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Zooming in on genetic shuffling
Date:7/10/2008

says Steinmetz.

The map revealed many new insights into the organisation of recombination in yeast. On average over 150 recombination events were observed during a typical meiosis. These events did not occur uniformly across the genome. The recombination rate varied according to location, with events concentrated at so-called hotspots, some of which favoured either crossovers or non-crossovers. The researchers also found evidence for interference between crossovers and non-crossovers - a phenomenon previously only known to occur between crossovers - that makes it unlikely for two recombination events to happen in close proximity.

The fundamental principles of recombination are likely to be shared between yeast and humans. "Our map expands our understanding of crossover and provides a wealth of new information about non-crossovers and gene conversion. It will act as a reference for future research into recombination," says Richard Bourgon from Huber's group, who developed the statistical methodology for this new type of data.

The insights gained will not only help tackle questions about the basic mechanisms of recombination; they will also have practical implications for the tracking of disease genes in humans.


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Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

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