Navigation Links
Gladstone investigators discover how resting T cells avoid HIV infection

Scientists have discovered the mechanism that enables some CD4 T cells -- the main target of HIV -- to thwart the virus. The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD.

The researchers, led by Ya-Lin Chiu, PhD, a postdoctoral fellow in the Greene lab, investigated why resting, nondividing CD4 T cells are impervious to HIV infection, while activated, dividing CD4 T cells are not. The team discovered that a potent antiviral factor called APOBEC3G (A3G) is the key.

The team, working in cell culture, found that A3G exists in two different-sized forms -- a small form that actively repels the virus, and a large form that is completely ineffective against it. Moreover, they detected only the small form in resting CD4 T cells, where HIV fails to grow, and only the large form in activated CD4 T cells, where the virus efficiently grows and wreaks havoc. They further showed that blocking production of the small, active form of A3G in resting CD4 T cells was sufficient to make these normally resistant resting cells highly susceptible to HIV infection.

"Until now, the prevailing belief has been that HIV failed to infect resting T-cells due to a simple lack of some essential factor or nutrient," says Greene, a professor of medicine, microbiology and immunology at the University of California, San Francisco. "This study now shifts the paradigm, showing that resting CD4 T cells actively repel HIV infection through the action of the small, enzymatically active form of A3G, which stops the virus in its tracks."

CD4 T cells are a class of lymphocytes, or white blood cells, that fight infection by orchestrating immune responses. They have the ability to recognize specific antigens -- foreign substan
'"/>

Source:UC San Francisco


Page: 1 2 3

Related biology news :

1. Gladstone investigators identify a new protective action for the powerful anti-HIV factor, APOBEC3G
2. MUHC investigators search for the root of sexual pain in women
3. UAB scientists discover the origin of a mysterious physical force
4. Researchers discover way to make cells in the eye sensitive to light
5. Protein discovery could unlock the secret to better TB treatment
6. Newly-discovered class of genes determines ?and restricts ?stem cell fate
7. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
8. Purdue proves concept of using nano-materials for drug discovery
9. Scientists discover the cellular roots of graying hair
10. Researchers discover molecule that causes secondary stroke
11. Scientists discover unique microbe in Californias largest lake
Post Your Comments:
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/25/2015)... June 25, 2015  TAKE Solutions Ltd., a global ... the United States Patent and Trademark Office (USPTO) for ... leverages TAKE Solutions, Clinical Accelerators to reduce the time ... compared to standardization without the accelerators), thus reducing time ... At the heart of the patented Clinical ...
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... University of Leicester and University of California Los Angeles ... ,bad, cholesterol in the body. They have filed ... as a catalyst for lowering levels of ,bad, cholesterol. ... the understanding of the regulation of low-density lipoprotein (LDL) ...
... SAN ANTONIO A large, multicenter, randomized study has ... larger tumors, increased lymph node involvement and, when not ... This is the first time the relationship ... according to Jennifer A. Crozier, M.D., a medical resident ...
... LA JOLLA, CA ---- Researchers at the Salk Institute for ... cells to potentially cure sickle cell disease and many other ... blood hemoglobin. The technique uses cells from a patient,s ... capable of developing into various types of mature tissues -- ...
Cached Biology News:New advance announced in reducing 'bad' cholesterol 2Addition of trastuzumab may potentially equalize disease-free survival outcomes among obese and normal-weight patients 2Salk researchers develop safe way to repair sickle cell disease genes 2Salk researchers develop safe way to repair sickle cell disease genes 3Salk researchers develop safe way to repair sickle cell disease genes 4
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... sterilized to combat pathogen transmission. CTI’ new Medical Joysticks have an impermeable ... devices now have an operator control device that will increase healthcare worker safety ...
(Date:6/30/2015)... ... June 30, 2015 , ... Park Systems ... advanced scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize ... 'the wonder material of the 21st Century' by the researchers who were awarded ...
(Date:6/30/2015)... ... 2015 , ... With its latest polyacrylonitrile (PAN) membrane, Sterlitech ... flow rates in comparison to nylon or polyethersulfone (PES). Its unique nanofiber ... liquid flow while trapping particulates as small as 0.2 micron in width. , ...
(Date:6/30/2015)... , June 30, 2015  Custom Computer Specialists, ... today that they are silver sponsors of the Primary ... PCDC sponsor, Custom is lending their support of PCDC,s ... communities. Since its founding in 1993, PCDC ... primary care area.  PCDC has financed over 100 completed ...
Breaking Biology Technology:Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4New Nanofiber Membrane Provides Fast, Efficient Filtration 2Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2
... Madison, Wis. - A Madison company will participate newly ... NimbleGen Systems Inc., will participate in the research ... approved for a National Cancer Institute grant that ... work with the University California, San Diego (UCSD) ...
... ARI Network Services, Inc., a provider of electronic parts ... Wednesday reported increased revenues and record net income for the ... fiscal 2005 were $13.7 million, a 2% increase from revenues ... to $2.1 million or $0.32 per diluted share, from operating ...
... Inc. has filed suit against three companies, seeking rulings ... on Tuesday. The suits were filed in federal court in ... Digene Corp., seeking a court ruling supporting Third Wave's ... ,On Tuesday, Third Wave filed suit against Chiron Corp. ...
Cached Biology Technology:NimbleGen to be part of new cancer study 2Third Wave files patent suits against Digene, Chiron and Bayer 2
Blank Calibration Particles, 3.0-3.4 mu m 5 ml...
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
Rabbit polyclonal to Phosphothreonine-X-Phosphotyrosine (HRP) ( Abpromise for all tested applications)....
Rat integrin a6b1, mainly associated with epithelial cells. Does not react with rat fibroblasts....
Biology Products: