Navigation Links
3-D model reveals secrets of metastasis

"Our findings help explain why two-dimensional assays for metastasis-inhibiting drugs do not effectively predict their effects in tissue," says Lauffenburger, who is director of MITâ?super>TMs Biological Engineering Division. He believes pharmaceutical companies will eventually use three-dimensional assays, accompanied by appropriate computational models such as that also recently published by Zaman (in Biophysical Journal in 2005), to determine how drugs affect metastasis.

But technology must improve before more complicated 3D studies are attempted. For his 3D work Zaman worked with one sample at a time, using a special confocal microscope at the Whitehead-MIT BioImaging Center. The microscope divided each specimen into virtual slices, generating a new stack of images every 15 minutes.

"It took me about a year to get enough data because the microscope wasnâ?super>TMt designed for high-throughput experiments," he says. Fortunately, the BioImaging Center has one of the most powerful sets of computers at MIT and the imaging processing and analysis went quite quickly.

"Muhammad was successful for two reasons," says Matsudaira. "His computational model predicted what would happen in virtual experiments and then he was able to go straight to test the predictions with these complicated 3D experiments. As a result, the sophisticated models of cell movement enhance our understanding of key biological processes, including metastasis."
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2

Related biology news :

1. Scientists identify new model Of NK cell development
2. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
3. Molecular models advance the fight against malaria
4. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
5. Genetic therapy reverses nervous system damage in animal model of inherited human disease
6. Disease progression model of pancreatic cancer developed by Penn researchers
7. A new way to share models of biological systems
8. Understanding biases in epidemic models important when making public health predictions
9. Climate model links higher temperatures to prehistoric extinction
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: model reveals secrets metastasis

(Date:9/30/2014)... new research, involving mice and published in the October ... Biology , suggests that just because you can ... a team of Italian scientists have found that using ... the immune system. This damage may result in autoimmune ... inflammatory bowel disease and rheumatoid arthritis in adulthood. , ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014 /PRNewswire/ ... control solutions for the biotech and power ... its new RECONN Bioprocess Manager, an easy-to-use ... solution geared towards bioprocess development laboratories. ... have disparate bioreactor and analyzer systems. Accessing ...
(Date:9/29/2014)... A new study confirms that the exposure to tar ... than of regular cigarettes. Similarly, exposure to nicotine ... increasingly popular type of cigarette in several countries around ... of certain toxic chemicals in the smoke of these ... because lower levels of chemicals in the smoke are ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2
... differences account for some of the most of the spectacular ... plumage of peacocks, tusks on walruses and antlers on moose. ... mating is thought to be a particularly potent force ... females. However, the genetic processes responsible for producing such ...
... PAUL (05/03/2012) Vegetation, such as a patch of prairie or ... when more plant species are present, a new University of ... found that each species plays a role in maintaining a ... The study found that every additional species in a plot ...
... of California, Berkeley, scientists are drilling into ancient sediments ... clues that could help them better predict how today,s ... increasing population. The lake sediments are among the ... as far as 500,000 years. The core drilling ...
Cached Biology News:Biologists turn back the clock to understand evolution of sex differences 2Plant diversity is key to maintaining productive vegetation, U of M study shows 2Scientists core into California's Clear Lake to explore past climate change 2Scientists core into California's Clear Lake to explore past climate change 3Scientists core into California's Clear Lake to explore past climate change 4
(Date:10/1/2014)... 2014 METTLER TOLEDO’s newly improved XS ... balances as well as a dual range ... the new SmartPan™ weighing pan delivers results up to ... all balances, ergonomic design details mean users no longer ... for long periods in front of the balance. Barbara ...
(Date:10/1/2014)... 01, 2014 Weighing applications in ... the final product. However, while the pharmaceutical industry ... such as Good Manufacturing Practices (GMP) usually provide ... the manufacturer to interpret these guidelines and assess ... quality. METTLER TOLEDO experts have created a new ...
(Date:10/1/2014)... As the world takes its first steps into the ... century would mark the beginning of a new era of ... fact that the world is experiencing a rapid rise in ... Almost half of these chronic conditions are due to lifestyle ... care and intervention. While the world is experiencing a rapid ...
(Date:10/1/2014)... 2014 In response to its ... address sales, training and consumer engagement challenges, ... mobile applications to turn their clients’ visions into ... customized mobile app creations, are now featured on ... partnership with Toyota, StudioPMG created a robust cross-platform ...
Breaking Biology Technology:METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 2METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 3Comply with Weighing-Related Regulations in Pharma Manufacturing 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3Digital Agency Studio PMG Launches New Case Studies on Website 2
... products coming soon to Bioniche,s growing line of injectable ... ... Bioniche Pharma, a leading,developer and manufacturer of injectable pharmaceuticals, announced today,the acquisition ... chloride injection, USP) 10 mg/mL, 15 mL vial -- ENLON-PLUS(R) (edrophonium ...
... Moore named as Vice President, Marketing and Sales; Susan Koppy ... named as Vice President, Corporate Development, PT. ... appointment of Terrence Moore to the position of,Vice President, Marketing ... Corporate Development. Both Mr. Moore and Ms. Koppy will report,to ...
... based on cells manufactured from bone ... round, SALT LAKE CITY and HAMBURG, Germany, July ... of innovative cell therapies,for the treatment of acute kidney ... financing. The round was led by SV Life Sciences ...
Cached Biology Technology:Bioniche Pharma Acquires Baxter's ENLON(R) and ENLON-PLUS(R) 2Transcept Pharmaceuticals Appoints Key Senior Executives 2Transcept Pharmaceuticals Appoints Key Senior Executives 3Transcept Pharmaceuticals Appoints Key Senior Executives 4AlloCure Inc. Closes $14.5MM Series A Round to Develop a Stem Cell Therapy for Acute Kidney Injury 2AlloCure Inc. Closes $14.5MM Series A Round to Develop a Stem Cell Therapy for Acute Kidney Injury 3
RAT ANTI MOUSE METALLOPHILIC MACROPHAGES...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Form: Ready to use Applications: ELISA...
Form: Ready to use Applications: ELISA...
Biology Products: