Navigation Links
Tumor suppressor pulls double shift as reprogramming watchdog
Date:8/9/2009

l cells, demonstrating that p53 clearly played an important role in reigning in cells trying to revert back into a stem-like state.

Because iPSCs generated with the full complement of reprogramming factors run the risk to turn malignant, Belmonte and his team wanted to know whether mouse cells lacking p53 could be reprogrammed using only two factors, Oct4 and Sox2. The cells readily converted into iPSCs and gave rise to healthy, full term mice that were able to reproduce passing the ultimate test for pluripotent embryonic stem cells.

"This very successful collaboration is a prime example of what makes the Salk such a special place," says Wahl. "Juan Carlos and I talk every day and we approach the same question from very different perspectives. He comes from a developmental biology perspective, while I come from the cancer side but when put together they can make for a great story."


'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

2

GOOD

Page: 1 2 3

Related biology news :

1. La Jolla Institute discovers novel tumor suppressor
2. Nanoparticle-delivered suicide genes slowed ovarian tumor growth
3. Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
4. Tumor suppressor gene in flies may provide insights for human brain tumors
5. Cancer-causing protein can also help fight the tumors it causes
6. Potential for non-invasive brain tumor treatment
7. Protein linked to change in tissue that surround and support breast tumors
8. Tumor growth and chemo response may be predicted by mathematical model
9. Computer model predicts brain tumor growth and evolution
10. From cars to cancer: UH professor employs auto industry tools for tumor therapy
11. Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tumor suppressor pulls double shift as reprogramming watchdog
Tumor suppressor pulls double shift as reprogramming watchdog
(Date:11/20/2009)...arch report published in the November 2009 issue o... ), scientists show how a family of genes (1-amino... are responsible for production of ethylene. This ... this information lays the foundation for future g... resistant, able to survive and thrive in difficul...
(Date:11/20/2009)...ago, a group of University of Oklahoma researchers...t of the human genome project. Today, the OU Adv... to an international effort to sequence the tomato...ational Science Foundation for plant genomics. , ...e, so improving the tomato and crop yields will im...
(Date:11/20/2009)...question in the origin of biological molecules lik...ions of years ago from simple precursors. Now, in ...in Italy have reconstructed one of the earliest ev...A from individual subunits using nothing but warm ...one of the first biological molecules present, bef...
Breaking Biology News(10 mins):It's a gas: New discovery may lead to heartier, high-yielding plants 2NSF awards $7.5M grant to University of Oklahoma for plant genomics 21 in 7 Low Income Preschoolers Is Obese 52597 11 in 7 Low Income Preschoolers Is Obese 52597 2UC San Diegos 243 million NSF grant to fund science festivals 9336 1UC San Diegos 243 million NSF grant to fund science festivals 9336 2UC San Diegos 243 million NSF grant to fund science festivals 9336 3Registered Dietitian Reveals Chronic Back Pain Relief through Diet in New Book Cookbook and Diet Program 52595 1Registered Dietitian Reveals Chronic Back Pain Relief through Diet in New Book Cookbook and Diet Program 52595 2
...ension increases blood pressure by activating tiny...creased levels of sodium to be reabsorbed into the...ter have found. The findings shed light on the und...y also help explain why patients with hypertension...m supplements in order to keep their high blood pr...
... first detailed molecular images of a piece of the...grab host cells and initiate the first stages of i... protein grasps its receptor, may help scientists ...s. The information could also be helpful in identi...by novel antiviral drugs or vaccines. , The SARS ...
...arley could lead to improved varieties of the crop...d beer. Scientists funded in part by the Biotechno...RC) are beginning a new programme to uncover key g...different barley varieties. , The research, being ...e, Birmingham University and NIAB, involves almost...
Other Biology News:Enzyme affects hypertension by controlling salt levels in body 2Enzyme affects hypertension by controlling salt levels in body 3Learning how SARS spikes its quarry 2Learning how SARS spikes its quarry 3Whisky fans can drink to crop research 2
(Date:11/19/2009)..., COPENHAGEN, Nov. 19 Danish Pri...n cellulosic ethanol plant in Kalundborg, Denmark,... the world,s first and largest 2nd generation etha...erase enzymes are used in the plant,s innovative p...ivision of Danisco, was the first to market with c...
(Date:11/19/2009)..., BETHESDA, Md., Nov. 19 /PRNewswire-FirstCall/...vator in biotechnology for diabetes therapy, and a...ervices to food, supplement, biotechnology and pha... of Tuesday,s Annual Meeting of Shareholders. ,...ated (Nasdaq: SPEX ) elected the following member...
(Date:11/19/2009)... World,s Top Gene Synthesis Com...m (IGSC) to Coordinate Best Practices in Risk Redu...t of Worldwide Gene Synthesis Capacity , ...of the world’s leading gene synthesis compan... a common screening protocol to promote biosecurit...
(Date:11/18/2009)...Security personnel need to be able to find explosi...with them. To aid such searches, the National Inst...port from the Department of Homeland Security, has...ndard Reference Material (SRM) 2905, Trace Particu...ory assay methods, the SRM will be helpful in cali...
Breaking Biology Technology:DONG Energy and Inbicon Inaugurate One of the World's Largest Demo Plants for 2nd Generation Biofuel 2Spherix Announces Results of Annual Shareholders Meeting 2Spherix Announces Results of Annual Shareholders Meeting 3Spherix Announces Results of Annual Shareholders Meeting 4World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 2World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 3World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 4New NIST trace explosives standard slated for homeland security duty 2
... Beam Shaping Device Optimized for Targeting Tumor...actic Radiotherapy and Radiosurgery, PALO ALTO, C...E: VAR ) has received FDA 510(k) clearance for a ... ultra-fine beam shaping,device for radiosurgery. ...inicians to deliver,extremely precise radiosurgica...
...ses Research Effort to Target Drug-Resistant Gram ... PHILADELPHIA, Sept. 18 GlaxoSmithKline (NYSE:,GS... with the Defense,Threat Reduction Agency (DTRA) o...y and develop a new class of antibacterials target... Gram negative hospital pathogens. The,agreement a...
...IA, Sept. 18 Premier Research Group plc (AIM:,PRG...its Vice President,Global Human Resources. Mr. Kee...direction and implementing activities related to m...people and organization in alignment,with the comp...mmented: "We are very pleased to have someone,of S...
Other Biology Technology:Varian Medical Systems Receives FDA 510(k) Clearance for High-Definition Collimator That Enables Ultra-Fine Intensity-Modulated Radiosurgery 2Varian Medical Systems Receives FDA 510(k) Clearance for High-Definition Collimator That Enables Ultra-Fine Intensity-Modulated Radiosurgery 3GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 2GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 3Premier Research Appoints Global Head of Human Resources 2
OmniSlide thermal Cycler from Thermo Scientific
...ytopathic effect inhibition assays, also known as ...issue culture supernatents; serum from PK studies ...nit is defined as the quantity of interferon requi... of viral infection by 50%. All standards used i...
T4 DNA Polymerase from New England Biolabs
[14C(U)]-L-Amino Acid Mixture, 250Ci (9.25MBq) from PerkinElmer
Biology Products: