Navigation Links
454 sequencing identifies HIV drug resistance at early stage

454 Life Sciences, a member of the Roche group, and a Yale School of Medicine researcher today announced that they have used the company’s Genome Sequencer™ system to identify previously undetectable rare drug resistant HIV variants in samples from an earlier performed clinical trial. The work, presented today by Michael Kozal, M.D. of the Yale University School of Medicine and the VA CT Health Care System, was a blinded-retrospective analysis of 258 blood samples taken before drug treatment from HIV infected individuals. The results were presented today at the XVI International HIV Drug Resistance Workshop in Barbados and showed that the fraction of patients that harbored resistance mutations is at least twice as high as previously thought. Most low level mutations are undetectable by current resistance testing methods that are used in the clinic. The additional low abundant resistant variants detected by Ultra Deep sequencing were found to be extremely important as it enabled the prediction of early antiretroviral treatment failure with strong statistical significance.

“Current genotypic resistance technology available to clinicians is limited to detecting resistance mutations that are present at levels of approximately 20% or greater in the circulating viral population in a patient. Thus, the current technology used in the clinic may miss many low-level resistant HIV strains which can grow rapidly under drug selection pressure and lead to therapy failure. This retrospective study clearly shows that even resistance mutations present at the 1% level lead to premature failure of therapy” explained Michael Kozal, M.D. the senior author on the study. “In the future, hopefully clinicians can use this knowledge to choose better antiretroviral drug combinations that have the ability to suppress these resistant HIV strains which will lead to better clinical responses in patients.”

While treatment of HIV has been largely successful, with dramatic incr
'"/>

Source:Russo Partners, LLC


Page: 1 2

Related biology news :

1. Color-blind method opens new doors in DNA sequencing
2. Gene sequencing explains bioremediation bug
3. NHGRI targets 12 more organisms for genome sequencing
4. NHGRI expands effort to revolutionize sequencing technologies
5. Detection of DNA on nanotubes offers new sensing, sequencing technologies
6. Genome sequencing is for ecologists, too
7. NHGRI announces new sequencing targets
8. Nanopore method could revolutionize genome sequencing
9. Mitochondrial DNA sequencing tool updated
10. NHGRI announces latest sequencing targets
11. Columbia University licenses next-generation DNA sequencing technology
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: sequencing identifies HIV drug resistance early stage

(Date:8/27/2014)... Ebola is a rare, but deadly disease that exists ... One of the most lethal strains is the Sudan ... Africa, SUDV has caused widespread illness, even as recently ... journal ACS Chemical Biology , researchers now report ... infected with SUDV. , John Dye, Sachdev Sidhu, Jonathan ...
(Date:8/27/2014)... Outstanding basic research, a growing focus on ... patient care have earned the Herbert Irving Comprehensive ... (CUMC) and NewYork-Presbyterian Hospital an $18 million, five-year ... Institute (NCI). The grant renews the center,s status ... Centers in New York City and one of ...
(Date:8/27/2014)... shown that excessive iron is closely associated ... studies from Chunyan Guo and co-workers from ... that baicalin prevented iron accumulation after substantia ... expression, and increased ferroportin 1 expression in ... rats. However, the relationship between iron concentration ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... team led by British Antarctic Surveys (BAS) Dr Andy Smith ... ice sheet. The lake the size of Lake Windermere ... climate change and future sea-level rise. Glaciologist Dr Smith ... are camped out at one of the most remote places ...
... implications. Should children be tested for gene mutations ... cancer later in life" New research suggests ... even when any steps to reduce that risk will ... current policies., In the study published today online in ...
... PHILADELPHIA - University of Pennsylvania engineers and physicians have ... a human hair that measures electric current and delivers ... tool to probe cells with minimal intrusion and inject ... are found in almost every cell laboratory in the ...
Cached Biology News:Exploration of lake hidden beneath Antarctica's ice sheet begins 2Should children be permitted to get genetic testing for BRCA 1/2 mutations? 2Penn engineers create carbon nanopipettes that are smaller than cells and measure electric current 2
(Date:8/26/2014)... has just been added to the growing case ... the next big thing in the high-tech world ... An international collaboration of researchers led by a ... Lawrence Berkeley National Laboratory (Berkeley Lab) has reported ... in photo-excited MX2 materials. The recorded charge transfer ...
(Date:8/26/2014)... ALPHARETTA, Ga. , Aug. 26, 2014 /PRNewswire/ ... ambient biological sample collection, stabilization and transportation, announced ... with Laboratory Procurement Services, LLC (LPS) of ... ViveST line of products in the United ... a new class of ambient temperature dried biological ...
(Date:8/26/2014)... 2014 The global market for molecular ... 2020, according to a new study by Grand View ... and the subsequent introduction of advanced cancer diagnostic technologies ... over the next six years. Moreover, the growing global ... cancer, coupled with disease triggering lifestyle habits such as ...
(Date:8/26/2014)... , Aug. 26, 2014 Trovagene, ... Next Generation Dx Summit; Moving Assays to the ... Detection and Monitoring of Cell Free Tumor DNA ... analytical component of its Precision Cancer Monitoring (PCM) ... clinical sensitivity for the detection of tumor DNA ...
Breaking Biology Technology:Competition for graphene 2ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 3World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 4World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 5World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 6Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4
... Pharma S.A., a,global specialty pharmaceutical company focused ... company, Galderma Laboratories, Inc., has,completed its acquisition ... result of the transaction, CollaGenex has become ... "We are pleased to complete the acquisition ...
... Signalife, Inc.,(Amex: SGN ) has confirmed that ... and Chief Executive Officer, Dr. Lowell T. Harmison, has,scheduled ... EDT., Dr. Harmison stated: "Now that Signalife has ... manufacturing and shipping,product, I am pleased to provide direction ...
... April 11 Dilon Technologies, Inc., a,manufacturer and ... nine additional Dilon 6800 orders have been secured ... The Dilon 6800, a high-resolution, small field-of-view ... a molecular,breast imaging technique used for the early ...
Cached Biology Technology:Galderma Completes Acquisition of CollaGenex 2Galderma Completes Acquisition of CollaGenex 3Galderma Completes Acquisition of CollaGenex 4Signalife Announces Webcast 2Signalife Announces Webcast 3
Anti-Mouse Qa.m8, Ascites (Clone 5035-24.1) (mouse IgG3)...
... contains 4 deuterium atoms at the 9, 10, ... use as an internal standard for the quantification ... is produced by incubation of linoleic acid with ... to inhibit the adhesion of tumor cells to ...
...
...
Biology Products: