Navigation Links
A new kind of mutation could explain numerous phenotypic variations in various species

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep.

A mechanism observed in other species as well

However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species ?among which humans ?including the hereditary predisposition to various diseases.

Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.


'"/>

Source:University of Liege


Page: 1

Related biology news :

1. Novel technology detects human DNA mutations
2. Fox Chase Cancer Center scientists identify immune-system mutation
3. Mitochondrial DNA mutations play significant role in prostate cancer
4. Same mutation aided evolution in many fish species, Stanford study finds
5. Bioelectronic ‘signatures?hold key to DNA mutations
6. Sugar beet virus mutation requires Texas touch
7. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
8. Treatments have same target, different responses for lung cancer patients with genetic mutation
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. DNA size a crucial factor in genetic mutations, study finds
11. Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:5/11/2017)... , May 11, 2017   BioLife Solutions , Inc. ... marketer of proprietary clinical grade cell and tissue hypothermic ... the "Company"), today reported operational highlights and financial results for ... media product sales reached a new high of $2.4 million ... over the same period in 2016. Revenue growth was driven ...
(Date:5/11/2017)... Linda, Ca (PRWEB) , ... May 11, 2017 ... ... and primary rodent neurons both are excellent resources for disease modeling and drug ... and further differentiated into mature neurons for various applications, however, these often contain ...
(Date:5/10/2017)... ... May 10, 2017 , ... Shimadzu Scientific Instruments (SSI) ... host of technologically advanced features, resulting in a modernized instrument that improves user ... a higher return on investment. , Engineered with the analyst in mind, ...
(Date:5/10/2017)... ... May 10, 2017 , ... ... Center as VP Corporate Development. Cervantes brings over 20 years’ experience in ... and academic research environments. , In this newly created position at the ...
Breaking Biology Technology: