Navigation Links
A new focus for the mechanism of nerve growth

Researchers at Yale shed new light on the mechanism of nerve cell growth by identifying novel functions for a molecular "motor" protein, myosin-II, according to an article in the March issue of Nature Cell Biology.

As nerve cells develop or attempt to recover after damage, they extend growth cones, highly flexible extensions that act as environmental sensors. Growth cones use the information they gather to direct advance of the nerve cells and it has long been known that such advance depends on the coordinated assembly of actin filament networks.

This study implicates the molecular motor, myosin II, as a key part of the process of recycling the actin networks and ultimately sensing and directing nerve growth.

Proteins in the Myosin family function as molecular motors; the most familiar myosins power contraction in heart and skeletal muscles. Myosin II motors are involved in functions such as directed cell movement, cell division and wound closure. While skeletal myosins have been studied in detail, non-muscle myosins are just beginning to be understood and this work identifies a new role for them.

The researchers, led by Paul Forscher, professor of molecular, cellular and developmental biology at Yale used a technique called fluorescent speckle microscopy, or FSM, that let them directly see actin filament assembly, disassembly and movement in living cells. They used FSM to monitor actin dynamics in nerve cells treated with a new drug called blebbistatin, that relaxes non-muscle myosin II and effectively blocks processes such as cell division.

"Past research has focused on how actin structures are assembled at the leading edges of motile cells," said Forscher. "Instead, this paper investigates turnover or recycling of the actin networks. As the complement to actin network assembly, recycling is necessary t
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Supercomputers to focus brains on AIDS dilemma
2. Study of energy and health in Africa focuses spotlight on charcoal and forest management
3. Scientists focus on dwarf eye
4. NIH renews network focused on how genes influence drug responses
5. WCS says avian flu prevention should focus on farms, markets
6. Brains response to visual stimuli helps us to focus on what we should see, rather than all there is to see
7. Report focuses on challenges to unlocking future promise of vaccines
8. First encyclopedia of nuclear receptors reveals organisms focus on sex, food
9. New light microscope sharpens scientists focus
10. Reversing hibernating heart muscle focus of UB researchers
11. Report focuses on the role good microbes play in future medicine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new focus for the mechanism nerve growth

(Date:4/17/2014)... of forests in the Amazon help create tinderbox ... rapid and widespread forest loss during drought years, ... show that forests in the Amazon could reach ... forest fires lead to large-scale loss of trees, ... professor of geography, Penn State. , "We documented ...
(Date:4/17/2014)... IPCC meeting painted a stark warning on the possible ... a greenhouse effect 32 times that of carbon dioxide. ... humic substances act as fully regenerable electron acceptors which ... in wetlands instead of being released to the atmosphere. ... disrupted it may enter into a vicious cycle to ...
(Date:4/17/2014)... is the process whereby the genetic information of ... as proteins, which have numerous different functions in ... important intermediary during gene expression, by relating the ... involved in manufacturing proteins. , By examining ... present in an organism at a given time, ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Rapid and accurate mRNA detection in plant tissues 2
... goats and other animals that have suffered from neglect, according ... In this first scientific study of rescued animals, the researchers ... poor welfare, such as inappropriate diet, and lack of space ... spatial awareness test, which involved giving the animals an opportunity ...
... special issue of Technology and Innovation ... ), devoted to studies on medical technology and health ... from new technologies to reduce the cost of health ... special issue of Technology and Innovation on ...
... gas development expands nationwide, policymakers, communities and public health ... as a means of predicting the effects of drilling ... the Colorado School of Public Health. The report, ... Public Health , highlights lessons learned when scientists from ...
Cached Biology News:Rescue me: New study finds animals do recover from neglect 2Technology transforms health care 2Technology transforms health care 3Health impact assessments prove critical public health tool 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
(Date:1/14/2014)... WASHINGTON , Jan. 14, 2014  3D Communications, a leading provider ... scientific, regulatory, business, and media events in the United ... its former associate Virginia Cox , JD, is returning to ... Virginia Cox re-joins 3D after more than two years ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... Calif., June 2 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... will present a company update at the Goldman Sachs 30th Annual ... 2009 at 9:00 a.m. ET. , , Interested ... via the investor section of the BioMarin website, www.BMRN.com ...
... , SAN DIEGO, June 2 Orexigen(R) Therapeutics, Inc. (Nasdaq: ... treatment of obesity, today announced the schedule of its upcoming ... the American Diabetes Association (ADA) 69th Scientific Sessions, June 5-9, ... (ENDO), June 10-13, 2009. , , , ...
... June 2 Micromet, Inc. (Nasdaq: MITI ), a ... inflammation and autoimmune diseases, today announced that it will host a ... on June 5th and 6th at the 14th Congress of the ... company,s website at www.micromet-inc.com . , , ...
Cached Biology Technology:BioMarin to Present at the Goldman Sachs Healthcare Conference 2Orexigen(R) Therapeutics Announces Upcoming Data Presentations at American Diabetes Association and Endocrine Society Annual Scientific Meetings 2Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 2Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 3Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 4
ANTI MYCOBACTERIUM TUBERCULOSIS...
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
Biology Products: