Navigation Links
rAAV/ABAD-DP-6His attenuates oxidative stress induced injury of PC12 cells
Date:5/7/2014

The effects of Amyloid beta (Aβ)-Aβ-binding alcohol dehydrogenase (ABAD) may exacerbate Alzheimer's disease pathology. Therefore, blocking Aβ-ABAD-mediate effects with ABAD decoy peptide (ABAD-DP) may be a potential therapeutic strategy for Alzheimer's disease. Dr. Jiang Wu and team from the First Hospital of Jilin University in China successfully constructed a recombinant adenovirus constitutively secreting and expressing Aβ-ABAD decoy peptide (rAAV/ABAD-DP-6His). Their results showed that rAAV/ABAD-DP-6His increased superoxide dismutase activity in hydrogen peroxide-induced oxidative stress-mediated injury of PC12 cells. Moreover, rAAV/ABADDP-6His decreased malondialdehyde content, intracellular Ca2+ concentration, and the level of reactive oxygen species. rAAV/ABAD-DP-6His maintained the stability of the mitochondrial membrane potential. In addition, the ATP level remained constant, and apoptosis was reduced. Overall, the experimental findings, published in the Neural Regeneration Research (Vol. 9, No. 5, 2014), indicate that rAAV/ABAD-DP-6His generates the fusion peptide, Aβ-ABAD decoy peptide, which effectively protects PC12 cells from oxidative stress injury induced by hydrogen peroxide, thus exerting neuroprotective effects.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Oxidative stress, mitochondrial damage and neurodegenerative diseases
2. Oxidative stress and altered gene expression occurs in a metabolic liver disease model
3. Red hair is a sign of oxidative stress in wild boars, but gray is a-ok
4. Your stress is my stress
5. Chronic stress heightens vulnerability to diet-related metabolic risk
6. Its not all wedded bliss: Marital stress linked to depression
7. Horsing around reduces stress hormones in youth
8. For cells, internal stress leads to unique shapes
9. Neurobiologists find chronic stress in early life causes anxiety, aggression in adulthood
10. Study: Stress impacts ability to get pregnant
11. Study in mice raises question: Could PTSD involve immune response to stress?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
rAAV/ABAD-DP-6His attenuates oxidative stress induced injury of PC12 cells
(Date:3/11/2016)... , March 11, 2016 http://www.apimages.com ) ... Cross reference: Picture is available at AP Images ( http://www.apimages.com ) ... DERMALOG will be used to produce the new refugee identity cards. ... biometric innovations, at CeBIT in Hanover next ... from DERMALOG will be used to produce the new refugee identity ...
(Date:3/10/2016)... BELL, Pa. , March 10, 2016   Unisys ... U.S. Customs and Border Protection (CBP) is testing its ... San Diego to help identify certain ... States . The test, designed to help determine the ... pedestrian environment, began in February and will run until May ...
(Date:3/9/2016)... Fla. , March 9, 2016  Crossmatch ... authentication and enrollment solutions, today announced the addition ... ® Altus multi-factor authentication platform. New ... InfoSec managers to step-up security where it,s needed ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 05, 2016 , ... CereScan, ... the National Stroke Association during National Stroke Awareness Month in May. An ... pages throughout the month. CereScan will donate $1 up to a maximum ...
(Date:5/4/2016)... ... ... Proove Biosciences, Inc. , the commercial and research leader in personalized pain ... partnership is designed to advance research in pain genetics in an effort to bring ... new agreement, researchers at Proove Biosciences are able to collaborate with Luda Diatechnko, MD, ...
(Date:5/4/2016)... ... , ... The Children’s Tumor Foundation announced its annual month-long campaign to raise ... throughout the body. It affects 1 in 3,000 people of all populations; there is ... of May, as well as online activities, Neurofibromatosis Awareness Month and “I Know a ...
(Date:5/4/2016)... Kansas City, Missouri (PRWEB) , ... May 04, 2016 , ... ... President of Professional and Agricultural Sales. , Doug began his career at PBI-Gordon ... has since served in a wide variety of roles, ranging from customer service to ...
Breaking Biology Technology: