Navigation Links
A new kind of mutation could explain numerous phenotypic variations in various species

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep.

A mechanism observed in other species as well

However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species ?among which humans ?including the hereditary predisposition to various diseases.

Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.


'"/>

Source:University of Liege


Page: 1

Related biology news :

1. Novel technology detects human DNA mutations
2. Fox Chase Cancer Center scientists identify immune-system mutation
3. Mitochondrial DNA mutations play significant role in prostate cancer
4. Same mutation aided evolution in many fish species, Stanford study finds
5. Bioelectronic ‘signatures?hold key to DNA mutations
6. Sugar beet virus mutation requires Texas touch
7. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
8. Treatments have same target, different responses for lung cancer patients with genetic mutation
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. DNA size a crucial factor in genetic mutations, study finds
11. Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg Instruments, ... latest technology innovation for its Volume Pattern Generator (VPG) line of lithography systems. ... advanced photomasks as well as a solution for mid volume direct write lithography ...
(Date:4/26/2016)... Washington (PRWEB) , ... April 26, 2016 , ... ... today announced receipt of a significant operating grant from 1Plus12 Corporation. The grant ... to commence pre-proposal activities as outlined on the organization's website http://www.ivsci.org ...
(Date:4/26/2016)... 26, 2016 genae, a Contract ... industries, announced today the appointment of Prof. Dr. Jörn ... Balzer,s responsibilities will include all clinical, safety and risk ... feel privileged and honored with the acceptance of Prof. ... , CEO at genae. "Prof. Balzer,s impressive and extensive ...
(Date:4/26/2016)... ... April 26, 2016 , ... Smarter Alloys™ ... SmartArch is available for purchase in the United States through the official online ... with our partners, we’re excited to finally make the most advanced archwire in ...
Breaking Biology Technology: