Navigation Links
A new mechanism of regulating RNA degradation

At first, we thought that gene expression was modulated only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA level is even more complex than we first imaginated...

As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery.

Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has garnered significant attention in recent years, and one that has the potential to produce a new set of tools for physicians to use to fight disease.

Most of the gene-control tools researchers have collected thus far involve the first step in gene expression, in which DNA is copied into RNA transcripts. However, recent discoveries have shown that many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself.

One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity.

To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical c
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3

Related biology news :

1. Plants, animals share molecular growth mechanisms
2. PET/MRI scans may help unravel mechanisms of prenatal drug damage
3. Researchers discover molecular mechanism that desensitizes us to cold
4. Chemists identify immune system mechanism for methamphetamine binges
5. Key mechanism in genetic inheritance during cell division identified
6. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
7. Mouse gene shows new mechanism behind cardiac infarction in man
8. UCSD research reveals mechanism involved with type of fatal epilepsy
9. Ancient immune defense mechanism is no match for HIV-1
10. Malaria mechanism revealed
11. Researchers discover mechanism for multiplying adult stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new mechanism regulating RNA degradation

(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
(Date:11/3/2014)... low birth weight and preterm birth are linked to ... Findings published in the American College of Rheumatology (ACR) ... low birth weight and pre-term babies were not at ... adults. , According to the ACR, 27 million ... clinical OA. Symptoms of OA range from mild to ...
(Date:11/2/2014)... ORLEANS, LA (2 November 2014)—In support of a bold ... Bill & Melinda Gates Foundation today announced an award ... Malaria Vaccine Initiative (MVI) in building new vaccines that ... help realize the "accelerating to zero" agenda. Such vaccines ... what could be called an "immunological bed net." ...
Breaking Biology News(10 mins):PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
... waste from nearby manufacturing plants flowed into the waters ... The harbor, which is contaminated with polychlorinated biphenyls (PCBs) ... Superfund cleanup sites. It,s also the site of ... Institution (WHOI) and their colleagues have been working to ...
... The rapid conversion of natural lands to cement-dominated urban centers ... new study involving 147 cities worldwide, surprisingly high numbers of ... environments to the tune of hundreds of bird species ... Contrary to conventional wisdom that cities are a wasteland for ...
... bags, an abundant source of litter on land and ... and other useful petroleum products, researchers report. The ... results in transportation fuels diesel, for example ... biodiesels. Other products, such as natural gas, naphtha (a ...
Cached Biology News:Solving an evolutionary puzzle 2Solving an evolutionary puzzle 3Solving an evolutionary puzzle 4Cities support more native biodiversity than previously thought 2Cities support more native biodiversity than previously thought 3Plastic shopping bags make a fine diesel fuel, researchers report 2
(Date:11/21/2014)... , Todd Martensen ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial ... en marcha para comenzar de forma rápida la comercialización de ... aprobación en Europa   , KLOX ... los siguientes nombramientos: Todd Martensen ha ...
(Date:11/21/2014)... Diego, CA (PRWEB) November 20, 2014 ... extended their Sartorius Entris Balance promotion . The ... customers seeking a durable, high accuracy, and easy-to-maintain balance ... made in Germany. It was designed to help customer’s ... affordable and a balance that is very durable. Sartorius ...
(Date:11/21/2014)... The report, "Synthetic Biology Market ... kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning ... - Global Forecast to 2018", analyses and ... and challenges. , Browse 99 market data ... pages and in-depth TOC of the global ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 Why did ... makes Albert Einstein so instantly recognizable? Why have they ... mathematician, astronomer and author Hilton Ratcliffe seeks out the ... nothing at all to do with science. In " ... Publishing , November 21, 2014), Ratcliffe puts it plainly: ...
Breaking Biology Technology:KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... Type III von Willebrand Disease, a serious, hereditary ... bleeding disorder, found in ... Behring today,announced that Iran,s Ministry of Health and Medical Education ... on an exclusive,basis throughout Iran, beginning immediately. Haemate P is ...
... Path for ... New Treatments, WILMINGTON, Del. and ... ) today announced,that they will collaborate to help advance understanding of Alzheimer,s,disease ... cutting-edge brain imaging methods., The new alliance will focus on the ...
... TUSTIN, Calif., Dec. 19 AMDL, Inc., (Amex:,ADL), ... a,developer, manufacturer, and marketer of pharmaceutical, nutraceutical,diagnostic, consumer ... open,its first large-scale JPGreen Health and Personal Care ... by Jade to be converted,into a flagship JPGreen ...
Cached Biology Technology:CSL Behring Expands Into Middle East Market with Haemate(R) P 2CSL Behring Expands Into Middle East Market with Haemate(R) P 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 2AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 4AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
... The 2/3D Waver Shaker combines shaking and ... with a 330 x 330 mm stainless steel ... top incubator and cold room operation. The platform ... degree for a vigorous with action and rotation ...
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
... The Experion HighSens analysis kit for 25 ... to perform high-sensitivity RNA analysis (at picogram ... This kit includes 25 RNA HighSens microfluidic ... 2 x 20 microliters RNA HighSens stain, ...
Biology Products: