Navigation Links
A bacterial genome reveals new targets to combat infectious disease

More than a billion people are at risk for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wolbachia bacterium is so crucial to its host nematode that apparently eradicating it with antibiotics severely compromises the nematode's ability to complete its life cycle within its human host. Thus, understanding the details of this relationship may help identify new strategies for controlling diseases caused by filarial nematodes. In a new study published in the freely-available online journal PLoS Biology, Barton Slatko and colleagues present the complete DNA sequence of the Wolbachia pipientis strain within Brugia malayi, a parasitic nematode responsible for lymphatic filariasis.

This Wolbachia genome is small, only about a million base pairs, and many metabolically critical genes have degraded through mutation to the point of uselessness. This phenomenon, called reductive evolution, is typical of long-term symbioses, as the two partners increasingly complement one another's biochemical activities.

Slatko and colleagues enumerate a variety of pathways that have either been degraded or preserved, and highlight patterns in the genome structure through comparisons with other bacteria. For example, Wolbachia can manufacture some essential metabolic coenzymes, which do not appear to be made by its host. Conversely, it cannot synthesize amino acids and a variety of other vitamins and cofactors, and probably depends on the nematode to supply them.

One discovery of possible significance is the presence in the bacterium of the synthetic pathway for heme - the oxygen-carrying iron component of hemoglobin. The nematode may require heme for synthesis of devel
'"/>

Source:PLoS Biology


Page: 1 2

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Scientists discover that host cell lipids facilitate bacterial movement
4. Protein prevents detrimental immune effects of bacterial sepsis
5. Researchers develop new method for facile identification of proteins in bacterial cells
6. A virus-like hitchhiker may trigger bacterial meningitis
7. Using the genomic shortcut to predict bacterial behavior
8. Eliminating bacterial infections out of thin air
9. Student scientists create living bacterial photographs
10. Researchers identify molecular anchor that allows bacterial invasion of central nervous system
11. Scientists determine structure of enzyme that disrupts bacterial virulence
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: bacterial genome reveals new targets combat infectious disease

(Date:9/30/2014)... (PCE) in drinking water may increase the risk ... new study led by a Boston University School ... in the journal Environmental Health , compared ... 1,766 women in Cape Cod, Ma., where water ... early 1980s by the installation of vinyl-lined asbestos ...
(Date:9/30/2014)... FRANKFURT. Truffles, along ... world. Because they grow underground, people use trained dogs or ... is not only of interest to gourmets. A group of ... University Frankfurt have discovered that the smell of white truffles ... truffle fruiting bodies. , White truffles from the Piedmont region ...
(Date:9/30/2014)... Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich report that ... cells more sensitive to chemotherapeutic drugs. They have ... a new target for anti-tumor agents. , ... Professor Stephan Sieber of the Technische Universitt Mnchen ... a potential new weapon in the fight against ...
Breaking Biology News(10 mins):Contaminated water linked to pregnancy complications, BU study finds 2On the trail of the truffle flavor 2Cancer therapy: Driving cancer cells to suicide 2
... minds about the head size of an ancient human ancestor, ... may have been. Found in Gona, Ethiopia, not far from ... of the famed Australopithecus afarensi "Lucy," the pelvis indicates that ... ago, had a larger birth canal than originally suspected and ...
... , 2008 Arbor Vita Corporation (AVC), a ... its rapid, point-of-care prototype HPV test with a high ... for use throughout the developing world, this diagnostic test ... presentation, "Development of a Rapid Diagnostic Test for Cervical ...
... to make cancer treatment safer A new piece ... (NPL) today will help improve the success rates of ... (linac) will help ensure patients are treated with accurate ... using ionising radiation such as high-energy X-rays or electron ...
Cached Biology News:Arbor Vita presents new data on cancer diagnostic at EUrogin 2NPL unveils new equipment to make cancer treatment safer 2
(Date:10/1/2014)...  Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" or the ... of high pressure-based sample preparation systems to the life ... to present at the 2 nd  Global Life ... The Conference will take place at the Warsaw Stock ... Schumacher , President and CEO of PBI, will present ...
(Date:10/1/2014)... City, CA (PRWEB) October 01, 2014 As ... it leaves no room for doubt that this century would ... innovations in the field of medicine science. The fact that ... problems is not unknown to the scientific community. Almost half ... pollution and therefore can be prevented with medical care and ...
(Date:10/1/2014)... 2014 New applications of structures and ... evolved in nature over millennia are featured in a ... for applications in biophotonics in the October issue of ... is published by SPIE, the international society for optics ... the peer-reviewed articles are accessible via open access. , ...
(Date:10/1/2014)... 01, 2014 The U.S. Department of ... Illinois University Edwardsville as part of the Trade Adjustment ... funding is co-administered by the Department of Labor and ... of Labor Thomas E. Perez and Secretary of Education ... job-driven training grants to nearly 270 colleges across the ...
Breaking Biology Technology:Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 2Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 3Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 4Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4
... WASHINGTON, Oct. 5 The Coalition for a,Competitive ... the Food and Drug Administration,s announcement regarding its,"Generic ... consumers, employers, insurers, and policymakers grappling with,how to ... that FDA,and Congress continue to focus on ways ...
... Lexicon,Pharmaceuticals, Inc. (Nasdaq: LXRX ) today announced that ... officer, will present,at the BIO InvestorForum at The Palace ... at 11:00 a.m. Pacific Time. A live webcast ... at http://www.lexpharma.com . An archived version of the,webcast ...
... Pharmasset, Inc.,(Nasdaq: VRUS ) has entered into ... Subject to certain terms and conditions of,the agreement, Horizon ... At its option, Pharmasset may receive a second loan ... loan of $10 million by November 30, 2008,provided conditions ...
Cached Biology Technology:CCPM Issues Statement on FDA's GIVE Initiative 2Lexicon Pharmaceuticals to Present at Bio InvestorForum 2Pharmasset Accesses up to $30 Million of Working Capital 2Pharmasset Accesses up to $30 Million of Working Capital 3
... you reduce the chance of error. Thats ... Developed using Beckman Coulters extensive experience in ... technology, the CEQ 8000 is a fully ... fills the capillary array with a patented ...
... Chemicon Detergent-OUT Kit is a simple high ... solutions. Removes detergents without significant dilution ... protein solution on the Detergent-OUT Spin column ... columns are suitable for removing detergent from ...
... The standard electrophoresis hood is ... documentation systems. Placed on the ... in place and provides a ... on the lab bench. This ...
... SDS Kit is a simple high performance ... Removes detergents without significant dilution of ... solution on the Detergent-OUT Spin column and ... columns are suitable for removing detergent from ...
Biology Products: