( o the cell's interior where it could a...) Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

o the cell's interior, where it could activate several cellular enzymes, called caspases, which in turn initiate cell degradation. They also found that estradiol caused complete tumor regression in mice that had been injected with the MCF-7:5C breast cancer cells.

"These laboratory data have important clinical implications, particularly for the use of aromatase inhibitors as long-term therapy," write the authors, "and they suggest that, if and when resistance to aromatase inhibition occurs, a strategy of treatment with estrogen ?may be sufficient to kill the cancer and control disease progression."

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Source:Journal of the National Cancer Institute


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