Navigation Links
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
Date:7/28/2009

xactly where DLX5 protein binds to the promoter region of the MYC gene. They found that there were two sites where DLX5 could bind to the MYC promoter, which is a section of DNA where certain proteins known as transcription factors attach in order to recruit the cellular machinery used to transcribe genes into messenger RNA and then proteins. Studies in both cells and a mouse model for cancer showed that they could promote the expression of MYC by transfecting cells with DNA strands containing DLX5.

Too much DLX5, they found, led to too much MYC. When they knocked out expression of DLX5 in lung cancer cells, it resulted in decreased expression of MYC and reduced cell proliferation. By adding an overabundance of MYC, they found they could turn those cells cancerous again.

From this, Testa and Xu were able to gain a broader understanding of how cancers involving AKT2, DLX5 and MYC might develop. A mutation in AKT2 may act as a "first hit" that makes the inversion on mouse chromosome 6, which contains the DLX5 gene, more likely. When the inversion happens, the cell begins producing the DLX5 protein, a multipurpose transcription factor that normally has a very limited role in adult cells. One of the targets of DLX5 is the MYC gene itself, causing the cells to produce many copies of the MYC oncoprotein.

Normally MYC regulates many functions within the cell, including cell division. With an overabundance of MYC, the cell may reproduce out of control, accumulating in each generation the further genetic damage that is the hallmark of cancer cells.


'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
2. U.S. Army and Navy Purchase Over 10,000 New Beretta M9 Pistols
3. McPherson County Kansas to Purchase Stingers
4. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
5. Canyon County Idaho Sheriffs Office to Purchase Stinger S-200s
6. bioMETRX, Inc. Completes Sequiam Asset Purchase
7. 1-hit event provides new opportunity for colon cancer prevention, say Fox Chase researchers
8. Dogs chase efficiently, but cats skulk counterintuitively
9. G. Unger Vetlesen Foundation funds purchase of state-of-the-art equipment for UMs Rosenstiel School
10. Researchers identify proteins involved in new neurodegenerative syndrome
11. Texas researchers and educators head for Antarctica
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... have succeeded in treating cerebral palsy with autologous cord ... a 2.5 year old boy had been in a ... Just two months after treatment with the cord blood ... following months, the child learned to speak simple sentences ... a Korean study, dispel the long-held doubts about the ...
(Date:5/23/2013)... world,s largest and fastest growing open-access publishers, announces ... in Bioengineering and Biotechnology . , A ... in Bioengineering and Biotechnology will provide a ... and biotechnology research to be disseminated and discussed. ... will provide an open-science and interactive web ...
(Date:5/23/2013)... Wis. In an age when microbial pathogens are ... tamp down infection, a team of Wisconsin scientists has ... curbing the bacteria that cause staph infections. , Writing ... Society , a group led by University of Wisconsin-Madison ... with the "quorum sensing" behavior of Staphylococcus aureus ...
Breaking Biology News(10 mins):First successful treatment of pediatric cerebral palsy with autologous cord blood 2Frontiers launches new open-access journal in Bioengineering and Biotechnology 2University of Wisconsin chemists find new compounds to curb staph infection 2
... University of Houston Green Building Components (UHGBC), a program ... its third annual UHGBC Expo. This event showcases the ... commercialize green building components and sustainable technologies for the ... p.m., Nov. 17 in the College of Architecture,s atrium. ...
... New research identifies the brain chemicals and ... and anxiety, giving potential new directions to their ... early-life depression and anxiety changes the structure of ... Neuroscience 2011, the Society for Neuroscience,s annual meeting ...
... carry a particular variant of a gene run an ... finding from the interdisciplinary research at the Department of ... Gothenburg, Sweden. Researchers in the longitudinal project Gteborg ... D2 receptor gene and found that a variant of ...
Cached Biology News:UH Green Building Components Expo showcasing eco-friendly projects 2Mental illness: Probing the causes of schizophrenia, depression and anxiety 2
(Date:5/23/2013)... , May 23, 2013 BioTrends Research ... advisory firms for specialized biopharmaceutical issues, finds that, ... infectious disease specialists reported that in the past ... intentionally delaying treatment) in anticipation of the next ... months ago, when only 6 percent reported that ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 The New ... STEM industries, Black Data Processing Associates (BDPA), is hosting ... June 8, 2013. This all-day event will encourage students ... learn the ins and outs from many of the ... p.m. at the New Jersey Institute of Technology, the ...
(Date:5/23/2013)... , May 23, 2013 Pusan ... Inc., a private biotherapeutics and contract research company ... products for cancer, announced today a publication reporting ... treated with the oncolytic and immunotherapeutic vaccinia JX-594 ... research was published in the May 15 th ...
(Date:5/23/2013)... Bed bugs compromised Penn State. A report ... Meanwhile, My Cleaning Products offered complimentary samples of its bed ... without using harmful chemical elements. , Based on the ... building was actually a dormitory , My Cleaning Products ... May 13 and bed bug presence was confirmed on May ...
Breaking Biology Technology:The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... Option, Says DuPont Leader at UN Food and ... Agriculture Conference, ROME, ... grain farmers harvest from their land and help address the,strong and growing ... ) business Pioneer Hi-Bred, told a United Nations Food and,Agriculture Organization Conference ...
... nation,s,largest surrogacy agency, has launched a new program that ... and allows them to use,their own sperm to create ... due to advances in technology that can,test semen for ... California,legislation enacted in January that provides the opportunity to ...
... Offer Design Flexibility and Transmission and ... Induction Functionality --, Medical Design & Manufacturing East DRC,s ... ... June 3 Dynamics Research,Corporation,s Metrigraphics Division (Nasdaq: DRCO ), a world-leading,precision ...
Cached Biology Technology:More Can Be Done Now to Address the Growing Global Demand for Grain 2More Can Be Done Now to Address the Growing Global Demand for Grain 3Growing Generations Announces Surrogacy Program for Men with HIV 2DRC's Metrigraphics Announces Family of Micro-Induction Coils for Implanted and Traditional Medical Applications 2DRC's Metrigraphics Announces Family of Micro-Induction Coils for Implanted and Traditional Medical Applications 3DRC's Metrigraphics Announces Family of Micro-Induction Coils for Implanted and Traditional Medical Applications 4
... Pyrophosphate Detection Kit,provides a fast, convenient ... inorganic pyrophosphate (PPi ) produced,by a ... DNA and,RNA polymerizations, cyclic AMP formation ... enzymatic activation of fatty acids to,form ...
... contains a unique β-agarose digesting enzyme developed ... intact DNA and RNA from low melting ... TAE, TBE, MOPS, or phosphate buffers. The ... TAE, TBE, MOPS, and phosphate electrophoresis buffers ...
Request Info...
... The new Thermo Electron RapidStak provides valuable ... Utilizing a unique buffer nest technology for ... the RapidStak provides fast, reliable automation for ... and walk-away confidence. The RapidStak can be ...
Biology Products: