Navigation Links
lobSTR algorithm rolls DNA fingerprinting into 21st century
Date:4/27/2012

before, and those can be used in medical genetics, population genetics, and forensics."

To create a DNA fingerprint, lobSTR first scans an entire genome to identify all STRs and what nucleotide pattern is repeated within those stretches of DNA. Then, lobSTR notes the non-repeating sequences flanking either end of the STRs. These sequences anchor each STR's location within the genome and determine the number of repeats at the STRs. Finally, lobSTR removes any "noise" to produce an accurate description of the STRs' configuration.

According to Melissa Gymrek, who is the first author of the Genome Research paper, lobSTR's ability to accurately and efficiently describe thousands of STRs in one genome has opened up many new research opportunities.

"The first and simple next step is to characterize the amount of STR variation in individuals and populations," says Gymrek, who was an undergraduate researcher in Erlich's lab when she worked on lobSTR. "This will provide knowledge of the normal range of STR alleles at each locus, which will be useful in medical genetics studies that would like to determine if a given allele is normal or likely to be pathogenic. Another direction we are looking at is to look at STRs in case/control studies to look for STRs associated with disease. The list goes on, but these are some of the first questions we're looking to tackle."


'/>"/>

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Researchers develop optimal algorithm for determining focus error in eyes and cameras
2. UT researchers develop algorithm to improve remote electrocardiography
3. MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence
4. MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence
5. Scientists use computer algorithms to develop seasonal flu vaccines
6. Hoyos Corporation Rolls Out First Iris-Biometrics System Priced to Compete with Generic Card Readers
7. AgriLife Research genetically fingerprinting E. coli from watersheds
8. Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures
9. Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures
10. DNA fingerprinting pioneer discovers role of key genetic catalyst for human diversity
11. Fingerprinting method reveals fate of mercury in Arctic snow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... USA New Geology articles posted ... 2013 cover a wide swath of geoscience subdisciplines, ... geophysics, and paleobotany. Locations studied include Siberia; the ... Alpi Apuane, Italy; Ukraine; Mars; and the Southeastern ... 1. Rubies, jadeite, and plate tectonics;, 2. The ...
(Date:5/19/2013)... strain of electricity-producing bacteria that can grow using hydrogen ... as its sole source of carbon. Researchers at ... the 113th General Meeting of the American Society for ... production solely on hydrogen," says Amit Kumar, a researcher ... part of the Lovley Lab Group at the university. ...
(Date:5/18/2013)... AGA Research Foundation is honored to announce the first ... Cancer, which will support Andrew D. Rhim, MD, from ... Pennsylvania, Philadelphia, as he furthers his research on the ... progression. , "The AGA Research Foundation is humbled to ... and AGA Legacy Society members," said Nicholas F. LaRusso, ...
Breaking Biology News(10 mins):New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 3New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 4New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 5New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 6New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 7New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 8New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 9New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 10New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 11AGA Research Foundation grant furthers digestive cancer research 2
... Policy Center is hosting a lecture and symposium Tuesday, ... better understand the disastrous floods of summer 2008. ... topic of this symposium in The Forkenbrock Series on ... the science of floods to the psychological impact of ...
... more than 30 million acres of agricultural land ... numbers have been increasing significantly since then. With ... seeking environmentally friendlier alternatives to conventional plastic mulch. ... higher yields, increased quality, improved disease and insect ...
... Otto, NC New research by U.S. Forest Service ... hemlock woolly adelgid is killing hemlock trees faster than ... carbon cycle of these forests. SRS researchers and cooperators ... the most recent issue of the journal Ecosystems ...
Cached Biology News:Public Policy Center hosts flood symposium March 10-12 2Biodegradable mulch films on the horizon 2Study finds hemlock trees dying rapidly, affecting forest carbon cycle 2
(Date:5/22/2013)... May 22, 2013 Mold remediation could take ... that there is a way to cut down the process' ... its latest post the details of a method how ... , Mold could be prevented, My Cleaning Products said. But ... stated that a mold remediation must then be promptly implemented ...
(Date:5/22/2013)... Envera announced today that Michael McErlean ... McErlean has an extensive background in cell production and ... career. , Mike Matheny, President and Owner ... Mike join our team”. “Mike’s background is perfectly suited ... and downstream processing equipment”, added Matheny. “Mike’s hands ...
(Date:5/22/2013)... 2013  Moderna Therapeutics, the pioneering company developing messenger ... the in vivo production of therapeutic proteins, ... will join Moderna in early July as its first ... proven leader in the design and implementation of information ... to translation, clinical operations and commercial preparedness. John has ...
(Date:5/21/2013)...  The Lindsley F. Kimball Research Institute of the New ... Grand Challenges Explorations winner, an initiative funded by the ... Sara Lustigman , Head of the Laboratory of Molecular ... project, titled Innovative 3-D in vitro culturing ... screen drugs to help eliminate onchocerciasis (river blindness) in ...
Breaking Biology Technology:How to Kill Mold While Saving Thousands of Dollars on Mold Remediation Projects Explained by My Cleaning Products 2Envera Appoints Michael McErlean Fermentation Manager 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3New York Blood Center's Research Institute Receives Grand Challenges Explorations Grant For Groundbreaking Research in Global Health and Development 2New York Blood Center's Research Institute Receives Grand Challenges Explorations Grant For Groundbreaking Research in Global Health and Development 3
... Life Sciences,Holdings, Inc. (Nasdaq: ADLS ) a biopharmaceutical ... drugs in the,therapeutic areas of infection, cancer and respiratory ... Leaders Bank to increase,its line of credit from $4 ... of,maturity by 12 months to January 1, 2011. The ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ), a clinical-stage ... novel medicines in the areas of,hepatitis C and ... the third quarter ended September 30, 2008., ... of our hepatitis C,development programs," said Steve Worland ...
... CALGARY, Oct. 23 /PRNewswire-FirstCall/ - Oncolytics Biotech ... an abstract entitled "A Phase I,Study to ... Docetaxel in Patients with Advanced Malignancies" will ... Journal of Immunotherapy, the official,journal of the ...
Cached Biology Technology:Advanced Life Sciences Completes Debt Transaction 2Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 2Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 3Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 4Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 5Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 6Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 7Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 8Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 3
... except that it uses a deep-UV deuterium bulb, ... comes with a shutter (controlled via a TTL ... Light Source produces a powerful, stable output from ... light source are available, providing a wavelength range ...
... and mitochondrial membrane potential. The mitochondrial permeability ... the initiation of cellular apoptosis. This process ... the electrochemical gradient across the mitochondrial membrane, ... membrane potential (YD). Loss of mitochondrial YD ...
... The NOVOstar is an exciting product ... Previously, cell-based assays required the use of ... accessibility for scientists in the assay development ... necessary for cell-based assays as well as ...
... Clamp One can operate as a Voltage Clamp, ... (Dynamic) Clamp in electrophysiology research applications. Performance in ... analog equipment. • This ... advances in the capabilities of Digital Signal Processing ...
Biology Products: