Navigation Links
A clue from macaques yields evidence for impaired retroviral defense genes in humans

Researchers Harmit Malik and Michael Emerman and colleagues at the Fred Hutchinson Cancer Research Center have found that a surprisingly large fraction of humans may be impaired in the function of a recently discovered arm of the body's defense against invading retroviruses such as HIV.

One of the key components of this "intrinsic immunity" is encoded by the TRIM5 gene. This gene was discovered because the version of TRIM5 possessed by rhesus macaques allows them to resist HIV infection, whereas the human version does not. Instead, the human version appears to respond to evolutionarily older viruses that are related to now-extinct viruses that are resident in the human genome.

Previous studies had suggested that relatively few evolutionary changes in the TRIM5 protein were responsible for this difference in battling retroviral infection. This prompted the Malik and Emerman groups to screen human populations for slightly altered versions of TRIM5 that might be able to resist HIV infection.

Unexpectedly, the researchers found a single mutation in TRIM5 that impairs its ability to defend against retroviruses. This mutation occurs at a very high frequency in some ethnic groups, leading the authors to conclude that past periods in human history corresponding to relatively low levels of retroviral infections may have allowed impaired versions of retroviral defense genes--such as the hobbled version of TRIM5--to arise and thrive. As a consequence, the abundance of this impaired gene may have deleterious effects on the ability of present-day humans to ward off infections by both old and new retroviruses.


'"/>

Source:Cell Press


Page: 1

Related biology news :

1. Genome-wide mouse study yields link to human leukemia
2. Marine sponge yields nanoscale secrets
3. Small worm yields big clue on muscle receptor action
4. Organic farms produce same yields as conventional farms
5. GM crop that holds on to its seeds offers higher yields
6. Seaweed yields new compounds with pharmaceutical potential
7. Computer-chemistry yields new insight into a puzzle of cell division
8. Infection alarm yields clues to immune system behavior
9. BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins
10. Food-crop yields in future greenhouse-gas conditions lower than expected
11. More than drought affecting wheat yields
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... NEWARK, Calif. , Jan. 5, 2017  Delta ... introduced its iris scanning technology for automotive at CESĀ® ... GNTX ) to demonstrate the use of ... to identify and authenticate the driver in a car, ... automobiles during the driving experience. Delta ID ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
(Date:12/22/2016)... , Dec. 20, 2016  As part of its ... the leading personal genetics company, recently released its latest children,s ... . The book focuses on the topics of inheritance and ... Science Standards (NGSS) taught in elementary school classrooms in the ... a series by illustrator Ariana Killoran , whose previous ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... 2017 Ginkgo Bioworks, the organism company, ... in the synthesis and assembly of DNA. The ... pathway-length synthetic DNA into Ginkgo,s automated organism engineering ... construction of new organism designs for application across ... was founded to significantly increase the world,s capacity ...
(Date:1/19/2017)... Research and Markets has announced the addition ... Type, Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" ... ... is projected to reach $15,737 million by 2022 from $6,521 in ... Omic technologies segment accounted for more than half ...
(Date:1/19/2017)... -- WuXi AppTec, a leading global pharmaceutical, biotechnology ... today announced that it has acquired HD Biosciences ... contract research organization (CRO). After completion of acquisition, ... WuXi, and will continue to focus on growing ... acquisition will further strengthen WuXi,s R&D capability from ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... of product vigilance software to leading biopharmaceutical and medical device manufacturers and regulators, ... a fully 21 CFR Part 11-compliant email client designed to provide product vigilance ...
Breaking Biology Technology: