Navigation Links
A 'dimmer switch' for genes

ual decline in DNA binding, gradually turning a gene off.

"One thing we didn't get was why Ets-1 worked differently before and after phosphorylation [the addition of phosphate]," says Pufall, "because as far as we could tell, the overall shape of the molecule didn't change."

"A protein molecule is not like a rock. It's more like Jell-O: it has structure, it has shape, but it jiggles," explains Graves. "We didn't discover jiggling, but we were able to determine that the amount of internal motion within a protein corresponds to the ability of a protein to do its work." Phosphorylation was found to decrease the internal motion of Ets-1, reducing its activity.

According to Pufall, "Ets-1 provides a remarkable illustration of how elegantly proteins are put together ?forming a distinct shape, but with the versatility to respond to the changing needs of the cell, however subtle."

The findings have long-term implications for the study of all proteins, because, according to Graves, any protein has the potential to be organized this way, with structured and unstructured regions that work together.


'"/>

Source:Huntsman Cancer Institute/University of Utah Health Sciences Center


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Molecular on/off switch controls immune defenses against viruses
3. Scientists find potential off-switch for HIV virus
4. Discovery of master switch for the communication process between chloroplast and nuclei of plants
5. Scientists document complex genomic events leading to the birth of new genes
6. Advances in the characterisation of the oyster mushroom genes
7. Compounds in plastic packaging act as environmental estrogens altering breast genes
8. Where bacteria get their genes
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. Exercise training in ordinary people affects the activity of 500 genes
11. Carnegie Mellon University research reveals how cells process large genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: dimmer switch for genes

(Date:7/9/2014)... an associate professor of plant pathology and microbiology ... awarded the 2014 Alexopoulos Prize by the ... advancing the science of mycology the study of ... lichens, plant pathogens, and medically important fungi. , The ... early-career mycologist. Stajich received the award last month in ...
(Date:7/9/2014)... Research Centre (CNIO) have discovered that NANOG, an essential ... in stratified epitheliathose that form part of the epidermis ... vaginain adult organisms. According to the conclusions of the ... this factor could also play a role in the ... oesophagus and skin. , The pluripotency factor NANOG is ...
(Date:7/9/2014)... the puzzle behind nature,s ability to split the ... the development of artificial photosynthesis for clean, green ... international collaboration of scientists led by researchers with ... the SLAC National Accelerator Laboratory. , Working ... world,s most powerful x-ray laser, the researchers were ...
Breaking Biology News(10 mins):UC Riverside plant pathologist receives national recognition 2CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms 2Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3
... of Technology have created a new sampling device that ... pneumonia each year. Called PneumoniaCheck, the device created ... of diagnosing pneumonia, which is a major initiative of ... Pneumonia, an inflammation of the lungs, kills about ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
... 18, 2011) -- A University of Arizona College of ... robots for planetary exploration will be featured in a ... "WaveLengths." The robots will be featured on the ... MST on public television KUAT Channel 6. "WaveLengths" is ...
Cached Biology News:A better way to diagnose pneumonia 2A better way to diagnose pneumonia 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2Planetary exploration robots to be featured on science program 'WaveLengths' 2
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... Wis. - Building the Merge Healthcare ... explains, will mean offshoring 150 jobs to a "more ... reduce 28 percent of the financially troubled medical imaging ... Japan to regain the competitive edge marks the centerpiece ...
... people, a natural biological response to the phrase securities law ... the outside of the cornea wall, coupled with a dull ... my best to stick to the essentials. As a result, ... company is raising capital, it is important to contact an ...
... Wisconsin organizers of Make Mine a $Million ... May as Wisconsin does its part to take one ... , ,Although the date of the awards program has ... including Make Mine a $Million members - soon will ...
Cached Biology Technology:Merge offshoring jobs to "more cost-effective" workforce 2Merge offshoring jobs to "more cost-effective" workforce 3Securities compliance is part of raising capital 2Securities compliance is part of raising capital 3Securities compliance is part of raising capital 4Make Mine a $Million shoots for May program 2Make Mine a $Million shoots for May program 3