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A catalogue of proteins

tists took the protein complex apart, these proteins were used as markers. Proteins which appear together with these marker-proteins could now also be assigned their proper place in the inventory. This method, called protein correlation profiling, was developed by Matthias Mann and his colleagues, and has previously been successfully used to determine the composition of single cell-organelle protein.

After the individual "compartments" for the proteins were identified, the scientists compared corresponding protein sets of individual cell organelles. Among the 1400 different proteins that can be clearly mapped onto individual cell organs, around 40% of them also appear in other cell organs. This result can be compared with studies on yeast cells. Their proteins have stayed "true" to their cell organelles over the course of evolution. Their localisation has apparently remained stable over almost a billion years, as simple organisms evolved all the way to mammals.

These results are a milestone in cell biology. Matthias Mann says, "for the first time, we are able to determine where exactly in the cell large numbers of proteins belong. It allows a new understanding of their function and interaction with other cellular proteins and cell organelles." The researchers hope that protein correlation profiling will allow them to determine which proteins participate in failures of regulation. This could contribute to research into diseases which occur when communication between cells is disturbed.


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Source:Max-Planck-Gesellschaft


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