Navigation Links
Sandia and UNM lead effort to destroy cancers
Date:4/18/2011

ALBUQUERQUE, N.M. Melding nanotechnology and medical research, Sandia National Laboratories, the University of New Mexico, and the UNM Cancer Research and Treatment Center have produced an effective strategy that uses nanoparticles to blast cancerous cells with a mlange of killer drugs.

In the cover article of the May issue of Nature Materials, available online April 17 , the researchers describe silica nanoparticles about 150 nanometers in diameter as honeycombed with cavities that can store large amounts and varieties of drugs.

"The enormous capacity of the nanoporous core, with its high surface area, combined with the improved targeting of an encapsulating lipid bilayer [called a liposome], permit a single 'protocell' loaded with a drug cocktail to kill a drug-resistant cancer cell," says Sandia researcher and UNM professor Jeff Brinker, the principal investigator. "That's a millionfold increase in efficiency over comparable methods employing liposomes alone without nanoparticles as drug carriers."

The nanoparticles and the surrounding cell-like membranes formed from liposomes together become the combination referred to as a protocell: the membrane seals in the deadly cargo and is modified with molecules (peptides) that bind specifically to receptors overexpressed on the cancer cell's surface. (Too many receptors is one signal the cell is cancererous.) The nanoparticles provide stability to the supported membrane and contain and release the therapeutic cargo within the cell.

A current Food and Drug Administration-approved nanoparticle delivery strategy is to use liposomes themselves to contain and deliver the cargo. In a head-to-head comparison of targeted liposomes and protocells with identical membrane and peptide compositions, Brinker and colleagues report that the greater cargo capacity, stability and targeting efficacy of protocells leads to many times greater cytotoxicity [destruction] directed specifically to
'/>"/>

Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Biofuel chemistry more complex than petroleum, say Sandia and Lawrence Livermore researchers
2. Sandia wins 2 national technology transfer awards for work with Cray, Stirling Energy Systems
3. Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel
4. Stopping MRSA before it becomes dangerous is possible, Sandia/UNM researchers find
5. Salt block unexpectedly stretches in Sandia experiments
6. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
7. San Diego Zoo Global joins effort to conserve the Amazonian rain forest through Peru field station
8. Unique frog helps amphibian conservation efforts
9. Plenary speech by HHMI professor highlights efforts of scientist-educators
10. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
11. Teacher effort is linked to difficult students inherited traits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... Lung Screening Trial (NLST) investigators also conclude that ... with low-dose computed tomography (LDCT) versus chest X-ray ... paper is achievable at experienced screening centers in ... information to share with their patients about the ... following today,s publication in the New England ...
(Date:5/22/2013)... can detect molecular variants in chemical mixtures greatly ... important, though time-consuming, processes in analytical chemistry. , ... post-doctoral researcher David Patterson, Professor of Physics John Doyle ... Laser Science (CFEL) in Hamburg, Germany developed a system ... variants apart, and to determine how much variant is ...
(Date:5/22/2013)... fatty acids in fish oil have long been thought ... American Heart Association currently recommends eating at least two ... in omega 3s. However, the mechanism behind this protective ... scientists led by Jason R. Carter of Michigan Technological ... that fish oil might specifically counteract the detrimental effects ...
Breaking Biology News(10 mins):NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 2NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 3Detecting mirror molecules 2Detecting mirror molecules 3Fish oil may help the heart beat mental stress 2
... living in the deep sea, it seems that there is ... it,s generally best to be transparent. But in the deeper ... as searchlights, it,s much better to go in darker colors. ... 10 in Current Biology , a Cell Press publication. ...
... 10, 2011 ─ (BRONX, NY) ─ Researchers at then ... Yeshiva University have uncovered a mechanism that governs how ... implications for human health and disease and appear in ... Cell . A fundamental question in biology ...
... weed that clogs waterways around the world has at least ... for boats and submarines. The Brazilian fern Salvinia ... part because its surface is dotted with oddly shaped hairs ... afloat. In the November 1 issue of the ...
Cached Biology News:For deep-sea cephalopods, 'switchable' camouflage saves the day 2Einstein researchers discover key to cell specialization 2Plant with 'eggbeater' testure inspires waterproof coating 2Plant with 'eggbeater' testure inspires waterproof coating 3
(Date:5/21/2013)... , May 21, 2013  On May ... FCN ), the global business advisory firm dedicated ... value (the "Company"), announced that it has combined ... were formerly included within the Corporate Finance/Restructuring segment ... segment to form a single integrated practice whose ...
(Date:5/21/2013)... 2013 Alpha Source, Inc., a ... be exhibiting for the 13th consecutive year at ... (AAMI) 2013 Conference and Expo. The conference brings ... manufacture healthcare technologies. This year’s event will be ... , The three-day event draws over 1,500 ...
(Date:5/21/2013)... ALBANY, New York , May 21, 2013 /PRNewswire/ ... published by Transparency Market Research ( http://www.transparencymarketresearch.com ) "Biochip ... Science Research, IVD Tests) - U.S. Industry Analysis, Size, Share, ... USD 2.4 billion in 2011 and is expected to ... 2018, to reach an estimated value of USD 4.7 ...
(Date:5/21/2013)... 21, 2013  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... serious infectious diseases, announced today that Jeffrey Riley ... Annual Marcum LLP MicroCap Conference on Thursday, May 30, 2013 ... Grand Hyatt Hotel. Mr. Riley is scheduled to present at ... Synthetic Biologics, presentation can be accessed by logging onto the ...
Breaking Biology Technology:FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2Alpha Source, Inc. to Exhibit at the AAMI 2013 Conference and Expo 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5Synthetic Biologics to Present at the 2nd Annual Marcum LLP MicroCap Conference 2
... the more difficult challenges in business is turning around a ... and the company is forced into bankruptcy. Realizing the painful ... or impossible for owners and senior executives to deal with ... save them, and they will close that big outstanding proposal, ...
... escalate at a double-digit pace in 2003, but there are ... next year, according to global HR outsourcing and consulting firm ... 12.6 percent average increase for employers, which is lower than ... to absorb the majority of next year's increase, but many ...
... business conditions provide a golden opportunity to tune your ... appear to have calmed, the long-term winners will be ... winning strategies. Real competitive advantage comes from making ... fundamentally aligning your talent management practice to that choice, ...
Cached Biology Technology:Turning Around a Sick Company 2Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004 2Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004 3Talent Constellations or Talent Communities Choosing the Right Talent 2Talent Constellations or Talent Communities Choosing the Right Talent 3
... Red, 20X Immunogen ... 20X concentration for use in KinEASE™ ... Quality Assurance Routinely ... polarization assays. Stability ...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Rabbit anti-NFkB p105/p50 (Ser337) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Biology Products: