Navigation Links
A 'dimmer switch' for genes

A protein that was thought to simply turn genes on and off now looks to be more like a cellular "dimmer switch," researchers from Huntsman Cancer Institute at the University of Utah, report in the July 1, 2005, issue of the journal Science.

The scientists showed for the first time that when certain parts of a protein molecule are modified ?flexible, randomly structured regions believed to be only minor players in the protein world ?they become important in turning genes on and off, but in a way that resembles a dimmer switch rather than an on-off switch.

Genes carry the code that produces proteins to carry out almost all functions in a living organism. But some of these proteins also help control when and where genes do their jobs. The new study deals with how one such protein, named Ets-1, turns genes on or off.

Huntsman Cancer Institute scientists, led by Barbara Graves, Ph.D., professor and chair of the Department of Oncological Sciences at the University of Utah School of Medicine, and doctoral student Miles Pufall, studied Ets-1, a protein known as a transcription factor that helps read genetic information. This factor serves as a cell's librarian, helping find the right genetic instructions.

How much information the librarian provides, and how accurate that information is, must be tightly controlled. Without the right information, cells can't behave properly, and may, as in the case of cancer, grow out of control. The connection between factors such as Ets-1 and a number of cancers prompted the study of how it works.

One way proteins are controlled occurs after a cell creates a protein. Graves illustrates this process by comparing protein structure with beads on a string. "After the protein is made, it can acquire what we call post-translational modifications, which are like decorations on a beaded necklace. In this analogy, one person creates a necklace using similar beads and then a committee comes along and decorates i
'"/>

Source:Huntsman Cancer Institute/University of Utah Health Sciences Center


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Molecular on/off switch controls immune defenses against viruses
3. Scientists find potential off-switch for HIV virus
4. Discovery of master switch for the communication process between chloroplast and nuclei of plants
5. Scientists document complex genomic events leading to the birth of new genes
6. Advances in the characterisation of the oyster mushroom genes
7. Compounds in plastic packaging act as environmental estrogens altering breast genes
8. Where bacteria get their genes
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. Exercise training in ordinary people affects the activity of 500 genes
11. Carnegie Mellon University research reveals how cells process large genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: dimmer switch for genes

(Date:9/11/2014)... a sudden, catastrophic event plunged much of the Earth ... This drastic climate changethe Younger Dryascoincided with the extinction ... the mastodon, and resulted in major declines in prehistoric ... , With limited evidence, several rival theories have been ... as a collapse of the North American ice sheets, ...
(Date:9/11/2014)... than 150 species of beetles in the genus Calathus ... mountains of the Ethiopian Highlands. Now scientists have found two ... carballalae and have described them in Annals ... juan is named for Juan Novoa, the son of ... various beetle-collecting expeditions. Adults are black and shiny, and are ...
(Date:9/11/2014)... MISSOULA From antlers to horns, humans have ... themselves with their natural-born weapons. But until now, ... perform better at the animals, own style of ... of another species. Researchers at the University of ... adapted to meet their own functional demands of ...
Breaking Biology News(10 mins):Microscopic diamonds suggest cosmic impact responsible for major period of climate change 2UM research reveals secrets of animal weapons 2
... July 4, 2011 For several years, scientists have been ... disease type 2D: how can different types of mutations, spread ... a team of scientists at The Scripps Research Institute may ... which is mutated in individuals with the disease, the team ...
... which affects one in every 3,000 people. The severity ... patches on the skin, through small tumors under the ... the nerve sheath. New research published in BioMed Central,s ... a simple blood test for the protein melanoma-inhibitory activity ...
... A genome-wide study by researchers at the RIKEN Center ... Hospital has identified a genetic variant associated with the ... carriers. The findings are based on a study of ... Nature Genetics . Hepatocellular carcinoma (HCC), the most ...
Cached Biology News:Scripps Research scientists solve mystery of nerve disease genes 2Scripps Research scientists solve mystery of nerve disease genes 3Scripps Research scientists solve mystery of nerve disease genes 4
(Date:9/14/2014)... MD (PRWEB) September 15, 2014 ... be held on Tuesday, October 21, 2014, from 12:00 ... overview of the program’s innovative curriculum and practice-oriented instruction, ... a graduate degree can help advance their career in ... RSVP online . , About UMBC’s Biotechnology ...
(Date:9/14/2014)... regulate protein functions in a wide variety of ways, ... a protein can take on another form and perform ... that fold wrongly can cause serious diseases such as ... also have a tendency to "infect" other molecules of ... fibrils or plaques. These amyloids can damage cells and ...
(Date:9/14/2014)... ingenious when it comes to survival strategies. They often ... environment, for example during treatment with antibiotics. A biofilm ... protective slime capsule consisting of sugar chains and "curli". ... for the first time created a detailed three-dimensional image ... cross the bacterial cell wall, a crucial step in ...
(Date:9/13/2014)... Phoenixville, PA (PRWEB) September 13, 2014 ... medical device innovations, is proud to announce the successful ... Health Network bariatric surgeons Leonardo Claros, MD, FACS, FAMBS, ... ViSiGi 3D™ Sleeve Gastrectomy Calibration System. , This ... a postgraduate course of more than four hundred surgeons ...
Breaking Biology Technology:UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2Measuring modified protein structures 2Measuring modified protein structures 3New insights in survival strategies of bacteria 2Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2
... Genome Sciences,Inc. (Nasdaq: HGSI ) announced today ... Biotechnology & Medical Device Conference will,be webcast and ... (Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO ), A member ... present,an overview of the company on Wednesday, February ...
... Plant First to be Awarded Shingo Prize Outside of North ... ... Baxter International Inc.,s,(NYSE: BAX ) manufacturing facility in Cartago, Costa Rica ... the first to be awarded the Shingo Prize outside North America,-- is ...
... recent study published this month,in the journal, Pediatrics, suggests ... linked to the presence of phthalates in babies. Phthalates,are ... variety of everyday,products. They are used primarily as plasticizers, ... be used to stabilize and make,fragrances work properly. The ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2Statement by John Bailey, Chief Scientist: The Personal Care Products Council Response to Study on Phthalate Exposure in Baby Care Products 2
... Spin Kit is an advanced system for isolating DNA ... can be used directly for any downstream application. ... ready to use in 56 minutes Low melting ... TAE and TBE gels No specialised equipment required ...
... incubators with rotators. Graduated, 35 mm ... plug-seal screw-cap with O-ring for a ... to accept different size hybridization membranes. ... separately. • Comp Dim: tube L ...
... The SpinPrep Gel DNA Kit enables efficient extraction of ... in size from agarose gels. The procedure uses GelMelt ... of the DNA to a silica membrane in a ... DNA is eluted in low-salt buffer. Each spin column ...
... is ideal for the ... (1D electrophoresis, 2D electrophoresis, ... Pharmacokinetics & Toxicology (whole ... chromatography); Physical and Material ...
Biology Products: