Navigation Links
A natural chemical found in strawberries boosts memory in healthy mice

call "long-term potentiation" or LTP. LTP allows memories to be stored in the brain by strengthening connections between neurons. "We wanted to find out whether we could detect any effects of fisetin on long-term potentiation and the formation of memories in animals," Maher recalls.

Since the hippocampus plays an important role in establishing new memories, Maher, and co-authors Tatsuhiro Akaishi and Kazuho Abe, both at Musashino University in Tokyo, Japan, extended the study and found that fisetin activates the same signaling pathway in rat hippocampal tissues and also induces LTP.

Next, they tested fisetin's effects in a so-called object discrimination test in mice. The mice get to explore two objects for a certain amount of time. The next day, one of the objects is replaced with a novel one. If the mice remember the object from the day before, they spend less time exploring the old one and instead turn their attention to the novel object. Indeed, mice administered a single dose of fisetin could better recall familiar objects. In fact, fisetin worked almost as well as rolipram, a substance known to enhance memory.

Memory loss caused by neurodegenerative disease occurs due to loss of neurons, a situation very different from that of healthy mice. Thus the ultimate goal is to stop neuronal loss. Nevertheless, memory-enhancing drugs can improve Alzheimer's disease symptoms.

The observations that fisetin protects and promotes survival of cultured neurons and boosts memory in healthy mice make it a promising candidate for further studies. Notes Maher, "This is the first time that the function of a defined natural product has been characterized at the molecular level in the central nervous system and also shown to enhance both LTP in vitro and long-term memory in vivo."

"The good news is that fisetin is readily available in strawberries but the bad news is that because of its natural product status there may be little fin
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. UCLA scientists store materials in cells natural vaults
5. Man-made wetlands effectiveness similar to natural marsh
6. Researchers pioneer new gene therapy technique using natural repair process
7. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
8. Cornell finds natural selection in humans
9. Oysters: The natural way to protect our shores
10. New discovery: Molecular variation in one gene affects the growth of natural populations
11. Common bacteria pirate natural mechanism to get inside cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: natural chemical found strawberries boosts memory healthy mice

(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... England , November 4, 2014 ... and vertical market growth   Fuel3D , ... has closed a funding round totaling $6.4 million (£4 million). ... million) funding secured earlier this year and paves the way ... in 2015. The funding round was led by ...
(Date:11/3/2014)... DUBLIN , Nov. 3, 2014 Research ... report "Cell Therapy - Technologies, Markets and Companies" ... evaluates cell therapy technologies and methods, which have already started ... Hematopoietic stem cell transplantation is replacing the old fashioned bone ... described. Cell therapy is bound to become a part of ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... indicates that wild salmon may account for just 10 ... vast majority of the fish come from hatcheries. The ... decline in the population this year, which will probably ... and recreational salmon fishing. The role of ...
... 15 years of biodiversity and climate change research ... announced formation of its Asia Center to forge ... use of environmental resources. One of the first ... Philadelphia, is with Nanjing University, one of the ...
... Inzana, the Tyler J. and Frances F. Young Professor ... Pathobiology in the Virginia-Maryland Regional College of Veterinary Medicine ... the United States Department of Agriculture to study the ... Disease Complex (BRDC). The $374,000 grant will allow ...
Cached Biology News:Hatchery fish outnumber wild chinook salmon in troubled fall run 2Hatchery fish outnumber wild chinook salmon in troubled fall run 3Hatchery fish outnumber wild chinook salmon in troubled fall run 4Hatchery fish outnumber wild chinook salmon in troubled fall run 5Academy establishes Asia Center to protect the environment 2Academy establishes Asia Center to protect the environment 3Academy establishes Asia Center to protect the environment 4Veterinary college researchers explore function of biofilm in bovine respiratory disease 2
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
(Date:11/22/2014)... 2014 Two new educational webinars hosted by ... for ALS research and how the pharmaceutical industry can make ... Bucket Challenge: Where Does the ALS Money Go? , Featuring ... 2014, Time: 1:30pm ET, Register to attend , ... Merit Cudkowicz, Julianne Dorn Professor of Neurology at Massachusetts General ...
(Date:11/22/2014)... Prominent academics, leaders of the ... December 3rd at Genetic Rx, a networking conference ... take place at the Joseph B. Martin Conference ... the present and future of genetic medicines—including siRNA, ... editing—as well as the treatment of patients with ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
Breaking Biology Technology:Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2RURO Announces Limfinity® version 5.1.4 2
... /PRNewswire-FirstCall/ - The Board of Directors of,Neptune ... decided,not to re-price any options including the ... directors., About Neptune Technologies, Neptune ... for nutraceutical and pharmaceutical applications and is,sponsoring ...
... Trusted LASIK Surgeons launched its revolutionary Trusted LASIK Surgeons ... order to provide a resource for consumers seeking to ... directory apart is a unique screening process ensuring that ... Eye Surgery, Laser Surgeons in the United States are ...
... Shareholders to Reject Entire Management,Slate of InSite Vision, ... AUSTIN, Texas and HOUSTON, Sept. 11 PTV ... firm, is pleased to,announce that RiskMetrics Group -(Formerly ... corporate governance firm, recommended that the,stockholders of InSite ...
Cached Biology Technology:Neptune Technologies decided not to re-price options 2Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 2Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 3Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 4Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 5Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 6Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 7RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 2RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 3RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 4
... The enzyme glycerol 3-phosphate dehydrogenase ... phosphate (DHAP) and glycerol 3-phosphate, with ... increases significantly during differentiation of progenitor ... activity of this enzyme has been ...
... with an Affinity Chitin-binding Tag) utilizes the ... elements (termed inteins) to purify recombinant proteins ... 1 and 2). This system distinguishes itself ... ability to separate a recombinant protein from ...
... pET Host Strain Competent Cell Sets ... optimizing vector/host strain combinations The ... into E. coli is to ... can be prepared in the laboratory, greater ...
... EZ DNA Methylation Kit uses a simplified ... DNA methylation analysis. The kit is based ... place between cytosine and sodium bisulfite where ... DNA Methylation Kits innovative in-column desulphonation reaction ...
Biology Products: