Navigation Links
A large step forward in the fight against African sleeping sickness

Each year, over 300,000 people die of African sleeping sickness (trypanosomiasis). Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Free University of Brussels are making strides in the battle against this disease.

They have coupled the human protein ApoL-1 with a nanobody in order to very specifically eliminate the infection caused by the pathogenic parasites, against which our defense mechanism is powerless. Tests on mice are already promising. The recently published research results offer new possibilities for people who have contracted this disease.>African sleeping sickness
About 400,000 people worldwide suffer from the deadly African sleeping sickness. The disease produces severe sleep disorders that ultimately end in coma, followed by death. At present, fewer than 10% of the patients are treated in time. But on the other hand, the current treatment is also very toxic, and in many cases also results in the patient's death.

African sleeping sickness is a disorder caused by the trypanosome parasite. The blood-sucking tsetse fly transmits the parasite from person to person. Once someone has been infected by the parasite, the person's body has great difficulty getting the infection under control, because the parasite constantly changes appearance. Thus, the trypanosome remains impervious to the antibodies that the body produces.

Parasite eludes human defense mechanism
Fortunately, our body has a special defense mechanism that can help us in the fight against African trypanosomes. Our blood contains ApoL-1, which is toxic to − and neutralizes − most types of trypanosomes.

However, there is one trypanosome against which we are not protected: Trypanosoma brucei rhodesiense. This parasite is resistant to ApoL-1, because it has particular proteins that counteract ApoL-1's action.

For some time now, scientists have known that a variant of ApoL-1 i
'"/>

Source:VIB, Flanders Interuniversity Institute of Biotechnology


Page: 1 2

Related biology news :

1. Scientists discover unique microbe in Californias largest lake
2. Worlds largest rainforest drying experiment completes first phase
3. NASA study finds snow melt causes large ocean plant blooms
4. New project aims to make large-scale lobster farms feasible
5. Butterfly migration could be largest known
6. Amazon symposium to address large-scale conservation
7. Inhaling large amounts of salt can cause hypertension
8. Size matters: Preventing large mammal extinction
9. Carnegie Mellon University research reveals how cells process large genes
10. Updated data on novel HPV vaccine confirms efficacy in large population
11. Free-energy theory borne out in large-scale protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: large step forward the fight against African sleeping sickness

(Date:9/18/2014)... millions of Americans to undertake jaunts into the countryside each ... longer within a century, according to new research. , Climate ... the United States as summer temperatures linger later into the ... Ecology and Biogeography . For instance, the paper birch ... New Hampshire could change color one to three weeks ...
(Date:9/18/2014)... colleagues have built the first smartphone app that ... behavioral trends. In other words, your smartphone knows ... don,t -- and how that affects you. , ... depression and loneliness to their academic performance, also ... for example, to monitor mental health, trigger intervention ...
(Date:9/18/2014)... seem to be cheerful, happy-go-lucky characters, so you might ... life. , In fact some dogs are distinctly ... Sydney shows. , "This research is exciting because ... objectively and non-invasively. It offers researchers and dog owners ... that changes," said Dr Melissa Starling, from the Faculty ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Dogs can be pessimists too 2Dogs can be pessimists too 3
... Mich. A new study finds that African ancestry ... type of cancer that has fewer treatment options. ... found that, among women with breast cancer, 82 percent ... African-Americans were and 16 percent of white Americans were. ...
... crocodiles and navigating around massive submerged trees, a team ... pools of Cara Blanca, Belize, which were important to ... divers found fossilized animal remains, bits of pottery and ... underwater cave. [Click here to see a ...
... years ago when the American Society for Cell Biology (ASCB) ... This year over 7,000 scientists from throughout the world ... Dec. 11 to 15 for ASCB,s 50th Annual Meeting. ... research on the cell, ASCB,s conferences are the largest yearly ...
Cached Biology News:Study links African ancestry to high-risk breast cancer 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 3Cell biology society celebrates 50th 2
(Date:9/19/2014)... 2014 Cereal grain scientists, quality ... gather October 5–8, 2014, for the AACC International ... Center in Providence, Rhode Island. The comprehensive scientific ... food scientists, chemists, microbiologists, nutritionists, and those interested ... management. To date, 1,000 attendees have registered for ...
(Date:9/18/2014)... Washington, USA (PRWEB) September 18, 2014 ... Representatives of a bill designed to stimulate development and ... jobs is being praised by leaders of SPIE, ... bill, the Revitalizing American Manufacturing and Innovation (RAMI) Act, ... The bill’s authors have said they are optimistic that ...
(Date:9/18/2014)... 2014 A novel robotic system that ... is currently being tested as part of a biomedical ... Boston with the aim of determining if the robot, ... cancer biopsies faster, more accurate, less costly, and less ... the potential to deliver prostate cancer therapies with greater ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest Moniz joined ... Lab Day on the Hill. The event highlighted several ... Durbin and Risch also formally launched the Senate National ... reach of the national labs as leaders in developing ... our nation's most pressing challenges. , "The national labs ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... ATLANTA, Sept. 29, 2011 GeoVax Labs, Inc. (OTCQB/OTCBB: ... and fight Human Immunodeficiency Virus (HIV) infections, announces that ... to receive academic honors on September 26 and October ... Officer Harriet L. Robinson, PhD, was honored as a ...
... as a symbol of long-lasting love. But semiconductor makers ... of long-lasting micromachines if a new method developed at ... carving these tough, capable crystals proves its worth.* The ... in a diamond surface, yielding potential benefits in both ...
... PLC (AIM: GTL) today conducted its annual meeting in London, ... Henderson, the non-executive chairman of the U.S. based bio-refining company, ... "GTL is pleased to report that margins ... period ending September 30, 2011 closely tracked the seasonal margins ...
Cached Biology Technology:GeoVax Labs' CSO and Chairman Receive Academic Honors 2GeoVax Labs' CSO and Chairman Receive Academic Honors 3NIST polishes method for creating tiny diamond machines 2
CD69/CD3 50 tests...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rat polyclonal to Vitamin B3 ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule, Vitamin B3 conjugated to BSA....
Goat polyclonal to Glucose Dehydrogenase ( Abpromise for all tested applications). Antigen: Glucose Dehydrogenase (Bacillus species)...
Biology Products: