Penn study shows 2-sided immune cell could be harnessed to shr... ( PHILADELPHIA

Penn study shows 2-sided immune cell could be harnessed to shrink tumors

Date:10/28/2010

PHILADELPHIA - A recently identified immune cell that directs other cells to fight infection plays a critical role in regulating the immune system in both health and disease. Researchers from the University of Pennsylvania School of Medicine have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make T helper 17 cells multi-taskers of sorts. Th17 cells protect the body against infection and cancer, but are also culprits in some autoimmune diseases and out-of-control, cancerous cell growth.

This new understanding that Th17 cells manage to play both sides of the fence suggests that targeting or inhibiting the involved protein pathways might be a new way to treat cancer, chronic infection, and some autoimmune diseases. Previous studies have linked excessive amounts of Th17 cells in the body to such autoimmune diseases as multiple sclerosis, psoriasis, rheumatoid arthritis, and Crohn's disease.

First author and postdoctoral fellow Chrystal Paulos PhD; senior author Carl June, MD, professor of Pathology and Laboratory Medicine, and colleagues have found that a protein called inducible costimulator (ICOS) is necessary for the growth and function of human Th17 cells, while CD28, a transmembrane protein on CD4 cells, stops the ICOS signal. What's more, human Th17 stimulated with ICOS shrank human tumors implanted in a mouse model faster than those stimulated with CD28. The findings appear in this week's Science Translational Medicine. June is also the Program Director of Translational Research for the Abramson Family Cancer Research Institute at Penn.

These findings were surprising to the researchers given that CD28 has historically been used by investigators to study and expand human Th17 cells. The new data on Th17 cells raises the possibility that the full inflammatory potential of human Th17 cells had not been fully reflected by previous lab studies.

To move this knowledg
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2
Related biology news :

1. Texas A&M University becomes key player in global study to save Earths endangered species
2. Study suggests a third of shark and ray species are threatened
3. Study identifies key molecules in multiple myeloma
4. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
5. Penn study identifies molecular guardian of cells RNA
6. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
7. Offshore wind a mixed bag: University of Maryland study
8. Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington
9. Universities receive grants to study climate change decisions
10. Center to study effects of plastics chemicals on childrens health
11. Study of tiny magnets may advance their use in microelectronics

Post Your Comments:

Related Image:

Penn study shows 2-sided immune cell could be harnessed to shrink tumors

(Date:6/19/2013)... -- New York College of Health Professions announces the publishing ... Office for detecting biometric changes through smart phones, apps ... injured, attacked or killed. This patent is ... Agreements of New York College of Health Professions. ... New York College says, "Our Chairman, ...

(Date:6/19/2013)... expected to contribute to a very large and potentially ... a University of Michigan ecologist and colleagues who released ... Chesapeake Bay. , The Gulf forecast, one of two ... for an oxygen-depleted, or hypoxic, region of between 7,286 ... the 10 largest on record. , The low end ...

(Date:6/19/2013)... provider of scientific, technical and medical information products and ... new open access journal, GeoResJ . , ... and planetary science journals portfolio has its first open ... forum for rapid publication of top research within the ... by six Executive Editors, each covering a different discipline, ...

Breaking Biology News(10 mins):New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 2 New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 3 New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 4 U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 2 U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 3 U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 4

[0] New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed [0] U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone'[0] Elsevier launches open access journal: GeoResJ

... into the atmosphere by power plants and agricultural activities plays ... a global scale, but the impact is greatly amplified in ... research by atmospheric and marine chemists. Ocean acidification ... nitrogen mix with seawater, a process which lowers the pH ...

... an enzyme down a new evolutionary pathway, a team ... form of an enzyme capable of producing a range ... properties. Writing in the current issue (Sept. 9, ... of researchers from the UW-Madison School of Pharmacy describes ...

... the great flood of Noahs generation really occur thousands of ... an ancient tsunami" Will pollution levels in our deep seas ... few of the questions that are being addressed by a ... the non-profit research and education organization, EcoOcean. The ...

Cached Biology News:Acid rain has a disproportionate impact on coastal waters 2 Acid rain has a disproportionate impact on coastal waters 3 Using evolution, UW team creates a template for many new therapeutic agents 2 TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 2 TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 3

Acid rain has a disproportionate impact on coastal waters Using evolution, UW team creates a template for many new therapeutic agents TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship

(Date:6/19/2013)... Biotechnology industry pioneer Amgen (NASDAQ: ... BlackLine Systems and enterprise application software leader ... webinar next week entitled "No Account Left Behind! ... to Help Keep Its Account Reconciliations in Good Shape ... The webinar, geared at finance, accounting, audit and compliance ...

(Date:6/19/2013)... Toronto, Canada (PRWEB) June 19, 2013 ... clinical trial business can potentially be worth up ... With this opportunity, the Indian government is taking ... clinical trials the process. , This presentation will ... clinical trial regulations , Immediate and long ...

(Date:6/19/2013)... MN (PRWEB) June 19, 2013 Express ... abuse tests, today announced that it has received Class ... market and sell its DrugCheck® NxStep Onsite Drug ... use of the rapid screening device in near-patient settings, ... Drug Screen Cup received Health Canada Class III approval ...

(Date:6/18/2013)... 2013) A million electric cars could be on roads ... the help of research by the United States Department of ... , Professor Zhongwei Chen is part of a team led ... materials to replace the expensive platinum catalysts in fuel cells. ... fuel cells in vehicles is the cost of the units. ...

Breaking Biology Technology:Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 2 Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 3 Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 4 Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 2 Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 3 US and Canadian researchers drive towards cheaper fuel cells for electric cars 2

[0] Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations [0] Navigating the Dynamic Indian Clinical Trial Landscape, New Webinar Hosted by Xtalks [0] Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval [0] US and Canadian researchers drive towards cheaper fuel cells for electric cars

... , Evelyn McGown, Ph.D. , Molecular Devices Corporation. ... introduced SPECTRAmax , the first microplate reader equipped ... selection. It was also the first microplate reader capable ... transformed the microplate reader from a limited colorimetric filterbased ...

... , , ... Protein concentration is commonly estimated by measuring the ... extinction coefficient of the protein. The procedure is feasible because ... fixed 1 cm pathlength. Extinction-based protein assays can also be ...

... INTRODUCTION ... either plasmid or chromosomally encoded bacterial enzymes which hydrolyze β -lactam ... serine active site enzymes. One successful approach to combating the serine ... such as clavulanic acid, in combination with a β -lactam antibiotic ...

UV Absorbance Measurements in SpectraMax Microplate Spectrophotometers MaxLine Application Note #32)PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26)A Microtiter-based Assay for the Determination of ID50s of b-lactamase Inhibitors Employing Reporter Substrates Detected at UV or Visible Wavelengths (MaxLine Application Note #20)

... high performance miniature stepper motors available in ... frame sizes. These space-efficient 1.8 2-phase stepper ... including medical instrumentation, medical devices, drug discovery ... Meets a wide range of customer needs ...

... nitrogen base (YNB) is a base medium for ... YNB contains ammonium sulfate but does not contain ... are available. Each pouch contains reagents to ... media or 1000 ml of 10X YNB for ...

... description: Designed for use with dishes and ... is a new product number, created to ... no availability yet, please order under the ... service for assistance. Comp Dim: blade L ...

... (Catalog number SCR004) is a specific and ... ES cell differentiation by the determination of ... are the monoclonal antibodies TRA-2-49 (Catalog Number ... permit the detection of Liver / Bone ...

Biology Products:

LV Series Miniature Stepper Motors from Parker Hannifin Corporation Yeast Nitrogen Base from Invitrogen CORNING CELL LIFTER,STERILE from Sigma-Aldrich Alkaline Phosphatase Detection Kit from CHEMICON