Navigation Links
A large step forward in the fight against African sleeping sickness

Each year, over 300,000 people die of African sleeping sickness (trypanosomiasis). Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Free University of Brussels are making strides in the battle against this disease.

They have coupled the human protein ApoL-1 with a nanobody in order to very specifically eliminate the infection caused by the pathogenic parasites, against which our defense mechanism is powerless. Tests on mice are already promising. The recently published research results offer new possibilities for people who have contracted this disease.>African sleeping sickness
About 400,000 people worldwide suffer from the deadly African sleeping sickness. The disease produces severe sleep disorders that ultimately end in coma, followed by death. At present, fewer than 10% of the patients are treated in time. But on the other hand, the current treatment is also very toxic, and in many cases also results in the patient's death.

African sleeping sickness is a disorder caused by the trypanosome parasite. The blood-sucking tsetse fly transmits the parasite from person to person. Once someone has been infected by the parasite, the person's body has great difficulty getting the infection under control, because the parasite constantly changes appearance. Thus, the trypanosome remains impervious to the antibodies that the body produces.

Parasite eludes human defense mechanism
Fortunately, our body has a special defense mechanism that can help us in the fight against African trypanosomes. Our blood contains ApoL-1, which is toxic to − and neutralizes − most types of trypanosomes.

However, there is one trypanosome against which we are not protected: Trypanosoma brucei rhodesiense. This parasite is resistant to ApoL-1, because it has particular proteins that counteract ApoL-1's action.

For some time now, scientists have known that a variant of ApoL-1 i
'"/>

Source:VIB, Flanders Interuniversity Institute of Biotechnology


Page: 1 2

Related biology news :

1. Scientists discover unique microbe in Californias largest lake
2. Worlds largest rainforest drying experiment completes first phase
3. NASA study finds snow melt causes large ocean plant blooms
4. New project aims to make large-scale lobster farms feasible
5. Butterfly migration could be largest known
6. Amazon symposium to address large-scale conservation
7. Inhaling large amounts of salt can cause hypertension
8. Size matters: Preventing large mammal extinction
9. Carnegie Mellon University research reveals how cells process large genes
10. Updated data on novel HPV vaccine confirms efficacy in large population
11. Free-energy theory borne out in large-scale protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: large step forward the fight against African sleeping sickness

(Date:7/10/2014)... Axinaea belongs to the large, mainly tropical flowering plant ... species in the family rely on bees for their pollination. ... insects or vertebrates. The flowers of Axinaea appear ... the petals of the different species are pink, yellow, orange ... on the contrasting colours of their bulbous appendages. The pollination ...
(Date:7/10/2014)... ocean as a microbial megacity, teeming with life too ... hundreds of types of bacteria can be found. ... microbes have their own daily cyclesnot unlike the residents ... commute, work, and eat at the same times., What,s ... that need solar energy to help them photosynthesize food ...
(Date:7/10/2014)... Endomedix, a start-up company housed at NJIT,s business incubator, ... spray-on gel that surgeons will use to staunch bleeding ... onto a surgical site, and the natural bio-polymer solutions ... the patient within 30 seconds. , The gel ... It will translate into less time for the patient,s ...
Breaking Biology News(10 mins):Novel type of bird pollination mechanism discovered in South America 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3A start-up at NJIT develops bleeding-control gel for brain surgery 2
... Drug Administration (FDA) today issued a public health advisory ... to new safety information concerning an unapproved (i.e., "off-label") ... drugs are approved for the treatment of schizophrenia and ... behavioral disorders in elderly patients with dementia have shown ...
... versatile microorganisms ?a bacterium called Pseudomonas putida ?could ... the destruction of the chemical weapon mustard, write ... Biotechnology (http://www.interscience.wiley.com/jctb) this month. , At 40,000 tonnes, ... warfare agents (CWAs). The country faces a race ...
... traveler's diarrhea cases among U.S. travelers to Mexico ... cause of nonbacterial gastroenteritis outbreaks usually associated with ... researchers at the Johns Hopkins Bloomberg School of ... found that the longer travelers stayed at their ...
Cached Biology News:FDA Warns About Antipsychotic Drugs and Elderly 2Could microbes solve Russia's chemical weapons conundrum? 2Norovirus found to cause traveler's diarrhea 2
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... recent study by researchers at the University of ... physical mechanisms governing the interplay of spin and ... limits of ultrafast spintronic devices for data storage ... charge as well as spin-angular momentum. In a ... there is no spin current," explained David Cahill, ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3
... A friend of mine at a small college once threw a ... the evening, my friends 10-year old daughter was presented and asked ... was Aren-kay Iller-may, sure that her recently learned pig Latin was ... As a consultant who sees a lot of interactions between technologists ...
... health will address how IT can be leveraged to improve ... the nation in this effort. , ,MADISON - The ... of data lead to as many as 100,000 deaths each ... Network will host their 2nd Annual Digital Healthcare Conference ...
... University of Wisconsin-Madison Department of Educational Psychology has teamed ... Learning Co-Lab to create new worlds in which ... ,"The Department's Learning Sciences Program studies how ... professor in UW-Madison's School of Education. "We have made ...
Cached Biology Technology:Echnology-tay Eak-spay 2Echnology-tay Eak-spay 3Wisconsin Technology Network presents symposium on saving lives by the use of Information Technology 2Wisconsin Technology Network presents symposium on saving lives by the use of Information Technology 3University of Wisconsin team creates learning games 2University of Wisconsin team creates learning games 3
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
... its effects by binding ... a disulfide-linked heterotetrameric protein ... subunits and two Beta ... following configuration: Beta-Alpha-Alpha-Beta. ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Mfr ...
... 11, Compliant software for JASCO HPLC systems. , Integrated Instrument ... EZChrom Elite ... options for JASCO HPLC systems. This provides a completely integrated system ... settings with each run. , ...
Biology Products: