Navigation Links
Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance

Discoveries by a research team from Maine could help to settle a long-standing debate in genetics.

Some genes are seemingly inseparable in nature; they form a haplotype-a set of genes inherited as a unit. Some researchers support the notion that mapping haplotypes may be more significant than mapping the genome. The haplotype map could allow researchers to look for a single variation in the complex genetic code and know all the variations associated with it, since all are part of the same haplotype.

The Maine research group challenges that proposal, demonstrating that genes within a haplotype function independently. The group included Dr. Antonio Planchart of the Mount Desert Island Biological Laboratory and the College of the Atlantic, Bates College undergraduate Jennifer Reynolds, and Dr. John Schimenti, adjunct senior staff scientist at The Jackson Laboratory.

In feral house mice, 20 percent of the population carries one copy of the t haplotype whereas the remaining 80 percent carries the wild haplotype. According to the distribution predictions set out by Gregor Mendel, the 19th century Austrian monk who studied inheritance in flowering pea plants, males and females should pass the t haplotype to half their offspring.

In a strange twist to what Mendel might have predicted, the males pass the t haplotype to nearly 100 percent of their offspring (a phenomenon known as "transmission ratio distortion")-practically twice the Mendelian prediction.

Stranger still, male and female mice that inherit the t haplotype from both parents typically do not survive, but in the rare instances when they do, the overwhelming majority of males are sterile.

Until now, most geneticists suspected that both transmission ratio distortion and sterility were due to the same mutations in a small number of genes residing in the t haplotype. The hypothesis was logical since the phenomena of transmission ratio distortion and sterility always mappe d to the same regions within the t haplotype.

To test this hypothesis, the Maine researchers closed in on a region of the t haplotype known to be involved in these phenomena. They used this information to develop transgenic mice that carried the candidate region derived from the wild haplotype.

When the transgenic region segregated with the t haplotype, the researchers noted that males carrying two copies of the t haplotype plus the transgenic region were fertile and showed no transmission ratio distortion. Therefore, the scientists realized, two genes must be involved-one controlling sterility and a yet-to-be discovered gene regulating transmission ratio distortion.

Dr. Planchart commented, "For more than 50 years, researchers have sought the biochemical and molecular basis of these phenomena. This work represents a landmark study of the genetics of the t haplotype-it shows for the first time that different genes within the haplotype cause transmission ratio distortion and sterility."

The research is published in the March 1 issue of the Proceedings of the National Academy of Sciences.


'"/>

Source:The Jackson Laboratory


Related biology news :

1. New online portal merges vast data on Gulf of Maine ecosystem
2. UMaine teams with fishermen to study affects of trawling on seafloor ecology
3. The diversity of marine life in the Gulf of Maine region is much greater than previously thought
4. Researchers discover way to make cells in the eye sensitive to light
5. Researchers find how protein allows insects to detect and respond to pheromones
6. Researchers Uncover Key Step In Manufacture of Memory Protein
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   ... data sensor technology, and STMicroelectronics (NYSE: ... spectrum of electronics applications, announced today the launch ... kit for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, ...
(Date:12/15/2016)... BADEN-BADEN, Germany , December 15, 2016 /PRNewswire/ ... services provider, today announced an agreement with NuData Security, ... join forces. The partnership will enable clients to focus on ... with local data protection regulation. ... In order to provide a one-stop ...
(Date:12/15/2016)... Dec. 14, 2016 "Increase in mobile transactions ... The mobile biometrics market is expected to grow from ... by 2022, at a CAGR of 29.3% between 2016 ... as the growing demand for smart devices, government initiatives, ... "Software component is expected to grow at a ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... San Diego, CA (PRWEB) , ... January 24, ... ... pioneering the development of label-free graphene biosensor assays for fragment-based screening, ... 1317 at the 2017 Society for Laboratory Automation and Screening (SLAS) conference in ...
(Date:1/24/2017)... (PRWEB) , ... January 23, 2017 , ... ... that supports innovative science through unique partnerships, seeks outstanding early career nominees for ... innovation is critical to meeting the needs of a world in which one ...
(Date:1/24/2017)... PUNE, India , January 23, 2017 ... "Humanized Mouse Model Market by Type (Genetic, Cell-based (CD34, ... diseases) & End User (Pharmaceutical & Biotech Companies, CRO) ... report studies the global Humanized Mouse Model Market for ... is expected to reach USD 116.0 Million by 2021 ...
(Date:1/23/2017)... ... 23, 2017 , ... USARAD Holdings Inc., a leading US ... adding 65 new US and international facilities to its client base. Some notable ... one of US largest imaging center chains. USARAD continued its global expansion strategy ...
Breaking Biology Technology: