Navigation Links
A gene's first 'kiss' sets off that affair known as puberty

builds on the discovery made independently by both Harvard and French researchers that a gene called GPR54 is defective in children with a rare disorder that inhibits puberty's onset. To better understand what role GPR54 plays in the initiation of puberty, as well as learn about KiSS-1, which in earlier rodent studies had been identified as a molecule that activates a signal receptor of GPR54, the researchers looked to the nonhuman primate, the only animal with a reproductive system in common with the human's.

The onset of puberty becomes official when gonadotropin-releasing hormone (GnRH) is secreted and sets off a chain reaction of chemical messages. Inside the hypothalamus, nerve cells release GnRH in a 'round-the-clock,' pulsatile fashion. With each secretion, the pituitary gland is stimulated to secrete its own messengers, lutenizing hormone (LH) and follicle-stimulating hormone (FSH), directly into the circulation. In turn, these rising levels of LH and FSH cause the testes and ovaries to produce the sex hormones testosterone and estradiol, the culprits responsible for the physical changes and emotional baggage of male and female puberty, respectively.

"We now have very good evidence that the GPR54 gene and its switch, the kisspeptin protein molecule produced by KiSS-1, are key to the initiation of puberty, when GnRH is released," Dr. Plant said. "However, it's unlikely that they act alone. Other signaling systems, some of which have probably yet to be identified in humans, help control GnRH release in primates."

Besides learning that GPR54 and KiSS-1 are expressed inside the hypothalamus of primates at the time of puberty, the researchers also found that by giving animals kisspeptin they could, essentially wake up the reproductive hormones from their childhood hibernation. Within 30 minutes of kisspeptin being administered to male monkeys, LH, one of the hormones stimulated by GnRH secretion, was no longer dormant, with levels 25-times
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3

Related biology news :

1. Love at first smell
2. Worlds largest rainforest drying experiment completes first phase
3. PCRM develops worlds first cruelty-free insulin assay
4. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
5. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
6. DuPonts first biologically derived polymer receives global recognition
7. Anti cancer virotherapy well tolerated in first human administration, research finds
8. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
9. The first impact factor for PLoS Biology ?13.9
10. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
11. Researchers find first evidence of venom system in extinct mammal
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: gene first kiss sets off that affair known puberty

(Date:7/11/2014)... that under the normal circumstances, astrocytes participate ... neuronal environment, and exhibit therapeutic and repairing ... Previous studies have found that nerve cells ... induction have reduced viability, which produces influences ... Yuan, Kailuan General Hospital, Hebei United University, ...
(Date:7/11/2014)... study the proteins that let nerve cells send out ... upon a biological tactic that may offer a new ... safe and environmentally responsible way. , Their findingthat ... species and harmless for a closely related onesuggests that ... harming beneficial species like bees. A summary of the ...
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... SAN DIEGO, Calif. (March 9, 2009)The so-called "male ... canceris as effective as surgery in destroying diseased ... for patients of all risk levels and particularly ... released at the Society of Interventional Radiology,s 34th ...
... DIEGO, Calif. (March 9, 2009)A minimally invasive interventional ... relieve the pain of herniated diskswill become standard ... years, predict researchers at the Society of Interventional ... study, the interventional radiologists examined just how ozone ...
... (March 9, 2009)Osteoplastya highly effective minimally invasive ... metastatic bone disease by injecting bone cement ... pain relief, often presenting individuals who are ... effect," according to researchers at the Society ...
Cached Biology News:Freezing prostate cancer does a man's body good 2Freezing prostate cancer does a man's body good 3Freezing prostate cancer does a man's body good 4Freezing prostate cancer does a man's body good 5Oh, my aching back: Give me a shot of ozone 2Oh, my aching back: Give me a shot of ozone 3Metastatic bone disease patients can walk in Lazarus' footsteps 2Metastatic bone disease patients can walk in Lazarus' footsteps 3
(Date:7/11/2014)... -- Research and Markets  has announced the addition ... Industry Analysis, Size, Share, Growth, Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is a ... RNA) into cells. This technology helps the cells to ... metabolism by affecting the nuclear genes. The transfection technology ...
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its new ... GLOBAL MARKETS , the global market for digital polymerase ... 2013. This is estimated to grow to $490 billion ... (CAGR) of 28.6%. , New digital PCR technology has ... the broader PCR field. The opportunities presented by this ...
(Date:7/11/2014)... EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is ... . The new Wyss Center for Bio- ... Geneva , has named as its director one ... Donoghue , founder of Brown University,s Institute for Brain ...
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4
... allow AIDS viruses to escape detection by the immune ... after transmission to new hosts, scientists at the University ... Medicine. , ,The discovery may help researchers design vaccines ... the immune system to attack the virus where it's ...
... International, Inc. announced Tuesday Herbert Conrad as chairman of the ... on the board of directors. , , ... of Hoffmann-La Roche, Inc. He served as the chairman of ... 2003, and was a co-founder of Reliant Pharmaceuticals in addition ...
... Inc., , Wisconsin-based online clothing retailer, introduced Thursday an updated ... take the guesswork out of online shopping. , ,The new ... women find clothes that fit correctly by modeling garments virtually. ... model that closely resembles the customer. , ,Our customers tell ...
Cached Biology Technology:Studies Offer New Insight into HIV Vaccine Development 2
Cultrex 3D Culture Matrix Laminin I....
...
...
... Vector NTI Suite for Mac OS X ... for DNA and protein sequence analysis and ... OS X (Table 1). With Vector NTI ... transform share and publicize diverse types of ...
Biology Products: