Navigation Links
3D Atlas Will Help Navigate The Spinal Cord

Professor George Paxinos and Dr Yuri Koutcherov of the Spinal Injuries Research Centre at the Prince of Wales Medical Research Institute have been awarded ~$200,000 by the Christopher Reeve Paralysis Foundation to prepare a three-dimensional (3D) atlas of the rat spinal cord over the next two years.

Christopher Reeve met with Institute scientists during his visit to Australia in 2003 and was impressed with their work in spinal injuries research. Professor Paxinos is a world leader in the preparation of brain atlases, being the author of atlases of human, monkey, rat and mouse brains used world-wide by neuroscientists in all areas.

As a geographic map to a traveller, a map of the spinal cord is needed by scientists studying the spinal cord of humans. Currently the principal animal for spinal cord injury research is the rat. There is no comprehensive and accurate atlas of the rat spinal cord; indeed, the problem is greater: there is no comprehensive structural study of the spinal cord of any species, including humans.

A new project supported by the Christopher Reeve Paralysis Foundation is designed to redress this shortcoming. The results will provide (a) the fundamental structural map of the rat spinal cord, (b) make relevant comparisons with the human spinal cord and demonstrate the anatomical principles or generalizations of its organization, and (c) provide the 3D stereotaxic space designed to become the knowledge management environment for experimental and, eventually, clinical observations.

Though not itself directed at a cure for the consequences of spinal cord injury, the project will accelerate progress of such research because it will permit scientists to navigate seamlessly between the rat and human spinal cords to test hypotheses inspired by human considerations and relate data from experiments in animals back to humans.

The proposed description of the structure of the spinal cord will be based on a comprehensive use of neurochemical markers (chemoarchitecture). Many pathways in the nervous system contain a particular protein which can be demonstrated in tissue sections using a technique called immunohistochemistry that involves the use of specific antibodies. The often distinct distribution of these chemicals in the rat spinal cord is like a "signature" for one type of nerve cell and its processes.

Because most of the neurochemical proteins are conserved across species, they are present not only in a particular group of nerve cells in the rat, but also in its homologue (corresponding structure) in the human. The study will, for the first time, comprehensively depict transverse and horizontal sections, reproduce these in 3D and make some parallel observations in the human spinal cord (when tissue becomes available), thus supporting both experimental and clinical approaches.


'"/>

Source:Prince of Wales Medical Research Institute


Related biology news :

1. Spinal cord bridge bypasses injury to restore mobility
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
Breaking Biology Technology: