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15 generations of untrained jocks, couch potatoes show big physiological adaptations

as the mechanisms responsible for the "natural" improvements in muscular, cardiovascular and pulmonary oxygen delivery.

Further in the future the physiologists hope that identifying these genes and underlying processes could provide insight into human attitudes toward exercise and lead to therapies to improve oxygen delivery in patients with muscular, cardiovascular and respiratory diseases.

*Paper presentations: These research results reflect three concurrent presentations at IUPS. Each is listed below with the lead author. Other authors involved in all three papers are listed below. The authors will be in attendance 12:30 p.m.-3 p.m. Tuesday April 5, Physiology session 936, Physiological genomics of the respiratory system. Their boards, A487-A489, will be on view 7:30 a.m. - 4 p.m.

"VO2max and muscle O2 transport in rats continue to diverge with further selective breeding for endurance running." Richard A. Howlett, University of California at San Diego. 936.2/A488.

"Cardiovascular differences between rats selectively bred for endurance running capacity." Scott David Kirkton, UCSD, 936.3/A489.

"15 generations of selective breeding for endurance running capacity in rats is associated with enhanced lung structure and function not seen at generation 7." Patrick G. Giuliano (this paper only), UCSD. 936.1/A487.


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Source:American Physiological Society


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