Navigation Links
A new target for painkillers

Intosh co-authored the study with two colleagues in the University of Utah Center for Neuropeptide Pharmacology ?Baldomero "Toto" Olivera, a distinguished professor of biology, and Michael Ellison, a postdoctoral fellow in biology ?and with Michelle Vincler, Shannon Wittenauer and Renee Parker at the Wake Forest University School of Medicine in Winston-Salem, N.C.

The research was funded by the National Institutes of Health.

A Pain in the Nerves

The study dealt with what is known as neuropathic pain, which is chronic pain due to injury to the nerves, spinal cord or brain.

Such pain can result from diabetes damage to nerves in the feet or elsewhere, spinal injury, degenerative disc disease, alcoholism, failed low-back surgery, tumors compressing nerves, spinal tumors, repetitive motion disorders, multiple sclerosis, infection, stroke, traumatic brain injury, shingles, nerve toxins and electrical or other damage to peripheral nerves. Sometimes, doctors are unable to find a cause.

Symptoms can include numbness and pain that feels like constant burning, "pins and needles," sharp shooting pain, electricity or electrical shock, or tingling. People with neuropathic pain often are hypersensitive to previously innocuous stimuli ?for example, feeling pain from a foot rubbing against the inside of a shoe ?and feel an exaggerated response to things that are painful.

Common pain medicines like aspirin, ibuprofen and acetaminophen often fail to relieve neuropathic pain. Morphine-like opiods such as oxycodone sometimes are used, but can cause constipation, nausea and a spaced-out feeling.

Anticonvulsant drugs for epilepsy sometime are used to reduce the pain by decreasing nerve cell excitability, but have side effects such as lethargy, fatigue, clouding of mental state and weight gain, McIntosh says. Antidepressants and muscle relaxants have been used, but they can cause weight gain, nausea and sexual dys
'"/>

Source:University of Utah


Page: 1 2 3 4

Related biology news :

1. New binding target for oncogenic viral protein
2. Ancient olfaction protein is shared by many bugs, offering new pest control target
3. A bacterial genome reveals new targets to combat infectious disease
4. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
5. Researchers identify target for cancer drugs
6. Study reveals candidate targets for anti-retroviral therapeutics
7. MUHC researchers make cancer target breakthrough
8. Future diabetes drugs may target new protein interaction
9. Smart drug targets deadly brain cancer
10. NHGRI targets 12 more organisms for genome sequencing
11. While on trail of dioxin, scientists pinpoint cancer target of green tea
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new target for painkillers

(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 ... than the iPhone 5S, Samsung introduces for the ... The Galaxy S5 home button presents ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ... is accurate, flexible and robust – with the clinical ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... CORVALLIS, Ore. -- Zoologists at Oregon State University have ... fungal pathogen which is devastating amphibian populations around the world. ... provide a desperately needed tool for biological control of this ... efficacy in a natural setting. The fungus, B. ...
... PHOENIX, Ariz. Aug. 26, 2011 Waters Corporation ... Translational Genomics Research Institute (TGen) as a Waters Center ... Petritis, Head of TGen,s Center for Proteomics, and his ... and biomarker discovery and verification. In a ceremony ...
... obesity epidemic has been escalating for decades, yet long-term ... to a new paper from international public health experts ... journal The Lancet . Noting that many countries ... the authors call on governments around the world to ...
Cached Biology News:Possible biological control discovered for pathogen devastating amphibians 2TGen's Center for Proteomics selected as Waters Center of Innovation 2Government-led efforts targeting eating habits of children needed to curb worldwide obesity epidemic 2Government-led efforts targeting eating habits of children needed to curb worldwide obesity epidemic 3
(Date:12/17/2014)... Audacity, a leading California-based health and science ... Huntsworth Health Group, is proud to announce the addition ... role, Gonzales will serve as Senior Vice President of ... welcome a talent of Jamie’s caliber to the Audacity ... is a proven healthcare innovation leader and brand management ...
(Date:12/17/2014)... SILVER SPRING, Md. , Dec. 17, 2014 /PRNewswire/ ... today two senior executive promotions as well as changes ... Senior Executive Promotions United ... Ph.D. to President and Co-Chief Executive Officer and ... Chief Operating Officer.  In connection with these promotions, Dr. ...
(Date:12/17/2014)... Dec. 17, 2014 Tigercat Pharma, Inc. ... study evaluating the investigational oral NK-1 receptor antagonist ... severe, chronic itch who are unresponsive or inadequately ... topical steroids and antihistamines. The ... Analog Scale (VAS) itch score from baseline, comparing ...
(Date:12/15/2014)... December 15, 2014 METTLER TOLEDO ... PVM tool, ParticleView V19 with PVM technology ... probe-based particle vision and measurement tool continuously captures ... conditions. ParticleView V19 then automatically prepares a report ... particle size and concentration changes. This compelling blend ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ... been granted its 32nd U.S. Patent, # 7,582,289, entitled ... patent claims cover methods of using modified parapoxvirus orf ... expands our intellectual property portfolio regarding oncolytic viruses, in ...
... WILMINGTON, Delaware, September 1 ... (2009-2014), published,by MarketsandMarkets ( http://www.marketsandmarkets.com ), the total global,biomaterials ... 2014, growing,at a CAGR of 15.0% from 2009 to ... 42% of the total revenues. The biomaterials market today ...
... thorough, system-level assessment of the diversity of an ... Microbes belonging to that genus frequently participate in ... in the environment. The team of researchers ... University and the Pacific Northwest National Laboratory analyzed ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Issuance of 32nd U.S. Patent 2Global Biomaterials Market Worth US$58.1 Billion by 2014 2Global Biomaterials Market Worth US$58.1 Billion by 2014 3Hidden diversity in key environmental cleanup microbes found by systems biology assessment 2Hidden diversity in key environmental cleanup microbes found by systems biology assessment 3
Request Info...
... automated perfusion system. For real-time or ... biophysics, electrochemistry, or general liquid-handling research ... millisecond accuracy Run experiments automatically ... accuracy and flexibility Turnkey perfusion ...
Recombinant Human PTP1B (aa 2-321), CF...
... DuoSet ELISA Development kit contains the basic ... ELISAs to measure natural and recombinant rat ... serum. Each kit contains sufficient materials to ... provided that the following conditions are met: ...
Biology Products: