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3D Atlas Will Help Navigate The Spinal Cord

of neurochemical markers (chemoarchitecture). Many pathways in the nervous system contain a particular protein which can be demonstrated in tissue sections using a technique called immunohistochemistry that involves the use of specific antibodies. The often distinct distribution of these chemicals in the rat spinal cord is like a "signature" for one type of nerve cell and its processes.

Because most of the neurochemical proteins are conserved across species, they are present not only in a particular group of nerve cells in the rat, but also in its homologue (corresponding structure) in the human. The study will, for the first time, comprehensively depict transverse and horizontal sections, reproduce these in 3D and make some parallel observations in the human spinal cord (when tissue becomes available), thus supporting both experimental and clinical approaches.


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Source:Prince of Wales Medical Research Institute


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