Navigation Links
U-M team recovers ancient whale in Egyptian desert

Scientists at Fred Hutchinson Cancer Research Center have, for the first time, induced a state of reversible metabolic hibernation in mice. This achievement, the first demonstration of "hibernation on demand" in a mammal, ultimately could lead to new ways to treat cancer and prevent injury and death from insufficient blood supply to organs and tissues.

"We are, in essence, temporarily converting mice from warm-blooded to cold-blooded creatures, which is exactly the same thing that happens naturally when mammals hibernate," said lead investigator Mark Roth, Ph.D., whose findings will be published in the April 22 issue of Science.

"We think this may be a latent ability that all mammals have -- potentially even humans -- and we're just harnessing it and turning it on and off, inducing a state of hibernation on demand," said Roth, a member of Fred Hutchinson's Basic Sciences Division.

During a hibernation-like state, cellular activity slows to a near standstill, which reduces dramatically an organism's need for oxygen. If such temporary metabolic inactivity ?and subsequent freedom from oxygen dependence ?could be replicated in humans, it could help buy time for critically ill patients on organ-transplant lists and in operating rooms, ERs and battlefields, Roth said.

"Manipulating this metabolic mechanism for clinical benefit potentially could revolutionize treatment for a host of human ills related to ischemia, or damage to living tissue from lack of oxygen," said Roth, also an affiliate professor of biochemistry at the University of Washington School of Medicine.

Collaborators on the research included first author Eric Blackstone, a graduate research assistant in Roth's laboratory and a member of the joint Fred Hutchinson/University of Washington Molecular and Cellular Biology Program; and co-author Mike Morrison, Ph.D., a staff scientist in Roth's lab.

Clinical applications of induced metabolic hibernation could include t
'"/>

Source:


Page: 1 2 3 4 5

Related biology news :

1. Researchers find missing genes of ancient organism
2. Family trees of ancient bacteria reveal evolutionary moves
3. Scientists find fossil proof of Egypts ancient climate
4. Deep sea algae connect ancient climate, carbon dioxide and vegetation
5. Analysis of flower genes reveals the fate of an ancient gene duplication
6. World-first technology enables study of ancient bacteria
7. Did humans cause ecosystem collapse in ancient Australia?
8. MBL researchers probe how an ancient microbe thrives and evolves without sex
9. A salty tale: New bacterial genome sequenced from ancient salterns
10. UF scientists reveal ancient origin of vertebrate skeleton
11. UF scientists reveal ancient origin of vertebrate skeleton
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: team recovers ancient whale Egyptian desert

