Navigation Links
deCODE discovers cause of major subtype of glaucoma
Date:8/13/2007

Reykjavik, Iceland, August 9, 2007 In a paper published today in the journal Science, scientists from deCODE genetics (Nasdaq:DCGN) and academic colleagues from the National University Hospital in Reykjavik and Uppsala University in Sweden report the discovery of two common single letter variations (SNPs) in the sequence of the human genome that appear to account for virtually all cases of a major subtype of glaucoma. The SNPs are located in the LOXL1 gene on chromosome 15, and confer respectively 26-fold and 8-fold increases in risk of exfoliation glaucoma compared to the low-risk versions of the same markers. Approximately 25% of those in the Icelandic and Swedish study cohorts were found to have two copies of the highest risk variant, putting them at approximately 100 times the likelihood of developing exfoliation glaucoma (XFG) as are individuals with the low risk version of the same SNP. The LOXL1 protein encoded by the gene is involved in the formation of elastin fibers which, when they accumulate in the eye, cause XFG.

The paper, entitled Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma, is published today in the online edition of Science, and will appear in an upcoming print edition of the journal.

This discovery is remarkable and important because the genetics has led us directly to what appears to be the sole cause of a devastating common disease. The risk conferred by these variants is such that it accounts for virtually all cases of exfoliation glaucoma, meaning that if we can neutralize the impact of these variants we might eliminate the disease. The LOXL1 protein made by this gene appears to play a role in the accumulation of microfibullar deposits that causes XFG, providing a promising mechanism to target for developing therapy. We plan to conduct additional studies to examine how we can take advantage of this finding to begin drug discovery, said Kari Stefansson, CEO of deCODE.


'/>"/>
Contact: Berglind R. Olafsdottir
bro@decode.com
354-664-2393
deCODE genetics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers show how brain decodes complex smells
2. Plant protection from cold decoded
3. UCSD team discovers specialized, rare heart stem cells in newborns
4. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
5. Biologist Discovers What May Be World’s ‘Pickiest?Mates
6. MIT chemist discovers secret behind natures medicines
7. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
8. Expedition discovers marine treasures
9. Team discovers possible universal strategy to combat addiction
10. Nobelist discovers antidepressant protein in mouse brain
11. Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/6/2014)... from a team of Florida State University biologists could ... adapt to and survive environmental swings such as droughts ... issue of the journal The Plant Cell , ... and proteins) is organized in a cell and how ... turned on and others are turned off. , "If ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2
... Novel use of genetic testing methods helped public health ... outbreaks of foodborne hepatitis A virus in 2003 related ... detailed analysis published in the October 15 issue of ... The authors of the study, Joseph J. Amon, PhD, ...
... methods helped public health officials control and limit the ... virus in 2003 related to the consumption of green ... October 15 issue of The Journal of Infectious Diseases, ... Joseph J. Amon, PhD, MSPH, and colleagues at the ...
... drug of choice for long-distance truckers and college students ... fruit flies, too. This finding is one of several ... for the neurotransmitter dopamine in the modulation of sleep, ... by Dr. Ralph Greenspan and colleagues at The Neurosciences ...
Cached Biology News:Disrupting Cocaine-memories To Battle Addiction 2Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance 2
(Date:11/24/2014)... DUBAI , UAE, November 24, 2014 ... prestigious "Sheikh Hamdan Bin Rashid Al Maktoum Awards for ... in Dubai, United Arab Emirates , ... http://photos.prnewswire.com/prnh/20141124/717861 ) , The Carter Center ... Medical Services is actively involved in numerous programs that ...
(Date:11/24/2014)... NAMUR , Belgium , Nov. 24, ... life sciences company focused on developing diagnostic tests for cancer ... lung cancer study will be presented at the Science for ... Louvain-la-Neuve, Belgium . The data come from ... collected at the Pneumology department of the Centre Hospitalier Universitaire ...
(Date:11/24/2014)... Calif. , Nov. 24, 2014   Veracyte, Inc. ... Bonnie H. Anderson , president and chief executive officer, will ... 26 th Annual Healthcare Conference on Tuesday, December 2, ... . The live audio webcast and subsequent ... http://investor.veracyte.com . Please connect to the website at least 15 ...
(Date:11/24/2014)... MD (PRWEB) November 24, 2014 ... underrepresented patient populations into clinical trials at its ... , “Continental was created with the idea ... play a fundamental role in medical advances," said ... Tuskegee syphilis experiment to the immortal cell line ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... BIO attendees , , Editors note : ... current Secretary of Health and Human Services Tommy Thompson, ... BIO 2004 Conference, talking place this week in San ... mayor, Gavin Newsom, pitched the crowd to not forget ...
... take to make a payroll and personnel tracker specifically for ... taken its tracking systems, originally generic, and made them into ... in Georgia. WellStar plans to use the application to manage ... unusual challenges. , ,"Our initial HR system was not health ...
... has introduced two new AV-ready Mediasite products designed ... variety of uses. The new products, evolved from ... intended to enable customers to record and distribute ... education, online training, product marketing and other related ...
Cached Biology Technology:WTN Interview: HHS Secretary calls for $550 million health care fund to reduce deaths caused by medical errors 2WTN Interview: HHS Secretary calls for $550 million health care fund to reduce deaths caused by medical errors 3Sonic Foundry announces new Mediasite products 2
Porcine TNF-alpha/TNFSF1A ELISpot Development Module...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
... Attoglow Western Blot Analysis Kit ... analysis kit developed by Biochain. It ... g) or yoctomole (10 -24 ... of three parts: Millennium Enhancer, protein ...
... BioNumerics is the universal bioinformatics software that ... data. The unique modular design of BioNumerics ... virtually any type of data employed for ... microarrays, DNA fingerprints, 2-D protein gels, HPLC, ...
Biology Products: