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Princeton team learns why some drugs pack such a punch
Date:8/20/2009

tsH protease. Under normal circumstances, the FtsH protease chops up the jammed translocators, contributing to cell death.

The scientists found, however, that when they increased the amount of YccA, a protein that is present in the bacterial cell, YccA proteins protected the translocators from the FtsH attackers. YccA, it turns out, is very similar to a human protein known as Bax Inhibitor-1 (BI-1) that is of great interest to cancer researchers because cancer proliferates when it malfunctions.

"We have determined how YccA works in preventing stress-induced death in bacteria," van Stelten said. "We hope this new information will shed light on the mechanism of BI-1 in humans."


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Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

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Princeton team learns why some drugs pack such a punch
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