Navigation Links
Worm genes KO'd
Date:4/25/2010

SALT LAKE CITY, April 25, 2010 Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing knockout mice. Kent Golic found a way to cripple fruit fly genes. Now, biologist Erik Jorgensen and colleagues have devised a procedure for knocking out genes in nematode worms.

"We developed a method that allows us to walk through the worm genome and determine the function of each gene, and thereby infer the function of these genes in humans," says Jorgensen, a biology professor, senior author of a new study outlining the technique, and an investigator with the Howard Hughes Medical Institute.

The study shows how a transposon or "jumping gene" can be used to delete specific genes from the 1-millimeter-long nematode worm, Caenorhabditis elegans. It was scheduled for online publication Sunday, April 25 in the journal Nature Methods.

"We are trying to understand how genes work and are regulated, and the easiest way to do that is to use a simple organism," says University of Utah postdoctoral fellow Christian Frkjr-Jensen, the study's first author. "The amazing thing is that cellular processes in a lowly worm are similar to the biology in humans. We've made it much easier and faster to change the genetic blueprint of a simple worm so we can study and understand how genes are regulated."

Jorgensen adds: "We want to know what human genes do because they allow us to do all the wonderful things we do run, speak, live and understand what goes wrong in genetic diseases and how we can possibly treat them."

Capecchi, a distinguished professor of human genetics, shared the 2007 Nobel Prize in Physiology or Medicine with two other researchers who independently developed gene targeting in mice in the 1980s. Golic, a professor of biology, published his key papers on targe
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm genes KO'd
(Date:2/5/2015)... TRIANGLE PARK, North Carolina , 5. ... sein 35. Jahr als spezialisiertes Logistikunternehmen und ... Position als einzige klinische Logistikfirma (Clinical Logistics ... Die Kernbotschaft der neuen Kampagne lautet ... und Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... 2015   Epic Sciences , a precision diagnostics company ... Murali Prahalad , Ph.D., president and CEO, is scheduled ... (PMWC) 2015: Silicon Valley, which is taking place at the ... on January 26-28, 2015. Dr. Prahalad ... Biomarkers." Last year, Epic Sciences was a finalist in the ...
(Date:2/5/2015)... Jan. 27, 2015   Marvin Test ... deployed, innovative test solutions for military, aerospace, ... of its TS-323 GENASYS Test Platform ... (LMSSC). GENASYS is a high-performance PXI-based system ... applications that require performance functional testing. GENASYS ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
... studies appearing in a recent issue of Cell ... http://www.ingentaconnect.com/content/cog/ct/ , evaluate stem cells derived from dental tissues ... appropriate for transplantation purposes. Induced pluripotent stem ... A Brazilian and American team of researchers used ...
... who invented a disease-fighting, anti-aging compound using nano-particles from ... Sanofi BioGENEius Challenge Canada (SBCC)., Her super anti-oxidant compound ... by neutralizing more of the harmful free-radicals found in ... a Grade 12 student at Waterloo Collegiate Institute, was ...
... of California, Riverside has identified a fungus that has been ... backyard avocado and landscape trees in residential neighborhoods of Los ... Fusarium . Scientists are working on ... Tea Shot Hole Borer ( Euwallacea fornicatus ), ...
Cached Biology News:2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes 22 Cell Transplantation studies impact dental stem cell research for therapeutic purposes 3Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles 2Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles 3Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles 4Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles 5Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles 6Beetle-fungus disease threatens crops and landscape trees in Southern California 2
(Date:2/27/2015)... , Feb. 27, 2015  Steep Hill, the industry ... and internationally, intends to open a full service medical ... Mexico , bringing advanced scientific tools and methodology ... Steep Hill is currently the only laboratory licensed ... potency and contaminant testing in order to meet the ...
(Date:2/26/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... that develops and commercializes proprietary technologies and products for ... results for the fiscal first quarter ended December  31, ... Canadian dollars (CAD), unless otherwise stated. ... business from our existing customers and add to our ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The Movement ... demonstration to support life extension technologies and awareness. The ... Universal Coordinated Time, on March 21st 2015, in a ... , Eric Schulke, Founder of MILE, says, “Our ... with urgency. The Movement for Indefinite Life Extension is ...
(Date:2/26/2015)... February 26, 2015 The Pittcon ... at the Ernest N. Morial Convention Center in ... as of February 19, 2015) displaying products and ... academic, and government labs. The Exposition will offer ... not limited to, analytical chemistry; drug discovery; nanotechnology; ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Pittcon 2015 Announces Exposition Highlights 2
... in Gastroenterology Panel Discussion, ISELIN, N.J., Dec. 10 ... Chief Executive Officer Elkan R. Gamzu,Ph.D. will participate in ... Healthcare Conference taking place December 12,- 13, 2007 at ... York, New York.,The panel is entitled "Going With Your ...
... Dan Gold, Ph.D., Joins as Chief Executive Officer, ... Applied,Biology, Inc. (FAB), a privately held biotechnology company, ... financing. Prior investor SV Life,Sciences (SVLS) led the ... from the financing will be used to develop ...
... EXTON, Pa., Dec 7 Kensey Nash Corporation,(Nasdaq: ... discussion on,"Helping the Body Regenerate Bone & Tissue" at ... Evans, Kensey Nash,s COO, will participate in the panel,discussion ... The Westin New,York at Times Square in New York. ...
Cached Biology Technology:Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2Fundamental Applied Biology, Inc. Completes $21 Million Series B Financing 2Fundamental Applied Biology, Inc. Completes $21 Million Series B Financing 3
Synaptotagmin, phosphoSer309...
... anti-phospho-IRS1 (Tyr896) ... to amino acid region encompassing ... phospho-IRS1 (Tyr896). ... Quality Assurance: ...
Goat polyclonal to PPP2R5D Immunogen: Peptide with sequence KRAEEFLTASQEAL, from C Terminus of the protein sequence according to NP_006236...
...
Biology Products: