Navigation Links
A 'dimmer switch' for genes

ual decline in DNA binding, gradually turning a gene off.

"One thing we didn't get was why Ets-1 worked differently before and after phosphorylation [the addition of phosphate]," says Pufall, "because as far as we could tell, the overall shape of the molecule didn't change."

"A protein molecule is not like a rock. It's more like Jell-O: it has structure, it has shape, but it jiggles," explains Graves. "We didn't discover jiggling, but we were able to determine that the amount of internal motion within a protein corresponds to the ability of a protein to do its work." Phosphorylation was found to decrease the internal motion of Ets-1, reducing its activity.

According to Pufall, "Ets-1 provides a remarkable illustration of how elegantly proteins are put together ?forming a distinct shape, but with the versatility to respond to the changing needs of the cell, however subtle."

The findings have long-term implications for the study of all proteins, because, according to Graves, any protein has the potential to be organized this way, with structured and unstructured regions that work together.


'"/>

Source:Huntsman Cancer Institute/University of Utah Health Sciences Center


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Molecular on/off switch controls immune defenses against viruses
3. Scientists find potential off-switch for HIV virus
4. Discovery of master switch for the communication process between chloroplast and nuclei of plants
5. Scientists document complex genomic events leading to the birth of new genes
6. Advances in the characterisation of the oyster mushroom genes
7. Compounds in plastic packaging act as environmental estrogens altering breast genes
8. Where bacteria get their genes
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. Exercise training in ordinary people affects the activity of 500 genes
11. Carnegie Mellon University research reveals how cells process large genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: dimmer switch for genes

(Date:8/28/2014)... the University of Minnesota have developed an animal research ... for muscle regeneration research as well as studies of ... research is published in the current edition of the ... treatment for FSHD, which is thought by many to ... is an unusual genetic disorder because, unlike most genetic ...
(Date:8/28/2014)... Athens, Ga. The support of peer groups ... effective breastfeeding programs, according to recent University of ... mothers in the Athens-Clarke County area determined that ... the outcomes of mothers of infants. , "Mothers ... be successful at breastfeeding," said study co-author Alex ...
(Date:8/28/2014)... Advocate and Senior Staff Attorney at the Electronic Frontier ... of biometric and mobile commerce experts set to speak ... Tampa, Florida on September 15, ... Rahman, Director, Technology and Strategy at Samsung, and Philippe de ... this year,s event is Mobility at the Crossroads of ...
Breaking Biology News(10 mins):UMN researchers find animal model for understudied type of muscular dystrophy 2Breastfeeding study shows need for effective peer counseling programs 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... Ore. -- (May 9, 2011) -- High in the sky, ... airborne pollutants such as sulfur dioxide into reactive aqueous particulates. ... emerging research from the University of Oregon provides evidence that ... a pollutant of volcanic gasses and many combustion processes -- ...
... A collaboration between BBSRC, EPSRC and industry has today ... ways of extracting valuable chemicals from the co-products of ... biofuels produces low-value derivatives that are often sold as ... to find ways of processing these by-products to yield ...
... has shown promising results for treating coeliac disease in a ... Phase II trials within the next year. The Phase ... and bioactivity of the vaccine Nexvax2, which has been developed ... by an immune reaction to the gluten protein found in ...
Cached Biology News:Researchers get new view of how water and sulfur dioxide mix 2Public and private sectors unite to make more of brewing by-products 2Celiac disease vaccine shows promising results in Phase I trial 2
(Date:8/28/2014)... 2014 Whitehouse Laboratories is excited to ... with PTI Inspection Systems that will enable ... the art leak testing method development and validation programs ... available. As part of this agreement, Whitehouse Labs has ... Detection Instrument developed and manufactured by PTI. The ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
(Date:8/27/2014)... In 2013, Lawrence Livermore National ... Security LLC (LLNS), was awarded more than ... laser system for the European Union's Extreme Light ... the Czech Republic. , When commissioned to its ... " High repetition-rate Advanced Petawatt Laser System " ...
(Date:8/27/2014)... , Aug. 27, 2014   MSC , ... patient safety, today announced the appointment of Mary ... With 28 years of experience preparing companies for ... 2013 as Executive Vice President of Corporate Development and ... performance improvement business , as well as corporate strategy ...
Breaking Biology Technology:Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3MSC names Mary Beth Loesch President and CEO 2
... Ontario and WAKE FOREST, N.C., Feb. 23, 2012 ... ( www.tersusenv.com ) announced today the signing of ... Under the terms of the agreement, Tersus Environmental ... – KB-1® and KB-1® Plus – as well ...
... PRA, a leading Clinical Research Organization, continues our expansion ... of an office in Singapore. The office will serve ... strengthening the quality and timeliness of our deliverables to ... the heart of the city-state, will provide monitoring, project ...
... PARK, Calif., Feb. 23, 2012 Telome Health, Inc.™, ... telomere biology in human health, has announced that co-founder and ... Year by Silicon Valley Business Journal. ... award, especially coming from the heart of innovation, Silicon Valley, ...
Cached Biology Technology:PRA Opens Office in Singapore 2Telome Health Co-founder and Nobel Laureate Elizabeth Blackburn Awarded Innovator of the Year 2
... The H2OBIT is a fully licensed, high throughput, ... processing of up to 24 microplates. This equates ... plates. ,A robotic arm rapidly transfers a ... in temperature ramping times that are considerably faster ...
... Dideoxycytidine Dideoxycytidine is a cytidine analog that ... retroviral activity. Immunogen: Chemical / ... The specificity of the ddC antiserum was ... of ddC to moles of ddC analog at ...
... series of Class II Biological Safety ... certification to the world's highest safety ... the cabinets cannot be adjusted out ... low noise and arm rest ensure ...
... HM-4000 Multidizer is designed with a variety ... rotating - all in one unit. Shake, ... independently operating compartments allow for hybridization and ... motion , The upper chamber uses ...
Biology Products: