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A key enzyme helps keep the synapse on track
Date:12/21/2007

ynj1 to the "knockout" neurons restored healthy endocytosis and cell-to-cell synaptic communication, the researchers found.

"The importance of synj1 to endocyotosis generally came as a surprise," Dr. Ryan says. "This expands yet again our knowledge of this crucial neuronal machinery and gives us new targets for research into the origins of neurological diseases and potential ways to treat them."

He stressed that the cure for brain diseases is not imminent based on these types of findings, but the building blocks are being added, one by one.

"In the future, medicine will be highly personalized, based on an intimate knowledge of key mutations each of us may carry that predispose us to neurological disease," Dr. Ryan explains. "All of that will come to pass over the next few decades. But this is 2007, and right now we're still busy writing the 'shop manual' for how the brain is made and works. Discoveries like these are adding new pages to the manual every day, and it's that kind of knowledge that will someday save and enhance lives."


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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