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3 proteins may play important role in nerve-cell repair

ure to learn more about the three proteins and their involvement in cAMP regulation.

The researchers added additional copies of the three genes to the cells to increase the levels of the proteins, and then used a laboratory technique called RNA intereference to turn off production of the proteins.

Of the three molecules, GPR3 was the most abundant in the nerve cells, while GPR12 was the most potent at stimulating growth of the nerve extensions. The study showed that blocking GPR3 greatly slows the growth of the nerve extensions. The researchers reversed this effect by restoring either GPR3 or GPR12 in the cells.

High levels of the three proteins were also linked to higher levels of cAMP, with GPR6 and GPR12 increasing the level twofold to threefold.

"Taken together," Saeki says, "our findings indicate that these three proteins improve growth of neuronal extensions even in the presence of inhibitory molecules, and we are very keen to find out whether the approach can be translated in preclinical animal models of stroke or spinal cord injury."
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Source:Ohio State University


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