Navigation Links
A new mechanism of regulating RNA degradation

At first, we thought that gene expression was modulated only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA level is even more complex than we first imaginated...

As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery.

Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has garnered significant attention in recent years, and one that has the potential to produce a new set of tools for physicians to use to fight disease.

Most of the gene-control tools researchers have collected thus far involve the first step in gene expression, in which DNA is copied into RNA transcripts. However, recent discoveries have shown that many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself.

One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity.

To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical c
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3

Related biology news :

1. Plants, animals share molecular growth mechanisms
2. PET/MRI scans may help unravel mechanisms of prenatal drug damage
3. Researchers discover molecular mechanism that desensitizes us to cold
4. Chemists identify immune system mechanism for methamphetamine binges
5. Key mechanism in genetic inheritance during cell division identified
6. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
7. Mouse gene shows new mechanism behind cardiac infarction in man
8. UCSD research reveals mechanism involved with type of fatal epilepsy
9. Ancient immune defense mechanism is no match for HIV-1
10. Malaria mechanism revealed
11. Researchers discover mechanism for multiplying adult stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new mechanism regulating RNA degradation

(Date:7/24/2014)... , July 24, 2014 NXT-ID, Inc., (NXTD: OTCQB) a ... announces its next generation smart wallet, Wocket™, was recently the topic ... Finley interviewed Gino Pereira , CEO of ... minutes. Mr. Gino Pereira ... full of credit cards and walks host Anita ...
(Date:7/23/2014)... -- Pfenex Inc. (NYSE MKT: PFNX) today announced the pricing ... common stock at a price to the public of $6.00 ... 30-day option to purchase up to 1,250,000 additional shares of ... are expected to begin trading on the NYSE MKT on ... William Blair & Company, L.L.C. and JMP Securities LLC ...
(Date:7/23/2014)... or neglected early in life are at risk ... In a new study, scientists have found that ... has implications for children,s long-term development. Previous studies ... and genetics interacted with that child,s experiences in ... In the new study, researchers were able to ...
Breaking Biology News(10 mins):Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 2Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 4Pfenex Inc. Announces Pricing Of Initial Public Offering 2Stress tied to change in children's gene expression related to emotion regulation, physical health 2Stress tied to change in children's gene expression related to emotion regulation, physical health 3
... -- An Illinois research team has succeeded in ... that simultaneously reduces atmospheric carbon dioxide and produces ... engineering professor Paul Kenis and his research group ... startup company, to produce a catalyst that improves ...
... New Rochelle, NY, October 6, 2011Measurable changes in brain ... consequence of virus-induced injury during the early stages of ... implications in disease prognosis are detailed in an article ... Connectivity , a bimonthly peer-reviewed journal published by ...
... new research program funded by the National Institutes of ... has on human health. Led by NIH,s National Institute ... the risk factors that make people more vulnerable to ... such as air pollution and toxic chemicals; and the ...
Cached Biology News:Ionic liquid catalyst helps turn emissions into fuel 2Changes in brain function in early HIV infection: A reliable indicator of disease prognosis? 2NIH launches research program to explore health effects from climate change 2NIH launches research program to explore health effects from climate change 3
(Date:7/24/2014)... July 24, 2014 1000 balances – ... input on customers’ weighing needs and expertly narrows down ... of balances, scales or even terminals. , First, ... smallest weight (or select readability instead) and define the ... additional selection criteria narrows down the list to models ...
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/23/2014)... Arab Emirates (UAE) (PRWEB) July 23, 2014 ... Century recently announced that its biobanking project, ... , Ph.D. to its growing Advisory Board. Scott ... very pleased to have Dr. Vaught onboard with Provia’s ... depth and expertise that Provia’s management team brings to ...
(Date:7/23/2014)... Dresden-Rossendorf (HZDR), the Vienna University of Technology and ... embedding nearly perfect semiconductor crystals into a silicon ... nanowires, very fast and multi-functional processing units can ... future. The research results will be published in ... are considered the cornerstone of future chip technology, ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4A crystal wedding in the nanocosmos 2
... SETAUKET, N.Y., May 25, 2011 John S. Kovach, ... Biotechnology Holdings, Inc. (LIXT.PK), announces the appointment of  Robert ... of Directors. Dr. Royds is Chair of ... a leading clinical research organization, which he founded in ...
... a Phase 2 multicenter, randomized, double-blind, proof-of-concept and ... 136) improved signs and symptoms of rheumatoid arthritis ... with methotrexate (MTX).  Findings from Part A of ... League Against Rheumatism (EULAR) Congress showed that a ...
... May 25, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... today jointly announced that Watson has acquired the ... for EUR 400 million ($562 million) in cash ... the acquisition, Watson gains a leading generic product ...
Cached Biology Technology:Lixte Biotechnology Holdings Announces New Appointment to Board of Directors 2Lixte Biotechnology Holdings Announces New Appointment to Board of Directors 3Interleukin-6 Inhibitor Sirukumab (CNTO 136) Phase 2 Data Show Promise in the Treatment of Active Rheumatoid Arthritis 2Interleukin-6 Inhibitor Sirukumab (CNTO 136) Phase 2 Data Show Promise in the Treatment of Active Rheumatoid Arthritis 3Interleukin-6 Inhibitor Sirukumab (CNTO 136) Phase 2 Data Show Promise in the Treatment of Active Rheumatoid Arthritis 4Watson Acquires Specifar Pharmaceuticals 2Watson Acquires Specifar Pharmaceuticals 3Watson Acquires Specifar Pharmaceuticals 4Watson Acquires Specifar Pharmaceuticals 5Watson Acquires Specifar Pharmaceuticals 6
... Synaptogyrin 2 ( Abpromise ... Antigen: Synthetic ... sequence amino acids 42-57 of ... Entrez Gene ID: ...
Rabbit polyclonal to SMURF 2 ( Abpromise for all tested applications). Antigen: A KLH conjugated synthetic peptide (10-30 aa in length) at the N-term of first 50 aa of human SMURF 2. Entrez G...
Rabbit polyclonal antibody to NCOA2 [Agarose Immobilized]...
Rabbit anti Mouse ZIC2 Preservative: NaN3...
Biology Products: