Navigation Links
3 proteins may play important role in nerve-cell repair

Some mature brain cells can grow new extensions when the amount of three particular proteins on their surface increases, a new study shows.

The research examined three related receptor proteins, called GPR3, GPR6 and GPR12, on nerve cells in the brains of rats.

When researchers increased the amount of the three proteins, the cells grew extensions that were up to three times longer than those on nerve cells with normal levels of the proteins, and the extensions grew four to eight times faster than in control cells.

"Our findings suggest that these three proteins could be important targets for treating stroke, brain and spinal cord injuries and also neurodegenerative diseases," says principal investigator Yoshinaga Saeki of the Ohio State University Medical Center.

The study is published in the April 6 issue of the Journal of Biological Chemistry.

Increased amounts of the proteins were associated with a significant rise in the level of an important signaling molecule inside the nerve cells called cAMP. This molecule plays a key role in regulating nerve-cell growth, differentiation and survival, and the regeneration of long parts of the cell called axons that carry the nerve impulses.

Levels of cAMP drop in mammalian nerve cells as they mature, and this is thought to explain, in part, why mature nerve cells cannot regenerate damaged axons.

"Our findings provide additional evidence that cAMP plays an important role in axon growth and suggest that these receptors are likely to play a major role in regulating cAMP production in nerve cells," says Saeki, an associate professor of neurological surgery and chief of Ohio State's Dardinger Laboratory for Neuro-oncology and Neurosciences.

In this study, first author Shigeru Tanaka, a postdoctoral fellow in Saeki's laboratory, and his colleagues used nerve cells obtained from the brain tissue of rats and mouse neuroblastoma cells growing in cult
'"/>

Source:Ohio State University


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. UWs Rosetta software to unlock secrets of many human proteins
3. Global analysis of membrane proteins
4. UNC plant researchers discover proteins interact to form hair-trigger protection against invaders
5. Mad cow proteins successfully detected in blood
6. Researchers develop new method for facile identification of proteins in bacterial cells
7. Hopkins scientists uncover tags that force proteins to cell surface
8. Researchers create functioning artificial proteins using natures rules
9. UCSD discovery may provide novel method to generate medically useful proteins
10. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
11. A real time look at interactions between RNA and proteins
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: proteins may play important role nerve cell repair

(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ... in general the State of Washington,s ... a new enrollment and central issuance system for driver,s licenses ... The project planning and development will start in January ...
(Date:1/22/2015)... DETROIT , Jan. 13, 2015 Technology Showcase, Hall ... iris-based identity authentication solutions, today announced it will showcase its ... and developed by the Department of Energy,s Oak Ridge ... International Auto Show . EyeLock,s iris identity authentication technology is ...
(Date:1/22/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a ... the recent success of the Wocket™ smart wallet at CES 2015 in ... was named as one of the "11 Hot Products at CES" in ... At CES So Far" by Newseveryday.com and "The top 10 gadgets from ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... research shows that in sub-Saharan Africa the virus responsible for ... and the African buffalo are important natural reservoirs for the ... open-access journal of the American Society for Microbiology, sheds light ... emerged in sub-Saharan Africa and identifies patterns of spread in ...
... suggests the southern portion of the Amazon rainforest is at ... drying than projections made by the climate models used in ... (IPCC). If severe enough, the loss of rainforest could cause ... dioxide into the atmosphere. It could also disrupt plant and ...
... A California walking stick insect that has evolved to ... camouflages well with broader leaves and a form with ... better with needle-like leavescan markedly affect its broader ecological ... with the plant it,s living on. The new ...
Cached Biology News:Foot and mouth disease in sub-Saharan Africa moves over short distances, wild buffalo are a problem 2Risk of Amazon rainforest dieback is higher than IPCC projects 2Risk of Amazon rainforest dieback is higher than IPCC projects 3Poorly camouflaged insects can kick off a cascade of ecological impacts, new CU-Boulder study finds 2Poorly camouflaged insects can kick off a cascade of ecological impacts, new CU-Boulder study finds 3
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)...   Cypher Genomics, Inc., the leading genome ... SQNM ), the leading molecular diagnostics company, today ... prenatal tests (NIPT). Through this agreement, Sequenom will ... advance analysis of clinically-relevant fetal sub-chromosomal variants detected ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... libraries with high-titer efficiency and larger insert,potential ... cDNA Expression Libraries , Katherine Felts ... ,Anna Waesche Peter Vaillancourt ,Stratagene , ... expression libraries inserted into the,high-titer retroviral vector ...
... High-quality plasmid DNA for all demanding molecular ... Jeff Braman ,Stratagene , A new technique ... reliably isolate,high-purity plasmid DNA. The convenient spin-format ... columns, and alcohol precipitations, while,easily accommodating simultaneous ...
... RT-PCR systems excel at amplifying challenging targets ... Hogrefe ,Stratagene , We compared Stratagenes prostar RT-PCR ... see how well they performed.,The ProSTAR HF single-tube ... ,Precision DNA polymerase blend * and a convenient ...
Cached Biology Technology:Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 2Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 3Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 4Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 5Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 6Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 7Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 8Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 9Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 10Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 11A Simple and Rapid Technique to Purify High-Quality Midiprep DNA 2A Simple and Rapid Technique to Purify High-Quality Midiprep DNA 3A Simple and Rapid Technique to Purify High-Quality Midiprep DNA 4Performance Comparisons of Commercial RT-PCR Systems 2Performance Comparisons of Commercial RT-PCR Systems 3Performance Comparisons of Commercial RT-PCR Systems 4Performance Comparisons of Commercial RT-PCR Systems 5Performance Comparisons of Commercial RT-PCR Systems 6Performance Comparisons of Commercial RT-PCR Systems 7Performance Comparisons of Commercial RT-PCR Systems 8
...
... APAgene kits are designed to rapidly ... using our patented APA Technology. APAgene provides ... competitive price. All necessary ingredients are provided ... can be used for gap filling, localized ...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
Biology Products: