Navigation Links
A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

es. Furthermore, in the absence of IL-25, mice developed a destructive inflammatory response similar to that observed in models of inflammatory bowel disease.

These results also support the notion that the immune response that causes allergies and asthma is an evolutionary hangover resulting from mankind's historical fight with parasitic worm infections. That is, a type 2 response that was once useful in fighting worm infections has now become a dangerous menace, causing inflammatory responses to commonly encountered environmental antigens. About 30 percent of Americans suffer from the negative affects of type 2 inflammation: asthma and allergies. These conditions result from an inflammatory response to factors encountered in the environment, whether they are industrial air pollutants or molecules of peanut oil.

"It is possible that for most of human history, cytokines like IL-25 have promoted type 2 T helper cells that fight infection with intestinal parasites like Trichuris, " said Colby Zaph, a co-author and Irvington Research Fellow at Penn. "In industrialized countries, where worm infections are now rare, this redundant type 2 response is associated with diseases like asthma. "Identifying a role for IL-25 in this type of response may offer an exciting new avenue for treating diseases associated with dysregulated inflammatory responses," Zaph said.


'"/>

Source:University of Pennsylvania


Page: 1 2

Related biology news :

1. Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods
2. Texas scientists discover how a hepatitis C protein promotes liver cancer
3. Meth promotes spread of virus in HIV-infected users
4. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
5. Salk scientists hammer out a pathway that promotes muscle cell survival in mice
6. Scientists narrow the time limits for the human and chimpanzee split
7. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
8. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
9. Protein finding could lead to treatment for inflammatory diseases
10. Anti-inflammatory drugs potentially deadly side effect found to be rare
11. Selectively blocking inflammatory signals may protect mice from MS
Post Your Comments:
(Date:8/12/2015)... 12, 2015 As the digital ... innovation and advanced biometrics technology is accelerating beyond expectations.  ... rely on using their credit cards, the digital currency, ... for payment services led by companies in the space ... Google, Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
(Date:8/10/2015)... -- The latest 364 page report from business ... global border security market . Visiongain assesses ... Now: Border security is hard to achieve and ... critical issue you need to know about - and more ... of how this will impact your company and the border ...
(Date:8/5/2015)... , August 5, 2015 ... titled "Facial Recognition Market - Global Industry Analysis, Size, ... global market for facial recognition is forecast to reach ... by increased demand for surveillance systems by civil and ... number of crimes and terrorist activities across the globe ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... Md Hopeful signs that humans and tigers can ... has committed to doubling populations of the critically endangered ... scientist Neil Carter provides evidence that when Nepalese villagers ... the resulting landscape changes can benefit both people and ...
... have elucidated a key mechanism by which cancer cells ... and raw materials required to sustain runaway growth. ... Ludwig Cancer Research study also reveals how the aggressive ... therapies that should disrupt this capabilityknown as the Warburg ...
... N.C. , Oct. 21, 2013 Washington Eye Center is ... Care, effective immediately. The name was chosen to better reflect the ... to expect from Eastern North Carolina,s leading ... Care will be the new name of the locations in ...
Cached Biology News:In Nepal, villagers' land uses help people and tigers, study finds 2In Nepal, villagers' land uses help people and tigers, study finds 3Targeting cancer's sweet tooth 2Targeting cancer's sweet tooth 3Washington Eye Center is now Precision Eye Care 2
(Date:9/1/2015)... ... September 01, 2015 , ... GenoCAD, a leading provider ... version of its flagship DNA design platform, which has been enhanced to boost ... numerous genetic parts, which in turn can be recombined using specific sets of ...
(Date:8/31/2015)... Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... million. The orders are for air emission abatement projects in ... is a large order for a municipality in the ... replacing a competitor,s system that failed to meet the customer,s ... solutions," said Derek S. Webb , President and Chief ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/v7fdpx/argentina ) ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.17 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ) ... & Africa Biomedical Sensors Market - Growth, Trends & ... The Middle East & ... by 2018 at a CAGR of 3.26% over the ... Biomedical sensors that are adaptable to the genetic formulation ...
Breaking Biology Technology:GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2
... REDWOOD CITY, Calif., Jan. 11 Maxygen, Inc.,(Nasdaq: ... the development of,improved protein drugs, today announced that ... Annual Healthcare Conference on Thursday,January 17, 2008 at ... officer, will present. A live webcast of the ...
... to Deliver Specialized Equipment Free of Charge, AUSTIN, ... (BIATX) today announced that a six-year-old boy in Austin, ... baby syndrome,will receive a specialized wheelchair and other medical ... a victim of,shaken baby syndrome, passed away on February ...
... Biomoda, Inc. (OTC,Bulletin Board: BMOD) ( http://www.biomoda.com ) ... has joined Biomoda as a Senior,Research Specialist focused ... the early detection of lung cancer., Dr. ... scientist at,Lovelace Respiratory Research Institute in Albuquerque. He ...
Cached Biology Technology:Texas Boy Receives Wheelchair From New Hampshire Couple's Recently Deceased Granddaughter 2Biomoda Hires Senior Scientist to Expand Research & Development Effort 2