Navigation Links
miR loss may power maligant transformation in chronic leukemia
Date:7/5/2012

COLUMBUS, Ohio Loss of a particular microRNA in chronic lymphocytic leukemia shuts down normal cell metabolism and turns up alternative mechanisms that enable cancer cells to produce the energy and build the molecules they need to proliferate and invade neighboring tissue.

The findings come from a new study led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

The study shows that microRNA-125b (miR-125b) by itself regulates many enzymes and other molecules that allow cells to make building blocks needed for their growth and proliferation such as DNA and lipids needed for cell membranes.

It also shows that miR-125b is often lost in chronic lymphocytic leukemia (CLL), and that the loss is associated with higher rates of glucose metabolism. This is a characteristic of cancer cells called the Warburg effect, and it alters how cancer cells use sugar (glucose) to generate energy. This finding suggests that loss of miR-125b is an early step in CLL development.

The findings, published in the journal Blood, provide a more comprehensive understanding of how cancer develops and identifies new potential targets for CLL drug development, the researchers say.

"Our findings indicate that miR-125b is downregulated in both aggressive and indolent forms of CLL, and that this downregulation is associated with metabolic adaptation to cancer transformation," says principal investigator and corresponding author Dr. Carlo Croce, director of Ohio State's Human Cancer Genetics program and a member of the OSUCCC James Molecular Biology and Cancer Genetics program.

"By identifying the metabolites that are changed, as we have here, we can propose to use drugs that target them and perhaps control the leukemia," Croce says.

Scientists have known for some time that, as normal cells become cancer cells, different metabolic pathways are switch
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Polar And LOOK Launch The Worlds First Pedal-Based Power Cycling System
2. NTUs new loo turns poo into power
3. Pitcher plant uses power of the rain to trap prey
4. UTMB researchers create powerful new method to analyze genetic data
5. Powerful new approach to attack flu virus
6. New study discovers powerful function of single protein that controls neurotransmission
7. Folding light: Wrinkles and twists boost power from solar panels
8. The power of broccoli, in a capsule
9. Powerful sequencing technology decodes DNA folding pattern
10. Green Oakley Cluster to double OSC computing power
11. MIT research: The power of being heard
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... (November 4, 2014) — Think about the way our ... do neighboring cells know that they are supposed to ... do these tissues find the correct place and alignment? ... these crucial questions. , In a new study, UM ... communicate with their surrounding neighbors, at the head-trunk region. ...
(Date:11/4/2014)... OXFORD, England , November 4, 2014 ... expansion and vertical market growth   Fuel3D ... it has closed a funding round totaling $6.4 million (£4 ... (£1.6 million) funding secured earlier this year and paves the ... product in 2015. The funding round was led ...
(Date:11/4/2014)... 4, 2014   Neurotechnology , a provider ... the latest version of its fingerprint matching algorithm ... MINEX evaluation organized by NIST. The MINEX ... the INCITS 378 fingerprint standard template format. MINEX ... tenders in the United States ...
Breaking Biology News(10 mins):The inside story: How the brain and skull stay together 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... about Australian landscapes will soon be only a ... and non-profit sectors thanks to a partnership between ... to CSIRO Principal Research Scientist Dr Alex Held, ... AusCover facility, the partnership aims to provide greater ...
... it remains a mystery why the cerebral pressure in certain ... blood circulation is disrupted and after a while parts of ... a stroke. This is how dementia takes its insidious path. ... of dementia in Europe can be attributed to rising blood ...
... includes a University of California, Davis, plant scientist has identified a ... past and future global change. While earlier studies have found ... carbon sink, or storage, the new study published this week in ... found that part of that sink is only temporary. "It,s ...
Cached Biology News:Scientists and Google to keep an eye on environment 2Pressure switch inside the head 2Carbon buried in the soil rises again 2
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
(Date:11/18/2014)... pH measurement and control is vital in a ... food and beverage industries. But what exactly is pH, ... sensors work? METTLER TOLEDO has produced a guide to ... these questions and more. , METTLER TOLEDO provides a ... The actual sensor, the pH electrode, is therefore the ...
(Date:11/18/2014)... American Process Inc. (Atlanta, GA) and ... with researchers at Georgia Institute of Technology, Clark ... USDA’s Forest Products Laboratory to develop ultra-strong, lightweight ... a rapidly emerging high performance nanomaterial extracted from ... replace heavy steel structures within cars, such as ...
(Date:11/18/2014)... Philadelphia, PA (PRWEB) November 18, 2014 ... healthcare planning and design expertise to the nation's hospitals ... is best served by those dedicating their careers to ... As a respected contributor in her respective field, Laura ... engineering expertise at the 2014 Winter Simulation Conference. ...
Breaking Biology Technology:Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2
... PARIS, April 30 ExonHit Therapeutics S.A.,(Alternext: ALEHT), ... its Supervisory Board., Following the annual shareholders, ... 25th, 2008, Mr. Edmund Olivier de Vezin,s appointment ... of the Board, expired,as he has reached the ...
... ONXX ) today announced that it will webcast ... and provide a general business overview on Tuesday, May ... Time). Financial results for the,first quarter ended March 31, ... parties may access a live webcast of the presentation ...
... (Nasdaq: ALGN ) today announced that its board ... to $50 million, effective,immediately., "We are confident in ... to grow the business," said Ken Arola, vice president ... cash to our,shareholders through a repurchase program will contribute ...
Cached Biology Technology:Frederic Desdouits Appointed Member of the Supervisory Board of ExonHit Therapeutics 2Frederic Desdouits Appointed Member of the Supervisory Board of ExonHit Therapeutics 3Align Technology Announces $50 Million Stock Repurchase Program 2Align Technology Announces $50 Million Stock Repurchase Program 3
... 3F10B10. Immunogen: Synthetic peptide ... of JAB1 (Jun activation domain-binding ... Specific for the JAB1 protein. ... 293T Jurkat cell lysates). ...
Ready-to-use solution....
...
... Production Conjugated peptides or recombinant ... protocol to produce antibodies in 2 rabbits. ... ELISA test until the titer reaches 1:4,000 ... titer Protein G purification Antibodies are ...
Biology Products: