Navigation Links
Worm genes KO'd
Date:4/25/2010

SALT LAKE CITY, April 25, 2010 Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing knockout mice. Kent Golic found a way to cripple fruit fly genes. Now, biologist Erik Jorgensen and colleagues have devised a procedure for knocking out genes in nematode worms.

"We developed a method that allows us to walk through the worm genome and determine the function of each gene, and thereby infer the function of these genes in humans," says Jorgensen, a biology professor, senior author of a new study outlining the technique, and an investigator with the Howard Hughes Medical Institute.

The study shows how a transposon or "jumping gene" can be used to delete specific genes from the 1-millimeter-long nematode worm, Caenorhabditis elegans. It was scheduled for online publication Sunday, April 25 in the journal Nature Methods.

"We are trying to understand how genes work and are regulated, and the easiest way to do that is to use a simple organism," says University of Utah postdoctoral fellow Christian Frkjr-Jensen, the study's first author. "The amazing thing is that cellular processes in a lowly worm are similar to the biology in humans. We've made it much easier and faster to change the genetic blueprint of a simple worm so we can study and understand how genes are regulated."

Jorgensen adds: "We want to know what human genes do because they allow us to do all the wonderful things we do run, speak, live and understand what goes wrong in genetic diseases and how we can possibly treat them."

Capecchi, a distinguished professor of human genetics, shared the 2007 Nobel Prize in Physiology or Medicine with two other researchers who independently developed gene targeting in mice in the 1980s. Golic, a professor of biology, published his key papers on targe
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm genes KO'd
(Date:7/10/2014)... 2014  The American Academy of Forensic Sciences ... and Technology (NIST) and the Department of Justice ... forensic science expert members to the Forensic Science ... of the NIST,s Organization of Scientific Area Committees ... appointments made to the new FSSB that has ...
(Date:7/10/2014)... N.Y. , July 2, 2014 It ... (ABD) to announce the appointment of the world-renowned Thoracic ... Board of Directors. Dr. Ginsburg, with over ... facilities: NY Presbyterian Hospital and Good Samaritan Regional Medical ... Pacemaker since the late 1980,s and is considered an ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... in French . , A new brain-imaging ... reveals that ghrelin - a stomach hormone, acts on specific ... related cues and eating for pleasure. This study, published ... to advance understanding and treating obesity, a condition affecting millions ...
... for increasing the soil organic carbon (SOC) pool must be ... SOC accrual in NT soils have primarily focused on the ... soil profile. The lack of adequate data on the SOC ... NT farming on SOC sequestration and off-setting CO2 emissions. , ...
... Siberian village will discuss their artworks, which are on ... Science (AAAS) Gallery, 1200 New York Ave, NW, Washington, ... old, will describe their works and answer questions from ... 14 May in the AAAS auditorium. The works, mainly ...
Cached Biology News:Hunger hormone: Makes food more attractive 2Finding the real potential of no-till farming for sequestering carbon 2May 14 AAAS Lecture and videoteleconference on artworks by Siberian schoolchildren 2
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
(Date:1/15/2014)... JOLIET, Ill. , Jan. 15, 2014  Bill Jacobs Automotive, ... , is teaming up with the Heartland Blood Center ... annual blood drive. The drive takes place Saturday, Jan. 18 ... a.m. - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
Breaking Biology Technology:University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... Jan. 13 Alseres Pharmaceuticals, Inc. (Nasdaq: ALSE ... into a securities purchase agreement (the "Agreement") with Robert Gipson ... of the Company at a purchase price of $1.00 per ... $1 million. In connection with the Agreement, Mr. Gipson ...
... (TSX: GEN), a company focused on developing blood-based ... and personalized health management, today announced it has ... for the detection of Chagas disease related gene ... discovery of a blood biomarker-based method of testing ...
... Inc. (OTCBB: JMAR), San Diego, CA, a leading innovator in ... of chemical, biological, radiological, nuclear and explosive (CBRNE) materials, today ... which is the only commercialized, EPA tested, online system for ... ...
Cached Biology Technology:Alseres Pharmaceuticals, Inc. Announces $1 Million Financing 2Alseres Pharmaceuticals, Inc. Announces $1 Million Financing 3Alseres Pharmaceuticals, Inc. Announces $1 Million Financing 4GeneNews granted U.S. patent for Chagas disease based on Sentinel Principle(TM) platform 2JMAR Technologies Raises Awareness of BioSentry -- A High Tech Counter to Bioterrorism 2JMAR Technologies Raises Awareness of BioSentry -- A High Tech Counter to Bioterrorism 3JMAR Technologies Raises Awareness of BioSentry -- A High Tech Counter to Bioterrorism 4
... Activated affinity media for spontaneous ligand immobilization can ... antibody, enzyme, antigen, or receptor to create an ... 15 supports couple ligands via primary amines. Affi-Gel ... pI from 6.5 to 11; Affi-Gel 15 gel ...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: