 (PD-1).

The study's senior author, Bruce Walker, a Howard Hughes Medical Institute researcher at Massachusetts General Hospital, said that clinical testing of drugs that block the PD-1 switch could begin very soon, since such drugs exist already. However, he cautioned that these kinds of drugs could cause serious side effects, including autoimmune reactions that trigger the immune system to attack the body. Walker added that the researchers' findings will also likely have application in understanding other chronic viral diseases.

The findings by Walker and his colleagues were published in an advance online publication on August 20, 2006, by the journal Nature. Walker is also at the Partners AIDS Research Center and Harvard Medical School. Other co-authors were from the University of KwaZulu Natal in South Africa, Oxford University, Dana-Farber Cancer Institute of Harvard Medical School, Emory University School of Medicine, and The Wistar Institute.

"It's long been known that people with HIV infection have a lot of HIV-specific immune cells that one would think would be actively combating the virus," said Walker. "But a major puzzle has been that even in late-stage illness, when one can still measure great numbers of these immune cells, they don't seem to be controlling the virus at all."

An important clue to why killer T cells stop functioning after infection came from ear
'"/>

Source:leesiegel@ucomm.utah.edu


Page: 1 2 3 4

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Female sex hormones play a vital role in defense against sexually transmitted diseases
4. In the sea slugs defense against lobsters, confusion is key
5. Antibodies from plants protect against anthrax
6. Molecular models advance the fight against malaria
7. Sickle cell and protection against malaria
8. Live vaccines more effective against horse herpes virus
9. Turning viruses into allies against cancer
10. Friendly bacteria in humans may protect against HIV
11. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new tool against brain disease

(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor technology, ... such as Intel, Jabra, Atlas, and Scosche to develop ... products will be showcased at CES 2015, taking place ... "Our partners choose PerformTek biometrics, because ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation is fundamentally ... evident than at international borders. Over the past decade, ... veteran travelers to self process through border control via ... increasing number of airports, seaports, and land borders across ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... outbreaks, wildfire, and forest dieback, may adversely affect people ... The U.S. Geological Survey led a new ... "ecological thresholds" in North America. The report, which was ... authored by a team of federal and academic climate ...
... expert David S. Rose will present a lecture at ... You Think You Know...Is Wrong: How New Technologies and ... As part of the Heath Lecture Series at ... will discuss the latest technologies and concepts that are ...
... YORK, January 16, 2009 - Researchers at the University of ... adult beta cells have the ability to replicate with the ... was led by Andrew F. Stewart, M.D., a Professor of ... at the University of Pittsburgh School of Medicine. The ...
Cached Biology News:David Rose to present Howe School lecture on new technologies and business models, Jan. 29 2JDRF-funded researchers discover proteins regulating human beta cell replication 2
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... Medical Systems (NYSE: VAR ), world leader in ... to sustainability with inclusion on a prestigious list of the ... equipment company among the Corporate Knights Global 100 Most Sustainable ... Davos, Switzerland . "We ...
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... announced that it has entered into agreement with ... generated by 100 percent,renewable energy resources, through IPL,s ... of fossil-fueled power generation, this,program will better enable ... BST becomes the third-largest customer to participate in ...
... objective of the,Alliance is to improve patient care ... marketplace. To celebrate the Alliance, a symposium ... with noted speakers from industry, government,entrepreneurs, venture capitalists ... Gesellschaft. The alliance will take advantage of ...
... in Pioneering Field, BETHESDA, Md., Sept. 10 ... of an ownership interest in,ClinResearch GmbH, a global ... adaptive, clinical trials. Headquartered in Cologne, Germany,with more ... 80,adaptive programs over the past seven years. ClinResearch,s ...
Cached Biology Technology:BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 2BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 3BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 4'Alliance for Medical Devices, Instrumentation and Diagnostics' formed between Fraunhofer Center for Manufacturing Innovation and Boston University 2United BioSource Acquires Interest in Leading Adaptive Design Technology Service Provider 2
No description available in Ensembl Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: