Navigation Links
A new mechanism of regulating RNA degradation

At first, we thought that gene expression was modulated only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA level is even more complex than we first imaginated...

As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery.

Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has garnered significant attention in recent years, and one that has the potential to produce a new set of tools for physicians to use to fight disease.

Most of the gene-control tools researchers have collected thus far involve the first step in gene expression, in which DNA is copied into RNA transcripts. However, recent discoveries have shown that many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself.

One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity.

To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical c
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3

Related biology news :

1. Plants, animals share molecular growth mechanisms
2. PET/MRI scans may help unravel mechanisms of prenatal drug damage
3. Researchers discover molecular mechanism that desensitizes us to cold
4. Chemists identify immune system mechanism for methamphetamine binges
5. Key mechanism in genetic inheritance during cell division identified
6. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
7. Mouse gene shows new mechanism behind cardiac infarction in man
8. UCSD research reveals mechanism involved with type of fatal epilepsy
9. Ancient immune defense mechanism is no match for HIV-1
10. Malaria mechanism revealed
11. Researchers discover mechanism for multiplying adult stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new mechanism regulating RNA degradation

(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
(Date:5/8/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... of the executive management team will present at the following ... and Telecom Conference Date: May 18, 2015 Time: ... MA Cowen and Company Technology, Media ... Location: The New York Palace Hotel, New York, ...
(Date:5/5/2015)... 2015, NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, reminds investors and media that  Mr. ... presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held in ... The three-day conference is organized into a series of ... themed Global Fraud: Where is the Trust in Cyberspace? ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Synaptics to Present at Upcoming Investor Conferences 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... piece of information to be of any use, one must first ... Nowadays, there is often just too much of it. We are ... night, assisting us to find, digest and comprehend it. In this ... for a barrier-free accessibility of content that can be harvested, extracted, ...
... tiny goggles, scientists say they have learned that the ... stimuli, but also can "learn" time intervals and create ... a team at the Johns Hopkins University School of ... light on learning and memory-making, the investigators say, and ...
... and Ghent, Belgium, January 23, 2013 Hundreds of ... scheduled to convene in Ghent, Belgium, from June 25-28 ... (ICG-Europe 2013). The conference, co-organized by BGI and VIB, ... in plant and animal genomics, metagenomics, as well as ...
Cached Biology News:Pensoft Publishers integrate their journal platform with OpenAIRE 2Pavlov's rats? Rodents trained to link rewards to visual cues 2Pavlov's rats? Rodents trained to link rewards to visual cues 3Pavlov's rats? Rodents trained to link rewards to visual cues 4The 2013 International Conference on Genomics in Europe will take place in Ghent, Belgium 2
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... 2015 Patent Offering, The patent’s technology ... or therapeutic imaging within a body lumen (open space). ... having a low cost, single-use disposable illumination and camera ... October 18, 2013 and the patent approval was received ... physician to customize the lighting and magnification of the ...
(Date:5/21/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: ... on the development of autologous cell therapies, announced ... Society for Cellular Therapy (ISCT) on RepliCel,s autologous ... a Phase 1/2 clinical trial.  The presentation, taking ... PM to 7:00 PM local time, will review ...
(Date:5/20/2015)... 20, 2015 Research and Markets ( ... "Top Technologies in HW_Technical Insights" report to their ... evaluated technology trends in the Health and Wellness sector ... to have an impact in the year 2015. The ... top 10 health and wellness technologies that are anticipated ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Top Technologies in the Health and Wellness Industry 2015 2
... KUNMING, China, Nov. 12 /Xinhua-PRNewswire-FirstCall/ -- China ... ("China Shenghuo" or the,"Company"), which is engaged ... pharmaceutical, nutritional supplement and cosmetic products,in the ... the NYSE Alternext,US LLC (formerly the American ...
... Pa., Nov. 12 GEL Interactive,Technologies, a Cadient ... Director, will be a featured speaker at the ... on Defining Appropriate,and Effective Interactions with Thought Leaders ... Forum provides a platform for attendees to interact,and ...
... Nov. 12 Phosphagenics,Limited ("Phosphagenics") (ASX: POH; OTCQX: ... phase 1 human clinical trial using its ... delivery of a leading non steroidal,anti-inflammatory drug ... and penetration of the topically applied Voltaren(R) ...
Cached Biology Technology:NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 2NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 3NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 4Cadient Group's GEL Interactive Technologies to Present and Exhibit at CBI's 5th Annual Forum 2Transdermal Diclofenac enters Phase 1 Clinical Trial in Humans 2
The HQ505, 20 OptiGreen filter for the Molecular Imager FX is a band pass filter used for detection of Cy2 and FITC with 532 nm excitation....
... The APO-BRDU Kit is a 2-color staining ... cellular DNA to detect apoptotic cells by ... and reagents required for measuring apoptosis in ... for assessing reagent performance; washing, reaction and ...
... The ApopTag Red In Situ ... situ by the indirect TUNEL method, ... rhodamine fluorochrome. The kit provides indirect ... are analyzed using either fluorescence microscopy ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
Biology Products: