Navigation Links
A genetic 'gang of 4' drives spread of breast cancer

apillaries, they just got stuck there," said Massagué. "We concluded that metastatic cells use these same genes to loosen up cells in capillaries, so that the cells can penetrate the lung tissue to grow there.

"These findings provide a beautiful explanation for how the genes that we identified in breast cancer patients as being associated with lung metastasis manipulate blood vessels to give them an advantage both in the primary tumors and in the lung," he said.

Two drugs already on the market act directly on proteins produced by the genes Massagué’s group had been studying. Cetuximab is an antibody that blocks the action of epiregulin and is used to treat advanced colorectal cancer. Celecoxib is an inhibitor of COX2 that is used as an anti-inflammatory, and is being tested in clinical trials against many types of cancer. The researchers also tested whether cetuximab and celecoxib would work effectively in concert to reduce metastasis in mice.

"We found that the combination of these two inhibitory drugs was effective, even though the drugs individually were not very effective," said Massagué. "This really nailed the case that if we can inactivate these genes in concert, it will affect metastasis," he said.

Massagué said that while clinical trials of the drug combination are being discussed, "there are already treatments to diminish the chance of metastasis in breast cancer, so such trials would have to be designed very carefully to understand how and whether the new drug combination would be of additional benefit." In the article published in the Proceedings of the National Academy of Sciences, Massagué and his colleagues explored how the entire group of 18 genes, called the ‘lung metastasis gene-expression signature?(LMS) influenced both breast tumor growth and spread to the lungs. Co-authors on the paper were from the University of Chicago, The Netherlands Cancer Institute, Veridex L.L.C., The Cleveland Clinic and the Erasmus Me
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Scientists detect probable genetic cause of some Parkinsons disease cases
3. Mouse brain tumors mimic those in human genetic disorder
4. Scientists identify genetic pathways essential to RNA interference
5. Researchers trace evolution to relatively simple genetic changes
6. Key mechanism in genetic inheritance during cell division identified
7. Scientists identify genetic pathways essential to RNA interference
8. MUHC scientists describe genetic resistance to rampant virus
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Montreal researchers probe the genetic basis of memory
11. Biologists determine genetic blueprint of social amoeba
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: genetic gang drives spread breast cancer

(Date:7/2/2015)... Research and Markets( ... "Natural Language Processing Market by Type (Rule-Based, ... & Image Recognition) - Worldwide Forecast to 2020" ... key vendors occupying the market are 3M, Apple, ... NetBase Solutions, SAS Institute Inc., Verint Systems among ...
(Date:7/2/2015)... DUBLIN , June 25, 2015 ... the addition of the "Next Generation Biometrics Market ... to 2020" report to their offering. ... $24.4 Billion by 2020, at a CAGR of 17.9% ... is the leading application for the market. Safran ...
(Date:7/2/2015)... , July 2, 2015 Fingerprint ... FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor World Peace ... of FPC,s distributors in Asia . Deliveries ... The sensors will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of approximately 2,200 ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... 28, 2010Mary Ann Liebert, Inc. announces the release of ... systems neuroscience, Brain Connectivity . This timely new ... cutting-edge basic and clinical neuroscience research aimed at better ... and how these connections are altered by neurological disorders. ...
... release is available in Spanish . , ... multifiliis, also known as "Ich," a protozoan parasite that appears ... Department of Agriculture (USDA) scientist. Aquatic toxicologist ... sulfate as a method to control both Ich in catfish ...
... Emily Baechler Gillespie, PhD, at the University of Minnesota has ... could soon result in a test that quickly and easily ... flare is imminent. Such a test is critical ... person with systemic lupus is shifting from a cycle of ...
Cached Biology News:New Brain Connectivity journal captures latest advances in neuroscience research 2Helping fish get rid of the 'Ich' 2New clinical test to predict lupus flares moves closer to the market 2
(Date:7/6/2015)... ... July 06, 2015 , ... ... hosted their 2015 bi-annual Pain Management Medical Advisory Board meeting in Palm Springs, ... executive Research and Development team to discuss new clinical practice and research ideas. ...
(Date:7/6/2015)... 2015  Approximately 1% of the population inherits a ... These individuals are three times more likely to develop ... of the nation,s leading medical journals by researchers from ... Photo - http://photos.prnewswire.com/prnh/20150706/230685 ... roseola (also known as "sixth disease") and occasional seizures ...
(Date:7/6/2015)... NASHVILLE, Tenn. , July 6, 2015 ... has entered into a definitive agreement to ... technology and intervention platforms that combine data ... and reporting capabilities to achieve actionable insights ... acquisition will combine Altegra Health,s risk adjustment ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... molecular diagnostic tests are key drivers of the global molecular diagnostics market. BCC ... and the introduction of new companion diagnostic tests will increase demand for inexpensive ...
Breaking Biology Technology:Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 2Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 3Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Emdeon to Acquire Altegra Health 2Emdeon to Acquire Altegra Health 3Emdeon to Acquire Altegra Health 4Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3
... May 17 /PRNewswire-FirstCall/ - Aeterna Zentaris Inc. ( ... company specialized in oncology and endocrinology, today announced that ... product designation from the Committee for Orphan Medicinal Products ... AEZS-108 for the treatment of ovarian cancer. AEZS-108, the ...
... , May 17 Soligenix, Inc. (OTC Bulletin Board: SNGX) ... results for the first quarter of 2010. , ... Soligenix,s revenues for the first quarter of 2010 ... the first quarter of 2009. The decreased revenues were primarily a result ...
... Sigma- Aldrich announces the retirement of David Julien , President – ... on his current role in January 2009 .  He served as President ... to January 2009 and before that in a number of senior ... , , , ...
Cached Biology Technology:Aeterna Zentaris Receives Positive Opinion for Orphan Medicinal Product Designation for AEZS-108 for the Treatment of Ovarian Cancer from the Committee for Orphan Medicinal Products of the European Medicines Agency 2Aeterna Zentaris Receives Positive Opinion for Orphan Medicinal Product Designation for AEZS-108 for the Treatment of Ovarian Cancer from the Committee for Orphan Medicinal Products of the European Medicines Agency 3Soligenix Reports First Quarter 2010 Financial Results and Reviews Accomplishments 2Soligenix Reports First Quarter 2010 Financial Results and Reviews Accomplishments 3Soligenix Reports First Quarter 2010 Financial Results and Reviews Accomplishments 4Soligenix Reports First Quarter 2010 Financial Results and Reviews Accomplishments 5Sigma-Aldrich (Nasdaq: SIAL) Announces Executive Management Changes: Retirement of David Julien and Promotion of Joseph Porwoll 2
... Mass Spectrometry Applications ,In the age ... emerged as a powerful protein identification and ... is now an important intermediate step in ... to identification of specific proteins in the ...
... the only PCR system that ensures successful ... It provides accuracy, consistency, and dependability for ... property of the DNA templates. This system ... unique blend of thermostable enzymes that is ...
... Application: A cleaning agent ... plastic surfaces, countertops, and pipettors. ... at eliminating RNase contamination from ... enzymatic reactions. ,RNase Zap ...
A set of five proteins which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
Biology Products: