Navigation Links
A gene's first 'kiss' sets off that affair known as puberty

builds on the discovery made independently by both Harvard and French researchers that a gene called GPR54 is defective in children with a rare disorder that inhibits puberty's onset. To better understand what role GPR54 plays in the initiation of puberty, as well as learn about KiSS-1, which in earlier rodent studies had been identified as a molecule that activates a signal receptor of GPR54, the researchers looked to the nonhuman primate, the only animal with a reproductive system in common with the human's.

The onset of puberty becomes official when gonadotropin-releasing hormone (GnRH) is secreted and sets off a chain reaction of chemical messages. Inside the hypothalamus, nerve cells release GnRH in a 'round-the-clock,' pulsatile fashion. With each secretion, the pituitary gland is stimulated to secrete its own messengers, lutenizing hormone (LH) and follicle-stimulating hormone (FSH), directly into the circulation. In turn, these rising levels of LH and FSH cause the testes and ovaries to produce the sex hormones testosterone and estradiol, the culprits responsible for the physical changes and emotional baggage of male and female puberty, respectively.

"We now have very good evidence that the GPR54 gene and its switch, the kisspeptin protein molecule produced by KiSS-1, are key to the initiation of puberty, when GnRH is released," Dr. Plant said. "However, it's unlikely that they act alone. Other signaling systems, some of which have probably yet to be identified in humans, help control GnRH release in primates."

Besides learning that GPR54 and KiSS-1 are expressed inside the hypothalamus of primates at the time of puberty, the researchers also found that by giving animals kisspeptin they could, essentially wake up the reproductive hormones from their childhood hibernation. Within 30 minutes of kisspeptin being administered to male monkeys, LH, one of the hormones stimulated by GnRH secretion, was no longer dormant, with levels 25-times
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3

Related biology news :

1. Love at first smell
2. Worlds largest rainforest drying experiment completes first phase
3. PCRM develops worlds first cruelty-free insulin assay
4. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
5. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
6. DuPonts first biologically derived polymer receives global recognition
7. Anti cancer virotherapy well tolerated in first human administration, research finds
8. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
9. The first impact factor for PLoS Biology ?13.9
10. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
11. Researchers find first evidence of venom system in extinct mammal
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: gene first kiss sets off that affair known puberty

(Date:10/22/2014)... , Oct. 20, 2014  Leading identity analyst ... time half of the world,s population will have a ... Europe . Asia ... the market accounting for more than 60% of all ... Acuity,s report  -- "The Global National eID ...
(Date:10/19/2014)... access in India over the last 30 years ... emissions growth during that time, according to a ... Climate Change ., "Energy access is fundamental to ... life, including education, communication, and health," says IIASA ... While increased energy access is widely agreed to ...
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Improved electricity access has little impact on climate change 2Whole-exome sequencing shows potential as diagnostic tool 2
... new study of the wandering albatross one of the largest ... are breeding earlier in the season compared with 30 years ago. ... Oikos , a British team of scientists describe how they studied ... of South Georgia. They have discovered that because some birds are ...
... BOSTON -- One of the biggest health problems facing children ... causing obesity and how the U.S. can tackle this problem ... Academic Societies (PAS) annual meeting in Boston. The symposium, ... and How Do We Get Out?" will take place on Monday, ...
... traditional rectangular patchwork of fields in this time series animation ... panhandle near the town of Dalhart, this transformation is due ... to fields. It was invented by farmer Frank Zybach in ... center of the field through a long pipe that rotates ...
Cached Biology News:Antarctic albatross displays shift in breeding habits 2What is really causing the child obesity epidemic? 2NASA's Landsat satellites see Texas crop circles 2
(Date:10/20/2014)... Convey Computer , the leader in ... State University won first place in the 2014 ... the team’s solution achieved the highest overall performance in ... place finisher. , Experts from all segments of the ... challenge, using a variety of design tools, hardware and ...
(Date:10/20/2014)... -- PureTech , a science and technology ... announced today the closing of a $55 million ... Perpetual, a $120 Billion group of funds. The ... pipeline forward and to advance new healthcare related ... to really go for the big ideas that ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, ... Geography Trend and Forecast (2011 - 2016)," analyzes ... and studies the major market drivers, restraints, and opportunities ... Asia. , The global chocolate market is expected to ... 2016 at an estimated CAGR of 2.7% from 2011 ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... How fast an intense laser pulse can change the ... Kiel University in the current edition of Nature ... Bauer, Dr. Kai Ronagel and Professor Lutz Kipp from ... colleagues from the University of Kaiserslautern and the University ...
... CHAMPAIGN, Ill. Technophiles who have been dreaming of ... may soon find their wish has been granted. ... ultra-low-power digital memory that is faster and uses 100 ... could give future portable devices much longer battery life ...
... 10, 2011 Dyadic International, Inc. (OTC Pink: DYAI), ... the year ended December 31, 2010. The financial information ... conjunction with the financial statements, footnotes and independent auditors, ... website at www.otcmarkets.com and on Dyadic,s website ...
Cached Biology Technology:New technology would dramatically extend battery life for mobile devices 2New technology would dramatically extend battery life for mobile devices 3Dyadic International Reports 2010 Fiscal Year Financial Results 2Dyadic International Reports 2010 Fiscal Year Financial Results 3Dyadic International Reports 2010 Fiscal Year Financial Results 4Dyadic International Reports 2010 Fiscal Year Financial Results 5Dyadic International Reports 2010 Fiscal Year Financial Results 6
... JNK (c-Jun NH2-terminal kinase) signal transduction ... MAP kinase pathways in mammals. JNK ... environmental stress, is associated with the ... is implicated in the immune response, ...
... knockdown of all human, mouse, and ... Genomewide, predesigned siRNAs for a ... , Ready-to-use, convenient matching solutions for ... Cost-effective RNAi and downstream analysis ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... Genetic Analysis System, which processes two 96-well plates ... adds a higher level of throughput to the ... of Beckman Coulters new GenomeLab family of products*, ... Biomek series liquid handers, for increased automation. ...
Biology Products: