Navigation Links
A new step towards an AIDS vaccine

Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. High numbers of pDCs is related to successful control of HIV. In a paper appearing online on October 13 in advance of print publication of the November issue of the Journal of Clinical Investigation, Nina Bhardwaj and colleagues from New York University report the mechanisms by which HIV-1 activates human pDCs.

The authors show that pDC activation by HIV-1 requires at least two interactions between the cell and virus. Initially, envelope-CD4 interactions mediate the endocytosis of HIV-1. Next, viral nucleic acids, particularly RNA, stimulate pDCs through Toll-like receptors.

A decrease of blood pDC frequency is typically observed in chronic infections due to HIV-1 and correlates with high viral load, reduced CD4 counts and susceptibility to opportunistic infections, and is only partially reverted by anti-retroviral therapy. By identifying the active component of HIV-1 which stimulates pDC function, and consequently other antigen presenting cell function, the authors have recognized an important pathway whereby DC function can be targeted in the design of efficient vaccines or immunotherapies for HIV.


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Virologists make major step towards understanding the process of HIV infection
2. Cats indifference towards sugar explained
3. New GM mosquito sexing technique is step towards malaria control, report scientists
4. Novel method reveals how menthol discovery could point towards new or improved pain therapies
5. Scientists make first step towards holy grail of crystallography
6. Salk researchers make fast strides towards understanding how our body controls walking
7. Research advances quest for HIV-1 vaccine
8. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
9. NIAID begins clinical trial of West Nile virus vaccine
10. Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
11. Fragment of yellow fever virus may hold key to safer vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new step towards AIDS vaccine

(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
(Date:4/2/2015)... 2015 In the current ... outperforms the strongest competitors, showing outstanding performance in ... system is capable of a throughput of 5.000.000 ... to be ten times faster than most competitors ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) ...
(Date:4/2/2015)... April 2, 2015 According to ... attributed to somewhat higher than 125 MSEK. This exceeds ... report 2014 that revenues for Q1 2015 would be ... reported for Q4 2014. The operating result for the ... The complete interim report will as previously communicated be ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... (March 14, 2012) A research team has identified ... in gene expression, within reprogrammed skin cells. These signatures ... reprogrammed skin cells or induced pluripotent stem cells (iPSCs), ... how the expression of the protein is controlled brings ...
... A new research survey conducted by the Center for ... Center shows the Bangladeshi community in New York City experiences ... and lack of diabetes awareness. The study, published in the ... Health , also found the Bangladeshi community has an interest ...
... Scientists at Johannes Gutenberg University Mainz (JGU) in ... proteins. Detailed knowledge of the dynamics of proteins is ... that occur on the molecular level. To date, this ... with fluorescent substances, but unfortunately this changes the proteins ...
Cached Biology News:Epigenetic signatures direct the repair potential of reprogrammed cells 2New study shines light on barriers to diabetes care in NYC Bangladeshi community 2Gold nanoantennas detect proteins 2
(Date:5/21/2015)... Kingston, Ontario (PRWEB) May 21, 2015 ... entered into an exclusive North American distribution agreement ... microbiology testing system. , With more than 160 ... of products and services for laboratory and production ... choice, operational excellence and differentiated services to enable ...
(Date:5/20/2015)... DUBLIN , May 19, 2015 Research and ... addition of the "Global Cell Therapy Market Outlook ... Utilization of cell therapy in tissue and regenerative medicine ... are no other options which could help in the ... in this segment but they are unable to form ...
(Date:5/20/2015)... , May 20, 2015  Marc Tessier-Lavigne, president ... gift of $100 million from The Marie-Josée and ... new laboratory building that will be the centerpiece ... Marie-Josée and Henry R. Kravis Research Building, two ... Drive, spanning approximately three city blocks following the ...
(Date:5/20/2015)... TRIANGLE PARK, North Carolina , ... weltweit führende Unternehmen für klinische Logistik ... Finanzergebnisse für das Geschäftsjahr 2014, das ... und eingereicht. Das Unternehmen hat die ... Logo - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
Breaking Biology Technology:Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... 22 Techne Corporation,s,(Nasdaq: TECH ) consolidated net ... to $28.6 million or $.74 per diluted share,compared with ... quarter ended,September 30, 2007. Net earnings as a percentage ... of last year to 41.2% for the quarter ended,September ...
... Inc.,(Nasdaq: MDVN ) today announced that the ... its collaboration with,Pfizer Inc. expired on October 20, ... to jointly develop and commercialize,Dimebon for the treatment ... waiting period triggers an up-front payment to Medivation,of ...
... ,silent killers, such as ... Screenings provide potentially life-saving data, including actual images ... and their doctors ... Oct. 22 HealthYes!(TM), based in Austin,is a premier ...
Cached Biology Technology:Techne Corporation Releases Unaudited First Quarter Results for Fiscal Year 2009 2Techne Corporation Releases Unaudited First Quarter Results for Fiscal Year 2009 3Techne Corporation Releases Unaudited First Quarter Results for Fiscal Year 2009 4Techne Corporation Releases Unaudited First Quarter Results for Fiscal Year 2009 5Medivation Announces Expiration of Hart-Scott-Rodino Waiting Period for Collaboration With Pfizer 2HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 2HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 3HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 4HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 5HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 6HealthYes! - Premier Provider of Mobile Preventive Medical Screenings - Launches in Alamo City 7
Contained in EZ-Tn5™ Kits and are available separately for sequencing of an insertion site....
Request Info...
Rabbit polyclonal to Syntrophin alpha 1 ( Abpromise for all tested applications). entrezGeneID: 6640 SwissProtID: Q13424...
Mouse monoclonal [4i97] to HLA Class 1 A25 ( Abpromise for all tested applications). Antigen: Full length protein (Human): HLA Class 1 Antigen-A25. Swiss Protein ID: P18462...
Biology Products: