Navigation Links
Penn study shows 2-sided immune cell could be harnessed to shrink tumors
Date:10/28/2010

e closer to the clinic, the team also demonstrated that Th17 cells cannot only be expanded to large numbers, but could also be maintained by stimulating them with ICOS proteins. Th17 polarizing cytokines have previously been shown to support Th17 cells from nave CD4 cells but this is the first demonstration that the ICOS costimulatory molecule used to expand the Th17 cells is important.

Tilting the balance between spurring and suppressing the growth of Th17 cells may be a key to tailoring immunotherapy, a form of cancer treatment. Adoptive transfer of tumor-specific cells expanded with ICOS and polarized to a Th17 cell type might further improve treatment.

These basic findings on Th17 cells in both peripheral and cord blood cells has broad implications, providing the basis of a new human cancer treatment protocol. T-cell-based therapies that incorporate the ICOS signal are being planned at Penn to treat patients with leukemia.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Texas A&M University becomes key player in global study to save Earths endangered species
2. Study suggests a third of shark and ray species are threatened
3. Study identifies key molecules in multiple myeloma
4. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
5. Penn study identifies molecular guardian of cells RNA
6. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
7. Offshore wind a mixed bag: University of Maryland study
8. Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington
9. Universities receive grants to study climate change decisions
10. Center to study effects of plastics chemicals on childrens health
11. Study of tiny magnets may advance their use in microelectronics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study shows 2-sided immune cell could be harnessed to shrink tumors
(Date:5/16/2013)... have used ancient shorelines to predict the stability of today,s ... high shoreline from three million years ago, for example ... thought to be evidence of a high sea level due ... led many scientists to think that if the world,s largest ... just the same in our modern, progressively warming world. ...
(Date:5/16/2013)... choose to wear the color red when they compete? ... Science , a journal of the Association for Psychological ... their testosterone levels. , The new study, conducted by ... and colleagues, demonstrated that males who chose red as ... levels than other males who chose blue. , "The ...
(Date:5/16/2013)... the entirety of an individual,s DNA is examined to ... cause health problems is a massively useful technology for ... ethical problems if used incorrectly, say new recommendations from ... line today (16 May 2013) in the European ... whole genome and on exome* sequencing and analysis are ...
Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2High-testosterone competitors more likely to choose red 2European Society of Human Genetics urges caution over use of new genetic sequencing techniques 2
... of Health has awarded $4 million to a group ... Natural Sciences, to aid in the discovery of new ... in the Philippines. , Research will be concentrated in ... estimated 10,000 marine mollusk speciesabout a fifth of all ...
... to introduce plant-eating predators to fight a superweed spreading ... bullet, says a world expert on Japanese knotweed at ... the Department of Biology has been researching the invasive ... students Michelle Hollingsworth and Catherine Pashley. Research ...
... controlled trial called the "Evaluate the Clinical use of ... trial, Angela Cheung and colleagues at the University of ... supplement did not protect against age-related bone mineral density ... PLoS Medicine , the findings also suggest that vitamin ...
Cached Biology News:Academy participates in project to discover drugs, biofuels in tropical seas 2'Plant-eating predator to fight superweed is not magic bullet' 2
(Date:5/16/2013)... May 16, 2013 Kitware ... solutions, today announces new Phase II SBIR funding ... continued development of an open-source, high performance computing ... integration framework enables researchers to select only the ... of simulation, computation, or analysis tasks. , ...
(Date:5/16/2013)... SAN DIEGO , May 16, 2013  The ... the Association of Bioscience Financial Officers (ABFO) 2013 National Conference, ... will be held May 28-31 at the Hilton San ... finishing touches on this year,s conference and want to ... opportunity to attend," said Brandi Roberts ...
(Date:5/16/2013)... (PRWEB) May 16, 2013 As the weather ... showcase their favorite Spring looks. While most make a statement ... Unfortunately, many women find the warmer weather mixes makeup and ... cope with the onset of acne during warmer months, ... female acne treatment users the best ways to deter breakouts. ...
(Date:5/16/2013)... NEW YORK , May 16, ... a new market research report is ...   Competitor Analysis: ... Biosuperiors http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical ...   The ...
Breaking Biology Technology:Kitware Develops a Customizable Simulation Framework to Provide HPC for Small to Mid-Sized Manufacturers 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 3Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 4Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8
... SEATTLE, April 12, 2011 EMC Corporation (NYSE: ... solutions, today announced that Sanford-Burnham Medical Research Institute , ... Institutes of Health (NIH) grant funding and among the top ... EMC Isilon® scale-out NAS as the primary ...
... 2011 Reportlinker.com announces that a new market research ... Biomarker Partnering Terms and Agreements ... The Biomarker Partnering Terms and Agreements report provides comprehensive ... and agreements entered into by the worlds leading healthcare ...
... holds intriguing possibilities for the future of industrial ... green energy technologies as artificial photosynthesis, researchers with ... National Laboratory (Berkeley Lab) have created bilayered nanocrystals ... to feature multiple catalytic sites on nanocrystal interfaces. ...
Cached Biology Technology:Sanford-Burnham Turns Big Data Into Scientific Breakthroughs With EMC Isilon 2Sanford-Burnham Turns Big Data Into Scientific Breakthroughs With EMC Isilon 3Reportlinker Adds Biomarker Partnering Terms and Agreements 2Reportlinker Adds Biomarker Partnering Terms and Agreements 3Reportlinker Adds Biomarker Partnering Terms and Agreements 4Reportlinker Adds Biomarker Partnering Terms and Agreements 5Reportlinker Adds Biomarker Partnering Terms and Agreements 6Reportlinker Adds Biomarker Partnering Terms and Agreements 7Reportlinker Adds Biomarker Partnering Terms and Agreements 8Berkeley Lab researchers report tandem catalysis in nanocrystal interfaces 2Berkeley Lab researchers report tandem catalysis in nanocrystal interfaces 3