Navigation Links
lobSTR algorithm rolls DNA fingerprinting into 21st century
Date:4/27/2012

CAMBRIDGE, Mass. (April 27, 2012) As any crime show buff can tell you, DNA evidence identifies a victim's remains, fingers the guilty, and sets the innocent free. But in reality, the processing of forensic DNA evidence takes much longer than a 60-minute primetime slot.

To create a victim or perpetrator's DNA profile, the U.S. Federal Bureau of Investigation (FBI) scans a DNA sample for at least 13 short tandem repeats (STRs). STRs are collections of repeated two to six nucleotide-long sequences, such as CTGCTGCTG, which are scattered around the genome. Because the number of repeats in STRs can mutate quickly, each person's set of these genetic markers is different from every other person's, making STRs ideal for creating a unique DNA fingerprint.

The FBI first introduced their STR identification system in 1998, when STRs were the darling of the genetics community. However, other identifying genomic markers were soon discovered and gained in popularity. Around the same time, high throughput sequencing allowed researchers to process vast amounts of DNA, but using methods that were ineffectual in repeated DNA, including STRs. STRs were mostly forgotten by geneticists, and innovations to study them stalled.

Now Whitehead Institute researchers have pulled STR identification into the 21st Century by creating lobSTR, a three-step system that accurately and simultaneously profiles more than100,000 STRs from a human genome sequence in one daya feat that previous systems could never complete. The lobSTR algorithm is described in the May issue of Genome Research.

"lobSTR found that in one human genome, 55% of the STRs are polymorphic, they showed some difference, which is very surprising," says Whitehead Fellow Yaniv Erlich. "Usually DNA's polymorphism rate is very low because most DNA is identical between two people. With this tool, we provide access to tens of thousands of quickly changing markers that you couldn't get
'/>"/>

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers develop optimal algorithm for determining focus error in eyes and cameras
2. UT researchers develop algorithm to improve remote electrocardiography
3. MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence
4. MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence
5. Scientists use computer algorithms to develop seasonal flu vaccines
6. Hoyos Corporation Rolls Out First Iris-Biometrics System Priced to Compete with Generic Card Readers
7. AgriLife Research genetically fingerprinting E. coli from watersheds
8. Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures
9. Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures
10. DNA fingerprinting pioneer discovers role of key genetic catalyst for human diversity
11. Fingerprinting method reveals fate of mercury in Arctic snow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... June 24, 2015 Biometry authentication provider ... biometric password solution one face in. ... one face in, entering the expanding biometric ... affordable multifactor-authentication biometric answer to the password problem. ... in partnership with KeyLemon, one face in allows ...
(Date:6/23/2015)... 22, 2015 Research ... of the "Body-Worn Temperature Sensors Market - ... Forecast 2014 - 2020" report to their ... of the global body-worn temperature sensors market. The ... on the basis of types, care setting, patient ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... vaginal infection linked to preterm birth appears to escalate ... University of Pittsburgh School of Medicine study presented today ... Society for Obstetrics and Gynecology in Boston. When ... preterm birth goes up, said Hyagriv Simhan, M.D., M.S.C.R., ...
... hair cells dominates the process of sound amplification in ... those cells dominates the response in non-mammals , A ... inner ear amplify sound in mammals appears to have ... rather than vibrating, hair-like cilia, according to investigators at ...
... on Emerging Nanotechnologies Director David Rejeski, “Today, FDA took ... oversight. If nanotechnology regulation was a baseball game, FDA ... But the agency must act rapidly to adopt and ... quickly and building on the recommendations in the Task ...
Cached Biology News:Risk of common vaginal infection linked to preterm birth appears higher for blacks 2St. Jude study solves mystery of mammalian ears 2St. Jude study solves mystery of mammalian ears 3FDA sees nanotech challenges in every product category it regulates 2
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making is a madatory ... distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter that lets metrologists ... NIR range. Previous spectrophotometer calibration standards, such as those made from didymium glass were ...
(Date:6/29/2015)...  AACC, a global scientific and medical professional ... is pleased to announce that the impact factor ... increased to 7.9 in the 2014 Thomson Reuters ... Chemistry in the top 3% of all ... the research it publishes on laboratory medicine and ...
(Date:6/29/2015)... , June 29, 2015   Veracyte, Inc . ... the field of molecular cytology, today announced that it ... prestigious Top Workplaces list for the second year in ... based solely on an annual survey of Bay Area-company ... that the degree to which Veracyte values our employees ...
(Date:6/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... listed in the management information circular dated June 1, ... Meeting of Shareholders, held earlier today, June 26 ... 5 nominees proposed by management were elected as ... Company,s next Annual Meeting of Shareholders or until ...
Breaking Biology Technology:FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3
... Mass. and TORONTO, Dec. 1, 2011 Generex Biotechnology ... update on the status of the clinical and ... buccal insulin spray product. Work has ... new analyses), and revising all of the extant ...
... of two leading cell image resource centers now provides ... and analyzing microscope images in great detail. The American ... for Microscopy and Imaging Research (NCMIR) at the University ... provide a unified interface. This union extends ASCB,s The ...
... displays in the mid-1960s, display electronics have undergone ... have shown several advantages over LCDs, including their ... high power efficiency and quick response. ... phones, digital cameras and other portable devices. But ...
Cached Biology Technology:Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 2Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 3Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 4Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public 2Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public 3UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays 2
... Blood bank refrigerators: ,Each upright ... and superior 4C temperature uniformity for refrigerated ... HemaPro 2000 Surveillance Module for complete blood ... BBR37 are equipped with the HemaPro 101 ...
Sterile, individually wrapped, 4mm Cuvettes...
... an enhanced form of Tobacco Etch Virus ... active, and significantly more stable than native ... Protease specifically recognizes a seven amino acid ... it useful for removing affinity tags from ...
... The LCMS-2010EV is a fully flexible quadrupole ... conventional HPLC, high-speed HPLC, 1-D and 2-D ... scale separations. It incorporates a drying gas ... for high sensitivity, especially for low-to-medium polarity ...
Biology Products: