The vasculature emerges as a potential therapeutic target in treating ADPKD l...(as they grow out from the liver. In vitr...)

Date:9/23/2009

as they grow out from the liver. In vitro studies demonstrate that angiogenic factors secreted by the liver cyst wall epithelium, including VEGF-A and IL-8, can drive angiogenic development of human endothelial cells. This development is blocked by inhibition of VEGF receptor signaling. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The article by Brodsky and colleagues provides the important insight that the liver cyst walls maintain a vasculature as they grow out from the liver and that VEGF receptor signaling plays a key role in inducing angiogenesis. These multidisciplinary studies lay a framework for the development of new therapies aimed at preventing the growth of liver cysts in patients with ADPKD".

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Contact: Dr. R. Brian Doctor brian.doctor@ucdenver.edu 303-724-7224 Society for Experimental Biology and Medicine Source:Eurekalert

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