Navigation Links
A 'dimmer switch' for genes

ual decline in DNA binding, gradually turning a gene off.

"One thing we didn't get was why Ets-1 worked differently before and after phosphorylation [the addition of phosphate]," says Pufall, "because as far as we could tell, the overall shape of the molecule didn't change."

"A protein molecule is not like a rock. It's more like Jell-O: it has structure, it has shape, but it jiggles," explains Graves. "We didn't discover jiggling, but we were able to determine that the amount of internal motion within a protein corresponds to the ability of a protein to do its work." Phosphorylation was found to decrease the internal motion of Ets-1, reducing its activity.

According to Pufall, "Ets-1 provides a remarkable illustration of how elegantly proteins are put together ?forming a distinct shape, but with the versatility to respond to the changing needs of the cell, however subtle."

The findings have long-term implications for the study of all proteins, because, according to Graves, any protein has the potential to be organized this way, with structured and unstructured regions that work together.


'"/>

Source:Huntsman Cancer Institute/University of Utah Health Sciences Center


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Molecular on/off switch controls immune defenses against viruses
3. Scientists find potential off-switch for HIV virus
4. Discovery of master switch for the communication process between chloroplast and nuclei of plants
5. Scientists document complex genomic events leading to the birth of new genes
6. Advances in the characterisation of the oyster mushroom genes
7. Compounds in plastic packaging act as environmental estrogens altering breast genes
8. Where bacteria get their genes
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. Exercise training in ordinary people affects the activity of 500 genes
11. Carnegie Mellon University research reveals how cells process large genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: dimmer switch for genes

(Date:7/30/2014)... JOSE, Calif. , July 30, 2014 /PRNewswire/ ... partnership with the United States Air Force Research ... proposed by Binghamton University ... human performance monitoring (HPM). The $425,000 project, with ... electronics packaging firm i3 Electronics, Inc. ( ...
(Date:7/29/2014)... the University of Bristol,s Nutrition and Behaviour Unit (NBU) ... account when planning meals. , The research, to be ... Behavior Conference (SSIB 2014) in Seattle, USA this week ... , The team was led by Professor Jeff Brunstrom, ... , As part of a Biotechnology and Biological Sciences ...
(Date:7/29/2014)... of science, researchers sometimes need to get back ... just that to study the impacts of the ... reef ecosystems at two remote locations in the ... tracking and computer simulation, McCauley, an assistant professor ... Biology, and his colleagues sought to understand whether ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3Underwater elephants 2Underwater elephants 3
... of food poisoning from the food chain is the aim ... Research Council (BBSRC) and the world-leading UK-based poultry breeding company ... cases of food poisoning a year in England and Wales ... 600 million a year. It is usually passed to humans ...
... Feb. 15, 2012 /PRNewswire-iReach/ -- The ... Groupware Collaborative, announced a new round of speakers and ... Forum , part of HIMSS12 on February 23, 2012 ... exhibition from the Healthcare Information and Management Systems Society ...
... airborne laser technology, satellite mapping, and ground-based plot surveys, ... high-resolution estimates of carbon stocks in remote and fragile ... to map carbon stocks in rugged geographic regions and ... employed to support conservation and climate-change mitigation under the ...
Cached Biology News:New research to help eliminate most common food poisoning bug 2Collaborative Health Consortium Announces eCollaboration Forum Final Agenda for HIMSS 2012 2Collaborative Health Consortium Announces eCollaboration Forum Final Agenda for HIMSS 2012 3 Super high-resolution carbon estimates for endangered Madagascar 2
(Date:7/30/2014)... NCERC at Southern Illinois University ... findings on corn stover pretreatment methods at a ... Washington, D.C. , “Arun’s selection for presentation ... testament to the success of our postdoctoral fellowship ... the foresight and vision of SIUE and the ...
(Date:7/30/2014)... 30, 2014 Immunology Summit-2014 ... Immunologists, Principle Investigators, scientists in the field, which ... Professor at Case Western Reserve University School of ... address on “The effects of recombinant human ... matrix metalloproteinase-9”. Arya Biragyn, a Senior investigator at ...
(Date:7/29/2014)... hurdled a number of significant technological challenges in ... technology originally created for the James Webb Space ... Harvey Moseley, a scientist at NASA,s Goddard Space ... electrostatically actuated microshutter arrays that is, those ... as functional as the current technology,s magnetically activated ...
(Date:7/29/2014)... be separated from its properties? On July 29, the ... of the first Cheshire Cat experiment, separating a neutron ... Orange, CA, and Vienna University of Technology. , Chesire ... thought Alice in Wonderland, "but a grin without a ... in my life!" Alice,s surprise stems from her experience ...
Breaking Biology Technology:NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4
... 2011 Zacharon Pharmaceuticals, Inc. today announced that ... collaboration with Pfizer Inc. to develop drugs for ... value of the collaboration to Zacharon is approximately ... development of compounds that may be discovered using ...
... as well as students working in micro-electromechanical systems ... developing common MEMS fabrication processes. A fundamental, comprehensive ... to be an important game-changing asset for the ... Handbook is an exhaustive design reference for researchers ...
... and DANVILLE, Pa., April 6, 2011 Definiens, the ... life sciences firm specializing in advanced cancer diagnostics, today ... tool for the diagnosis of cancer. Cernostics will apply ... tests for the treatment of a variety ...
Cached Biology Technology:Zacharon Pharmaceuticals Announces Research and Development Collaboration With Pfizer to Develop Drugs for Multiple Rare Disorders 2Zacharon Pharmaceuticals Announces Research and Development Collaboration With Pfizer to Develop Drugs for Multiple Rare Disorders 3MEMS Materials and Processes Handbook -- a comprehensive, practical resource 2Definiens and Cernostics Partner to Develop Multiplexed Cancer Diagnostic Tests 2Definiens and Cernostics Partner to Develop Multiplexed Cancer Diagnostic Tests 3