(Date:6/17/2013)... by fungi, bacteria, and algae, is a common component ... used in the medical field it,s approved by ... fluids and used during surgery as a substance that ... other drugs. , Now Profs. Ehud Gazit and Daniel ... and Biotechnology and the Sagol School of Neuroscience, along ...
(Date:6/17/2013)... will be the topics under discussion during the ... the third consecutive year, this will be a ... experiences among members of Academy, Business, Educators, Entrepreneurs, ... speakers: Elisa Martn Garijo (IBM South Europe), Chris ... Mary O,Donovan (Hovione), among others. E3 Forum - ...
(Date:6/17/2013)... available in French . ... older mice with Alzheimer,s disease can be reversed with treatment. ... Hospital - The Neuro, at McGill University and at Universit ... receptor in the brain of mice with advanced Alzheimer,s disease ... the Journal of Neuroinflammation in May, also suggest ...
Breaking Biology News(10 mins):Artificial sweetener a potential treatment for Parkinson's disease 2'E3 Forum -- Education, Employment & Entrepreneurship on a Global context' 2Blocking overactive receptor in Alzheimer's recovers memory loss and more 2
... Gasterosteus aculeatus , is one of the most thoroughly ... particularly useful model for understanding variation in physiology, behavior, ... in the wild. On biological levels from molecular ... with the population level, it has proven far more ...
... a little gooey, but it,s not turning mums, brains into ... University. The study conducted by the Centre for ... fears mothers may have that pregnancy affects their cognitive functions, ... findings have been released as part of Mental Health Week, ...
... ability to respond? Biodiversity in a Warmer World, published ... Science , illustrates that cross-disciplinary research fostered by ... this urgent debate. , As an extremely diverse region ... the most to lose as a result of global ...
Cached Biology News:Fitness in a changing world 2Fitness in a changing world 3Pregnancy not turning minds to mush: Study 2Smithsonian perspective: Biodiversity in a warmer world 2
(Date:6/17/2013)... June 17, 2013 zuChem Inc., ... health and nutrition, announced today that the United ... 2 patents - US 8,367,346 entitled “Methods for ... entitled "Process for producing D-Mannitol." These two patents ... of natural food sweetener products from abundant, renewable ...
(Date:6/17/2013)... June 17, 2013 Cedars-Sinai Medical Center, ... the country, recovered more than $300 million by ... of OnBase, Hyland Software,s enterprise content management ... provide a common revenue cycle management platform to ... were in place for both hospital and physician ...
(Date:6/17/2013)... COLUMBUS, Ohio , June 17, 2013 /PRNewswire/ ... has raised an additional $2.5 million from Radius ... $11.5 million. The Series B originally raised $9 ... with participation by existing investor, Charter Life Sciences. ... system is the first and only product that ...
(Date:6/17/2013)... , June 17, 2013 /PRNewswire-iReach/ -- The Greater ... Riedford , President/Founder of Riedford Management, Inc. to its Board ... a member of the Chamber,s Board of Advisors," said ... is one of the most prestigious positions to hold in ... experience our new board members will contribute." The ...
Breaking Biology Technology:zuChem Receives Two Polyol Patents 2Cedars-Sinai Medical Center Recovers More Than $300 million in AR with Hyland Software's OnBase 2Cedars-Sinai Medical Center Recovers More Than $300 million in AR with Hyland Software's OnBase 3Minimally Invasive Devices Adds $2.5 Million to its Series B 2Raleigh Chamber Names Bob Riedford to Board of Advisors 2
... Graduate Institute,(KGI) in collaboration with City of Hope, ... launch of its new Certificate in Bioscience,Management program ... funding to allow a limited number of City ... scholarships that will cover tuition., "KGI has ...
... ALTO, Calif., Aug. 14 CV Therapeutics,Inc. (Nasdaq: ... from the,European Medicines Agency (EMEA) for the brand name ... announced that the EMEA had granted,marketing authorization for ranolazine ... brand name Latixa., "Securing approval for the Ranexa ...
... Eric P. Loukas, Industry Veteran, Named as CEO ... Co-Founder, Named as President and COO, ALTAMONTE SPRINGS, ... specialty biotechnology company focused on,in-licensing and commercialization of niche ... as Chief Executive Officer,effective August 12, 2008. Current President, ...
Cached Biology Technology:City of Hope Helps KGI Launch New Management Training Program for Scientists 2City of Hope Helps KGI Launch New Management Training Program for Scientists 3CV Therapeutics Receives European Approval for the Brand Name Ranexa(R) 2Milestone Biosciences, LLC Further Strengthens Executive Management Team 2
... Select Tissue Arrays are intended for laboratory ... were fixed in neutral buffered formalin and ... diagnosis was performed by certified pathologists. ... blocks and relocated into a new recipient ...
... analysis standard is a lyophilized mixture ... alcohol; molecular weights range from 152 ... for use with the Aminex HPX-87C ... for column testing or semiquantitative determination. ...
The Odyssey Infrared Imaging System is a complete family of products that includes the Odyssey Imager, IRDye labeling reagents and Odyssey software for scan control and data analysis....
... The kit was tested on rat tissue ... a yeast ( S. cerevisae ) extract. It ... rat tissues and cell lines. Application: A simple ... sub-cellular fractions based on the detection of the ...
Biology Products: