Navigation Links
A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

ccine is an RNA virus called VEE, for Venezuelan equine encephalitis, which in its natural form can cause disease in horses. Researchers at AlphaVax, Inc., a privately held biotechnology company in Research Triangle Park, N.C., have deleted certain genes from the VEE virus, thereby making it impossible for the vector version of virus to reproduce itself, but still allowing the vector to express the target protein. For this study, the researchers inserted the gene for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as “VRP-neu.?When these non-propagating particles are injected into an animal, the vector directs the animal’s cells to make thousands of copies of the HER2/neu growth protein, says Lachman. In addition, the VRP-neu preferentially homes to specialized immune system cells known as dendritic cells, and infects them. Inside, VRP-neu produces high levels of the HER2/neu protein, which the dendritic cells then display on the outside of their cell surface. This is, in fact, a neat trick, says Lachman, because the function of dendritic cells is to flag the immune system by presenting “antigen,?or pieces of a foreign invader, to activate an immune response. “So now, the same immune system cells that rev up the immune system are displaying HER2/neu proteins as antigens,?Lachman says. What results is a strong response against HER2/neu that incorporates all three arms of the immune system ¯ B cell, T cell and natural killer cells ¯ and which creates a long-lasting immune memory primed to attack breast cancer cells that are studded with HER2/neu proteins, he says. In the experiments, three groups of seven mice were treated with three injections of a vaccine. The “control?arm received a VRP vaccine that contained an influenza protein, and the other two groups received one of two different doses of the VRP-neu vaccine. Researchers then implanted a HER2/neu-positive tumor into mam
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Lipids get new comprehensive classification system
2. NIH launches comprehensive effort to explore cancer genomics
3. Amgen introduces comprehensive financial assistance programs for cancer patients
4. RNA map provides first comprehensive understanding of alternative splicing
5. LIAI completes worlds most comprehensive analysis on influenza virus data
6. Poplar trees redirect resources in response to simulated attack
7. Scientists solve structure of key protein in innate immune response
8. Harmful chemicals may reprogram gene response to estrogen
9. Mouse with designer liver has enhanced glucose tolerance, insulin response
10. A protein in the eye may prevent immune response and protect eyes from disease
11. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
Post Your Comments:
(Date:7/28/2014)... team of researchers led by the University of Arizona ... The genetic information will enhance scientists, and agriculturalists, understanding ... as enable the development of new rice varieties that ... to help solve global hunger challenges. , The paper, ... ) and evidence for independent domestication," was published online ...
(Date:7/28/2014)... and organic compounds in hydrothermal environments are critical components ... for the deep biosphere, and may have implications for ... about how minerals influence organic reactions. A team ... a common mineral acts as a catalysts for specific ... solvents or expensive reagents. , At the heart of ...
(Date:7/28/2014)... Researchers at Yale School of Medicine have pinpointed a mechanism ... glucose levels in the blood, linking it to both type ... the July 28 issue of Proceedings of the National ... prolyl endopeptidase enzyme located in a part of the ... of steps in motion that control glucose levels in the ...
Breaking Biology News(10 mins):Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Glucose 'control switch' in the brain key to both types of diabetes 2
... Bird species in rainforest fragments in Brazil that were ... according to research results published today in the journal ... the birds had gone extinct. The research was ... in cooperation with Projeto Dinmica Biolgica de Fragmentos Florestais, ...
... graduate students have invented a device to reduce the risk ... patients who need blood-cleansing dialysis because of kidney failure. ... a patient,s leg, would give a technician easy access to ... at the beginning and end of a dialysis procedure. ...
... This release is available in Spanish . ... environment if they are subjected to microencapsulation, due to the ... substance. This is the conclusion of chemist Ms Mariluz Alonso ... Country (UPV/EHU). In this research, she chose a number of ...
Cached Biology News:Tropical birds return to harvested rainforest areas in Brazil 2Tropical birds return to harvested rainforest areas in Brazil 3Student team invents device to cut dialysis risk 2Biocides that attack only insects 2Biocides that attack only insects 3
(Date:7/28/2014)... The global market for biotechnology is ... to a new study by Grand View Research, Inc. ... effective vaccines and drugs in an attempt to improve ... expected to drive market demand over the next six ... via the use of genetically engineered seeds is expected ...
(Date:7/28/2014)... , July 28, 2014 Research and ... Particle Size Analysis Market 2014-2018" report to their offering. ... Particle size analysis is a technique used to determine the ... or liquid. It is crucial to analyze the size of ... Therefore, particle size analysis is performed to determine the behavior ...
(Date:7/25/2014)... 26, 2014 "Ischemic Stroke and ... provides data on the Ischemic Stroke and Cerebral ... information and data relating to the clinical trials ... full global Ischemic Stroke Research Report 2014 at: ... of the trial numbers and their recruitment status ...
(Date:7/25/2014)... by researchers from the University of Leicester has ... unlocking the potential to create new materials using ... been published in the prestigious academic journal ... technique to examine in rich detail the structure ... containing an acetylene molecule and a single helium ...
Breaking Biology Technology:Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4Global Particle Size Analysis Market 2014-2018 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... ROG; OTCQX: RHHBY) announced today that the cobas ® TaqScreen ... system is now available with the CE Mark. It is the ... of parvovirus B19 (B19V) and hepatitis A virus (HAV) in one ... (NAT) test which simultaneously quantifies B19V genotypes 1, 2 and 3 ...
... Oct. 1 Biotech posted its strongest monthly and quarterly ... strongest September rally for equities in more than 70 years. ... month and 13 percent in the third quarter. The Dow ... biggest appreciation during what historically has been a bad month ...
... recently completed a pilot-scale study wherein Kibow(R) Biotics were ... USA, Canada, Argentina and Nigeria. The positive outcome from ... issue of the peer-reviewed "Advances in Therapy" journal. This ... Promoting Health Kidney Function in Patients with Chronic Kidney ...
Cached Biology Technology:First Duplex Test for Parvovirus B19 and Hepatitis A Virus Increases Safety of Human Plasma and Plasma Products 2First Duplex Test for Parvovirus B19 and Hepatitis A Virus Increases Safety of Human Plasma and Plasma Products 3Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 2Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 3Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 4Kibow Biotech Releases Results of Pilot Scale Study of Its Probiotic Formulation for Kidney Health 2Kibow Biotech Releases Results of Pilot Scale Study of Its Probiotic Formulation for Kidney Health 3
Form: Ready to use Applications: ELISA...
Form: Ready to use Applications: ELISA...
ANTI S. GROUP AG:H...
Recorder REC-111 single-channel, 1. Category: Chromatography Systems & Accessories, Systems....
Biology Products: